Gene/Proteome Database (LMPD)

LMPD ID
LMP011689
Gene ID
393896
Species
Danio rerio (Zebrafish)
Gene Name
dynamin 1-like
Gene Symbol
dnm1l
Synonyms
zgc:66163
Alternate Names
dynamin-1-like protein
Chromosome
25
EC Number
3.6.5.5

Proteins

dynamin-1-like protein
Refseq ID NP_957216
Protein GI 41055508
UniProt ID Q7SXN5
mRNA ID NM_200922
Length 691
RefSeq Status PROVISIONAL
MEALIPVINKLQDVFNTVGADIIQLPQIAVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVDPEDRRKTSEENGVDGEEWGKFLHTKNKIYTDFDEIRQEIENETERVSGNNKGISDEPIHLKIFSPHVVNLTLVDLPGITKVPVGDQPKDIELQIRELILKYISNPNSIILAVTAANTDMATSEALKVAREVDPDGRRTLAVVTKLDLMDAGTDAMDVLMGRVIPVKLGLIGVVNRSQLDINNKKSVADSIRDEHGFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLSAQYQSLLSSYGEPVEDMSATLLQLITKFATEYCNTIEGTAKYIETAELCGGARICYIFHETFGRTLESVDPLGGLTTIDVLTAIRNATGPRPALFVPEVSFELLVKRQVKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTSLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRMRELPTSVPRDKMAGGAQAEQEGGTGTWRGMLKKGDEGQGEEKTKLQSSIPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDSLQSELVGQLYKPALLDDLLTESEDMAQRRNEAADMLKALQKASQVIAEIRETHLW

Gene Information

Entrez Gene ID
393896
Gene Name
dynamin 1-like
Gene Symbol
dnm1l
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0030054 IEA:UniProtKB-KW C cell junction
GO:0005905 IEA:UniProtKB-KW C coated pit
GO:0031410 IEA:UniProtKB-KW C cytoplasmic vesicle
GO:0005829 ISS:UniProtKB C cytosol
GO:0005741 IEA:UniProtKB-KW C mitochondrial outer membrane
GO:0005739 ISS:UniProtKB C mitochondrion
GO:0005777 ISS:UniProtKB C peroxisome
GO:0045202 IEA:UniProtKB-KW C synapse
GO:0005525 IEA:UniProtKB-KW F GTP binding
GO:0003924 ISS:UniProtKB F GTPase activity
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0042803 ISS:UniProtKB F protein homodimerization activity
GO:0006184 ISS:UniProtKB P GTP catabolic process
GO:0003374 ISS:UniProtKB P dynamin polymerization involved in mitochondrial fission
GO:0000266 ISS:UniProtKB P mitochondrial fission

REACTOME Pathway Links

REACTOME Pathway ID Description
6175668 Apoptosis
6176358 Apoptotic execution phase

Domain Information

InterPro Annotations

Accession Description
IPR003130 Dynamin GTPase effector
IPR000375 Dynamin central domain
IPR022812 Dynamin superfamily
IPR001401 Dynamin, GTPase domain
IPR019762 Dynamin, GTPase region, conserved site
IPR020850 GTPase effector domain, GED
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
dynamin 1-like
Protein Entry
DNM1L_DANRE
UniProt ID
Q7SXN5
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity GTP + H(2)O = GDP + phosphate.
Function Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane- associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism (By similarity). {ECO:0000250}.
Similarity Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. {ECO:0000305}.
Similarity Contains 1 GED domain. {ECO:0000255|PROSITE- ProRule:PRU00720}.
Similarity Contains 1 dynamin-type G (guanine nucleotide-binding) domain. {ECO:0000305}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250}. Golgi apparatus {ECO:0000250}. Endomembrane system {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Peroxisome {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Note=Mainly cytosolic. Translocates to the mitochondrial outer membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Associated with peroxisomal membranes. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex. Binds to phospholipid membranes (By similarity). {ECO:0000250}.
Subunit Homotetramer; dimerizes through the N-terminal GTP-middle region of one molecule binding to the GED domain of another DNM1L molecule. Oligomerizes in a GTP-dependent manner to form membrane- associated tubules with a spiral pattern. Can also oligomerize to form multimeric ring-like structures (By similarity). {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011689 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
41055508 RefSeq NP_957216 691 dynamin-1-like protein

Identical Sequences to LMP011689 proteins

Reference Database Accession Length Protein Name
GI:41055508 GenBank AAH55521.1 691 Dynamin 1-like [Danio rerio]
GI:41055508 SwissProt Q7SXN5.1 691 RecName: Full=Dynamin-1-like protein [Danio rerio]

Related Sequences to LMP011689 proteins

Reference Database Accession Length Protein Name
GI:41055508 RefSeq XP_005163105.1 727 PREDICTED: dynamin-1-like protein isoform X1 [Danio rerio]
GI:41055508 RefSeq XP_005163106.1 715 PREDICTED: dynamin-1-like protein isoform X2 [Danio rerio]
GI:41055508 RefSeq XP_005163107.1 703 PREDICTED: dynamin-1-like protein isoform X3 [Danio rerio]
GI:41055508 RefSeq XP_007252911.1 714 PREDICTED: dynamin-1-like protein-like isoform X2 [Astyanax mexicanus]
GI:41055508 RefSeq XP_007252912.1 702 PREDICTED: dynamin-1-like protein-like isoform X3 [Astyanax mexicanus]
GI:41055508 RefSeq XP_007252913.1 690 PREDICTED: dynamin-1-like protein-like isoform X4 [Astyanax mexicanus]