Gene/Proteome Database (LMPD)

LMPD ID
LMP011842
Gene ID
445176
Species
Danio rerio (Zebrafish)
Gene Name
major facilitator superfamily domain containing 2ab
Gene Symbol
mfsd2ab
Synonyms
mfsd2; NLS1-B; mfsd2b; zgc:101069
Alternate Names
sodium-dependent lysophosphatidylcholine symporter 1-B; sodium-dependent LPC symporter 1-B; major facilitator superfamily domain containing 2; major facilitator superfamily domain containing 2b; major facilitator superfamily domain-containing protein 2A-B
Chromosome
19

Proteins

sodium-dependent lysophosphatidylcholine symporter 1-B
Refseq ID NP_001003570
Protein GI 57525841
UniProt ID Q6DEJ6
mRNA ID NM_001003570
Length 523
RefSeq Status PROVISIONAL
MAKGEGAEQYTNTSLLQKPSPDEVKLAKHETKSRLSVCSKLCYAIGGAPYQITGCAIGFFLQIYLLDVALLDPFYASIILFVGRAWDAVTDPTVGFLVSRTPWTRFGRMMPWIVLSTPFAVLCYFLIWYVPSVDQGKVVWYLIFYCCFQTLQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTLIGTAIQGQIVGMANAPCISTEIDLNSTGLEVAPDVNITDPHVSLQDLRNAYMIASGVICAIYVVCAVVLFLGVKEQKDTCRVRTEPMSFFQGICMVMGHGPYAKLVMGFLFTSLAFMLLEGNFALFCIYNLGFRNDFQNVLLVIMLSATLAIPFWQWFLTKFGKKTAVYIGTTSVVPFLISVVLVPSSLAVTYIASFAAGVSVAAAFLLPWSMLPDVVDDFKVQNPESQGHEAIFYSFYVFFTKFASGVSLGVSTLSLDFAGYVTRGCTQPGEVKLTLKILVSAAPIVLIIIGLLIFISYPINEEKRQGNRKLLNEQRENEMDSETDSTELNVV

Gene Information

Entrez Gene ID
445176
Gene Name
major facilitator superfamily domain containing 2ab
Gene Symbol
mfsd2ab
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005887 ISS:UniProtKB C integral component of plasma membrane
GO:0005548 ISS:UniProtKB F phospholipid transporter activity
GO:0015293 ISS:UniProtKB F symporter activity
GO:0060856 ISS:UniProtKB P establishment of blood-brain barrier
GO:0015908 ISS:UniProtKB P fatty acid transport
GO:1990379 ISS:UniProtKB P lipid transport across blood brain barrier
GO:0015914 ISS:GOC P phospholipid transport
GO:0045056 ISS:UniProtKB P transcytosis
GO:0055085 ISS:GOC P transmembrane transport

Domain Information

InterPro Annotations

Accession Description
IPR016196 MFS_dom_general_subst_transpt

UniProt Annotations

Entry Information

Gene Name
major facilitator superfamily domain containing 2ab
Protein Entry
NLS1B_DANRE
UniProt ID
Q6DEJ6
Species
Zebrafish

Comments

Comment Type Description
Function Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega- 3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). {ECO:0000250}.
Similarity Belongs to the major facilitator superfamily. {ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011842 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
57525841 RefSeq NP_001003570 523 sodium-dependent lysophosphatidylcholine symporter 1-B

Identical Sequences to LMP011842 proteins

Reference Database Accession Length Protein Name
GI:57525841 GenBank AAH77117.1 523 Major facilitator superfamily domain containing 2b [Danio rerio]
GI:57525841 SwissProt Q6DEJ6.1 523 RecName: Full=Sodium-dependent lysophosphatidylcholine symporter 1-B; Short=NLS1-B; Short=Sodium-dependent LPC symporter 1-B; AltName: Full=Major facilitator superfamily domain-containing protein 2A-B [Danio rerio]

Related Sequences to LMP011842 proteins

Reference Database Accession Length Protein Name
GI:57525841 GenBank AHH37699.1 525 Major facilitator superfamily domain-containing protein 2A-B [Ictalurus punctatus]
GI:57525841 RefSeq XP_003458535.1 527 PREDICTED: major facilitator superfamily domain-containing protein 2A-B-like [Oreochromis niloticus]
GI:57525841 RefSeq XP_005728947.1 527 PREDICTED: major facilitator superfamily domain-containing protein 2A-B-like [Pundamilia nyererei]
GI:57525841 RefSeq XP_005940938.1 527 PREDICTED: major facilitator superfamily domain-containing protein 2A-B-like [Haplochromis burtoni]
GI:57525841 RefSeq XP_006795265.1 527 PREDICTED: major facilitator superfamily domain-containing protein 2A-B-like [Neolamprologus brichardi]
GI:57525841 RefSeq XP_008285841.1 523 PREDICTED: major facilitator superfamily domain-containing protein 2A [Stegastes partitus]