Gene/Proteome Database (LMPD)

LMPD ID
LMP011773
Gene ID
406667
Species
Danio rerio (Zebrafish)
Gene Name
phosphatidylinositol 4-kinase type 2 alpha
Gene Symbol
pi4k2a
Synonyms
pi4kii; zgc:63646; wu:fc84f05; pi4kII alpha
Alternate Names
phosphatidylinositol 4-kinase type 2-alpha; PI4KII-alpha; phosphatidylinositol 4-kinase type II; phosphatidylinositol 4-kinase II alpha; phosphatidylinositol 4-kinase type II-alpha
Chromosome
1
EC Number
2.7.1.67

Proteins

phosphatidylinositol 4-kinase type 2-alpha
Refseq ID NP_998523
Protein GI 47087019
UniProt ID Q6PE18
mRNA ID NM_213358
Length 447
RefSeq Status PROVISIONAL
MDETSPLVSPLRDSNDFNYGPAEPTSPRGGFGSTPGSVVRLPAGSPGRSRERQPLLDRDRGASPRDPHRNEFPEDPEFREIIRKAERAIEEGIYPERIYQGSSGSYFVKDSAGKIIGVFKPKNEEPYGQLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFHRIGLPPKVGSFQIFVEGYKDADFWLRRFEAEPLPENTNRQLQLQFERLVVLDYIIRNTDRGNDNWLIKYDYPMDTSSNRDSDWVLVKDPIIKLAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVVFSQEIRDLVLPKLADPNFIKDLEEDLYELFKKDPGFDRGQFKKQVSVMRGQILNLSQAMRDGKTPLQLVQMPPVIVETARVPQRANSESYTQSFQSRRPFFTWW

Gene Information

Entrez Gene ID
406667
Gene Name
phosphatidylinositol 4-kinase type 2 alpha
Gene Symbol
pi4k2a
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0030054 IEA:UniProtKB-KW C cell junction
GO:0031410 ISS:UniProtKB C cytoplasmic vesicle
GO:0030425 ISS:UniProtKB C dendrite
GO:0005768 ISS:UniProtKB C endosome
GO:0035838 ISS:UniProtKB C growing cell tip
GO:0044231 ISS:UniProtKB C host cell presynaptic membrane
GO:0005739 ISS:UniProtKB C mitochondrion
GO:0043005 ISS:UniProtKB C neuron projection
GO:0043025 ISS:UniProtKB C neuronal cell body
GO:0042734 ISS:UniProtKB C presynaptic membrane
GO:0004430 IEA:UniProtKB-EC F 1-phosphatidylinositol 4-kinase activity
GO:0035651 ISS:UniProtKB F AP-3 adaptor complex binding
GO:0005524 IEA:UniProtKB-KW F ATP binding

KEGG Pathway Links

KEGG Pathway ID Description
dre00562 Inositol phosphate metabolism
dre_M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4

REACTOME Pathway Links

REACTOME Pathway ID Description
6176823 Synthesis of PIPs at the early endosome membrane
6176819 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 4-kinase type 2 alpha
Protein Entry
P4K2A_DANRE
UniProt ID
Q6PE18
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.
Function Contributes to the overall PI4-kinase activity of the cell. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3) (By similarity). {ECO:0000250}.
Similarity Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. {ECO:0000305}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Membrane raft {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Mitochondrion {ECO:0000250}. Endosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011773 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
47087019 RefSeq NP_998523 447 phosphatidylinositol 4-kinase type 2-alpha

Identical Sequences to LMP011773 proteins

Reference Database Accession Length Protein Name
GI:47087019 GenBank AAH58342.1 447 Phosphatidylinositol 4-kinase type 2 alpha [Danio rerio]
GI:47087019 GenBank AAY16565.1 447 phosphatidylinositol 4-kinase II alpha [Danio rerio]
GI:47087019 SwissProt Q6PE18.1 447 RecName: Full=Phosphatidylinositol 4-kinase type 2-alpha; AltName: Full=Phosphatidylinositol 4-kinase type II-alpha [Danio rerio]

Related Sequences to LMP011773 proteins

Reference Database Accession Length Protein Name
GI:47087019 RefSeq XP_003455875.1 447 PREDICTED: phosphatidylinositol 4-kinase type 2-alpha-like [Oreochromis niloticus]
GI:47087019 RefSeq XP_003972073.1 447 PREDICTED: phosphatidylinositol 4-kinase type 2-alpha-like [Takifugu rubripes]
GI:47087019 RefSeq XP_004539108.1 447 PREDICTED: phosphatidylinositol 4-kinase type 2-alpha-like [Maylandia zebra]
GI:47087019 RefSeq XP_005735724.1 447 PREDICTED: phosphatidylinositol 4-kinase type 2-alpha-like [Pundamilia nyererei]
GI:47087019 RefSeq XP_005925189.1 447 PREDICTED: phosphatidylinositol 4-kinase type 2-alpha-like [Haplochromis burtoni]
GI:47087019 RefSeq XP_008294475.1 447 PREDICTED: phosphatidylinositol 4-kinase type 2-alpha [Stegastes partitus]