Gene/Proteome Database (LMPD)

LMPD ID
LMP011572
Gene ID
327197
Species
Danio rerio (Zebrafish)
Gene Name
valosin containing protein
Gene Symbol
vcp
Synonyms
CDC48; wu:fd16d05; wu:fj63d11
Chromosome
5

Proteins

transitional endoplasmic reticulum ATPase
Refseq ID NP_958889
Protein GI 41393119
UniProt ID Q7ZU99
mRNA ID NM_201481
Length 806
RefSeq Status PROVISIONAL
MASGGESKNDDLSTAILKQKNRPNRLIVDESINEDNSVVSLSQAKMDELQLFRGDTVLLKGKKRRETVCIVLSDDTCSDEKVRMNRVVRNNLRVRLGDVISIQPCPDVKYGKRIHVLPIDDTVEGITGNLFEVYLKPYFLEAYRPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLNEVGYDDIGGVRKQLAQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAVANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPAIIFIDELDAIAPKREKTHGEVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIHTKNMKLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDETIDAEVMNSLAVTMDDFRWALSQSNPSALRETVVEVPNITWEDIGGLDDVKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESEANVREIFDKARQAAPCVLFFDELDSIAKARGGNVGDGGGAADRVINQILTEMDGMSSKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDEKSRIAILKANLRKSPISKDVDLDFLAKMTNGFSGADLTEICQRACKLAIRESIENEIRRERERQTNPSAMEVEEDDPVPEIRKDHFEEAMRFARRSVSDNDIRKYEMFAQTLQQSRGFGSFRFPSSNQGGSGPSQGSSGGGGGNVFNEDNDDDLYG

Gene Information

Entrez Gene ID
327197
Gene Name
valosin containing protein
Gene Symbol
vcp
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0035861 ISS:UniProtKB C site of double-strand break
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0030433 ISS:UniProtKB P ER-associated ubiquitin-dependent protein catabolic process
GO:0007049 IEA:UniProtKB-KW P cell cycle
GO:0006974 ISS:UniProtKB P cellular response to DNA damage stimulus
GO:0006302 ISS:UniProtKB P double-strand break repair
GO:0018279 ISS:UniProtKB P protein N-linked glycosylation via asparagine
GO:0016567 ISS:UniProtKB P protein ubiquitination
GO:2000058 IMP:ZFIN P regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0019985 ISS:UniProtKB P translesion synthesis
GO:0006810 IEA:UniProtKB-KW P transport

Domain Information

InterPro Annotations

Accession Description
IPR003593 AAA+ ATPase domain
IPR005938 AAA_ATPase_CDC48
IPR003960 ATPase, AAA-type, conserved site
IPR003959 ATPase, AAA-type, core
IPR009010 Aspartate decarboxylase-like domain
IPR029067 CDC48 domain 2-like
IPR003338 CDC4_N-term_subdom
IPR004201 Cdc48_dom2
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR015415 Vps4_C

UniProt Annotations

Entry Information

Gene Name
valosin containing protein
Protein Entry
Q7ZU99_DANRE
UniProt ID
Q7ZU99
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity ATP + H(2)O = ADP + phosphate.
Function Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process (By similarity). Enhances cell cycle progression and inhibits apoptosis at low temperatures. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites and promotes the recruitment of tp53bp1 at DNA damage sites. {ECO:0000250|UniProtKB:P46462, ECO:0000250|UniProtKB:P55072, ECO:0000269|PubMed:12914916}.
Induction By cold.
Similarity Belongs to the AAA ATPase family.
Subcellular Location Cytoplasm, cytosol . Nucleus . Note=Following DNA double-strand breaks, recruited to the sites of damage.
Subunit Homohexamer.

Identical and Related Proteins

Unique RefSeq proteins for LMP011572 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
41393119 RefSeq NP_958889 806 transitional endoplasmic reticulum ATPase

Identical Sequences to LMP011572 proteins

Reference Database Accession Length Protein Name
GI:41393119 GenBank AAH50488.1 806 Valosin containing protein [Danio rerio]
GI:41393119 GenBank AAH67384.1 806 Valosin containing protein [Danio rerio]
GI:41393119 GenBank AAS92631.1 806 valosin-containing protein [Danio rerio]
GI:41393119 SwissProt Q7ZU99.1 806 RecName: Full=Transitional endoplasmic reticulum ATPase; Short=TER ATPase; AltName: Full=Protein CDC48; AltName: Full=Valosin-containing protein; Short=VCP [Danio rerio]

Related Sequences to LMP011572 proteins

Reference Database Accession Length Protein Name
GI:41393119 DBBJ BAC87740.1 806 CDC48, partial [Danio rerio]
GI:41393119 GenBank AHH39696.1 806 Transitional endoplasmic reticulum ATPase [Ictalurus punctatus]
GI:41393119 RefSeq XP_006626794.1 806 PREDICTED: transitional endoplasmic reticulum ATPase-like [Lepisosteus oculatus]
GI:41393119 RefSeq XP_006784235.1 806 PREDICTED: transitional endoplasmic reticulum ATPase-like [Neolamprologus brichardi]
GI:41393119 RefSeq XP_007238029.1 806 PREDICTED: transitional endoplasmic reticulum ATPase [Astyanax mexicanus]
GI:41393119 RefSeq XP_008280227.1 806 PREDICTED: transitional endoplasmic reticulum ATPase [Stegastes partitus]