Gene/Proteome Database (LMPD)

LMPD ID
LMP011764
Gene ID
406554
Species
Danio rerio (Zebrafish)
Gene Name
lysocardiolipin acyltransferase
Gene Symbol
lycat
Synonyms
lclat1; zgc:77380; wu:fj17g04
Alternate Names
lysocardiolipin acyltransferase 1
Chromosome
13
EC Number
2.3.1.-

Proteins

lysocardiolipin acyltransferase 1
Refseq ID NP_998435
Protein GI 47086103
UniProt ID Q6NYV8
mRNA ID NM_213270
Length 388
RefSeq Status PROVISIONAL
MVSPRGVCFLLFLLLGSVFGSVFMLGPLLPLMLLSPSRYRWITDRIVATWLTLPVALLELVLGVKVVVTGDGFIPGERSVIIMNHRTRLDWMFLWCCLLRYSYLRQEKICLKAALKSVPGFGWAMQVASFIFIQRRWEDDRTHMSNMLQYFCRIREPVQLLLFPEGTDLTENTRARSDEFAEKNGLQKYEYVLHPRTTGFTFIVDTLRGGDNLDAVHDITVAYPQNIPQTERHLLAGVFPREIHFHVQRFTVASVPAGAAGLQAWCQERWREKERRLQRFYETVPRRFDAPAVGVCVREPCCQSGQCVCVPRCKSEGRVRIILVASLLYWSVFITAACASLCLCPPAQFYFLFMVVFFLCQQRFTGGLELMELACHRYWSRRSADKQE

Gene Information

Entrez Gene ID
406554
Gene Name
lysocardiolipin acyltransferase
Gene Symbol
lycat
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0003841 IEA:UniProtKB-EC F 1-acylglycerol-3-phosphate O-acyltransferase activity
GO:0016024 IEA:UniProtKB-UniPathway P CDP-diacylglycerol biosynthetic process
GO:0035162 IDA:ZFIN P embryonic hemopoiesis
GO:0001885 IMP:ZFIN P endothelial cell development
GO:0060217 IMP:ZFIN P hemangioblast cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
dre00561 Glycerolipid metabolism
dre00564 Glycerophospholipid metabolism
dre01100 Metabolic pathways
dre_M00089 Triacylglycerol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
lysocardiolipin acyltransferase
Protein Entry
LCLT1_DANRE
UniProt ID
Q6NYV8
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate.
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. {ECO:0000250}.
Function Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Required for establishment of the hematopoietic and endothelial lineages. {ECO:0000250, ECO:0000269|PubMed:18388326}.
Pathway Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
Similarity Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011764 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
47086103 RefSeq NP_998435 388 lysocardiolipin acyltransferase 1

Identical Sequences to LMP011764 proteins

Reference Database Accession Length Protein Name
GI:47086103 GenBank AAH66444.1 388 Lysocardiolipin acyltransferase [Danio rerio]
GI:47086103 RefSeq XP_009305898.1 388 PREDICTED: lysocardiolipin acyltransferase 1 isoform X1 [Danio rerio]
GI:47086103 SwissProt Q6NYV8.1 388 RecName: Full=Lysocardiolipin acyltransferase 1 [Danio rerio]

Related Sequences to LMP011764 proteins

Reference Database Accession Length Protein Name
GI:47086103 EMBL CDQ56087.1 429 unnamed protein product [Oncorhynchus mykiss]
GI:47086103 RefSeq XP_003962800.1 397 PREDICTED: lysocardiolipin acyltransferase 1-like [Takifugu rubripes]
GI:47086103 RefSeq XP_006798490.1 385 PREDICTED: lysocardiolipin acyltransferase 1-like isoform X1 [Neolamprologus brichardi]
GI:47086103 RefSeq XP_006798491.1 385 PREDICTED: lysocardiolipin acyltransferase 1-like isoform X2 [Neolamprologus brichardi]
GI:47086103 RefSeq XP_007229059.1 387 PREDICTED: lysocardiolipin acyltransferase 1 [Astyanax mexicanus]
GI:47086103 RefSeq XP_008275124.1 385 PREDICTED: lysocardiolipin acyltransferase 1 [Stegastes partitus]