Gene/Proteome Database (LMPD)

LMPD ID
LMP011620
Gene ID
368256
Species
Danio rerio (Zebrafish)
Gene Name
progestin and adipoQ receptor family member VII, b
Gene Symbol
paqr7b
Synonyms
mpra; paqr7
Alternate Names
membrane progestin receptor alpha-B; mPR alpha; membrane progestin receptor alpha
Chromosome
16

Proteins

membrane progestin receptor alpha-B
Refseq ID NP_899188
Protein GI 34330174
UniProt ID Q801G2
mRNA ID NM_183345
Length 354
RefSeq Status PROVISIONAL
MATVVMEQIGRLFINAQQLRQIPRFLESAFPKLPCTVMVSDVPWVFRESHIITGYRPPDQNWRYYFLTLFQRHNESVNVWTHLLASLIILVKFQELSETVDFLRDPHAQPMFILLLAAFTYLGCSALAHLLSAKSEISHYTFYFLDYVGVAVYQYGSALAHFYYVVEEEWHAQVRTFFLPASAFLAWLSCTGCCYGKYASPKLPKFVHKLFQVVPSGLAYCLDISPVLHRIYRCYSSEHWCADQAVVYHCYQVLFFLISAYFFSYPHPERWFPGRCDFIGQGHQIFHVFLVLCTLVQIEAVRLDYTERRRLYEHLHGDLAHDAVALFIFTACCSALTAFYVRKRVKTYLEEKQE

Gene Information

Entrez Gene ID
368256
Gene Name
progestin and adipoQ receptor family member VII, b
Gene Symbol
paqr7b
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IDA:ZFIN C plasma membrane
GO:0005496 IDA:ZFIN F steroid binding
GO:0003707 IDA:UniProtKB F steroid hormone receptor activity
GO:0000187 IDA:UniProtKB P activation of MAPK activity
GO:0007275 IEA:UniProtKB-KW P multicellular organismal development
GO:0007194 IDA:UniProtKB P negative regulation of adenylate cyclase activity
GO:0001556 IMP:ZFIN P oocyte maturation
GO:0048545 IDA:ZFIN P response to steroid hormone
GO:0007165 IDA:ZFIN P signal transduction
GO:0043401 IDA:GOC P steroid hormone mediated signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR004254 AdipoR/Haemolysin-III-related

UniProt Annotations

Entry Information

Gene Name
progestin and adipoQ receptor family member VII, b
Protein Entry
MPRAB_DANRE
UniProt ID
Q801G2
Species
Zebrafish

Comments

Comment Type Description
Developmental Stage In oocytes, expression is lowest in ovarian follicles at stages I and II but gradually increases after the onset of vitellogenic growth, peaking at vitellogenic stages (stage IIIB). {ECO:0000269|PubMed:15862564}.
Function Steroid membrane receptor. Signals upon progestin binding, resulting in rapid activation of MAPK and down-regulation of adenylyl cyclase activity. Interacts with steroids with varying degrees of affinity, showing specificity for activation by the maturation-inducing steroid (MIS) 4-pregnen-17,20beta-diol-3-one (17,20beta-DHP). Capable of mediating progestin-induced oocyte maturation. {ECO:0000269|PubMed:12574519, ECO:0000269|PubMed:16899559}.
Similarity Belongs to the ADIPOR family. {ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:16899559}; Multi-pass membrane protein {ECO:0000269|PubMed:16899559}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011620 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
34330174 RefSeq NP_899188 354 membrane progestin receptor alpha-B

Identical Sequences to LMP011620 proteins

Reference Database Accession Length Protein Name
GI:34330174 GenBank AAN78115.1 354 membrane progestin receptor alpha [Danio rerio]
GI:34330174 RefSeq XP_005158387.1 354 PREDICTED: membrane progestin receptor alpha-B isoform X1 [Danio rerio]
GI:34330174 SwissProt Q801G2.1 354 RecName: Full=Membrane progestin receptor alpha-B; Short=mPR alpha; AltName: Full=Progestin and adipoQ receptor family member VII, b [Danio rerio]

Related Sequences to LMP011620 proteins

Reference Database Accession Length Protein Name
GI:34330174 DBBJ BAD06917.1 354 membrane progestin receptor alpha [Carassius auratus]
GI:34330174 EMBL CDQ65218.1 354 unnamed protein product [Oncorhynchus mykiss]
GI:34330174 GenBank AAS45554.1 354 putative membrane progestin receptor alpha [Ictalurus punctatus]
GI:34330174 GenBank AFM74475.1 354 membrane progesterone receptor alpha [Pimephales promelas]
GI:34330174 RefSeq NP_001187225.1 354 putative membrane progestin receptor alpha [Ictalurus punctatus]
GI:34330174 RefSeq XP_007251814.1 379 PREDICTED: membrane progestin receptor alpha-B-like [Astyanax mexicanus]