Gene/Proteome Database (LMPD)

LMPD ID
LMP011808
Gene ID
436617
Species
Danio rerio (Zebrafish)
Gene Name
retinoid X receptor, gamma b
Gene Symbol
rxrgb
Synonyms
zgc:92183
Chromosome
20

Proteins

retinoic acid receptor RXR-gamma-B
Refseq ID NP_001002345
Protein GI 50539758
UniProt ID Q6DHP9
mRNA ID NM_001002345
Length 452
RefSeq Status PROVISIONAL
MDTHDTYLHLHSSPLNSSPSQPPVMSSMVGHPSVISSSRPLPSPMSTLGSSMNGLPSPYSVITPSLSSPSISLPSTPSMGFNTLNSPQMNSLSMNGNEDIKPPPGLAPLGNMSSYQCTSPGSLSKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYTCRDIKECLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKEKSDTEVETTSRFNEDMPVDKILDAELSVEPKTETYTESSPSNSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLPLDDQVILLRAGWNELLIASFSHRSITVKDGILLGTGLHVHRSSAHSAGVGSIFNRVLTELVSKMKDMQMDKTELGCLRAIVLFNPDAKGLSNSLEVEALREKVYASLETYTKQKYPDQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQIT

Gene Information

Entrez Gene ID
436617
Gene Name
retinoid X receptor, gamma b
Gene Symbol
rxrgb
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003700 IEA:InterPro F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR021780 Nuclear/hormone receptor activator site AF-1
IPR000003 Retinoid X receptor/HNF4
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
retinoid X receptor, gamma b
Protein Entry
Q6DHP9_DANRE
UniProt ID
Q6DHP9
Species
Zebrafish

Comments

Comment Type Description
Developmental Stage Expressed zygotically.
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid (By similarity).
Similarity Belongs to the nuclear hormone receptor family. NR2 subfamily.
Similarity Contains 1 nuclear receptor DNA-binding domain.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Subunit Homodimer. Heterodimer; with a rar molecule. Binds DNA preferentially as a rar/rxr heterodimer.
Tissue Specificity By the 5-somite stage, expressed in the anterior spinal cord. Expression becomes restricted to the ventral spinal cord and by 24 hpf, expression is low and restricted to the medial ventral spinal cord.

Identical and Related Proteins

Unique RefSeq proteins for LMP011808 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
50539758 RefSeq NP_001002345 452 retinoic acid receptor RXR-gamma-B

Identical Sequences to LMP011808 proteins

Reference Database Accession Length Protein Name
GI:50539758 GenBank AAH75918.1 452 Zgc:92183 [Danio rerio]
GI:50539758 GenBank ABM89230.1 452 retinoid X receptor gamma b [Danio rerio]
GI:50539758 SwissProt Q6DHP9.1 452 RecName: Full=Retinoic acid receptor RXR-gamma-B; AltName: Full=Nuclear receptor subfamily 2 group B member 3-B; AltName: Full=Retinoid X receptor gamma-B [Danio rerio]

Related Sequences to LMP011808 proteins

Reference Database Accession Length Protein Name
GI:50539758 GenBank ADK77881.1 453 retinoid X receptor gamma [Sparus aurata]
GI:50539758 GenBank AFV31633.1 453 retinoic X receptor gamma, partial [Acanthopagrus schlegelii]
GI:50539758 RefSeq XP_005160723.1 465 PREDICTED: retinoic acid receptor RXR-gamma-B isoform X1 [Danio rerio]
GI:50539758 RefSeq XP_007245492.1 460 PREDICTED: retinoic acid receptor RXR-gamma-B-like isoform X1 [Astyanax mexicanus]
GI:50539758 RefSeq XP_007245493.1 454 PREDICTED: retinoic acid receptor RXR-gamma-B-like isoform X2 [Astyanax mexicanus]
GI:50539758 RefSeq XP_007558779.1 453 PREDICTED: retinoic acid receptor RXR-gamma-B isoform X2 [Poecilia formosa]