Gene/Proteome Database (LMPD)

LMPD ID
LMP011560
Gene ID
325179
Species
Danio rerio (Zebrafish)
Gene Name
inositol polyphosphate phosphatase-like 1a
Gene Symbol
inppl1a
Synonyms
fc58a04; wu:fc58a04; zgc:198309
Alternate Names
phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A; ship2a; SHIP-2A; INPPL1-A; SH2 domain-containing inositol phosphatase 2A; SH2-domain-containing inositol 5-phosphatase 2a', "SH2 domain-containing inositol 5'-phosphatase 2A", "SH2 domain-containing inositol-5'-phosphatase 2A;,inositol polyphosphate phosphatase-like protein 1A; phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2A
Chromosome
15
EC Number
3.1.3.86

Proteins

phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A
Refseq ID NP_001034893
Protein GI 89886281
UniProt ID Q2I6J1
mRNA ID NM_001039804
Length 1266
RefSeq Status PROVISIONAL
MAAVGPASPPPPPLWMHRDLSRTAAEELLARAGRDGSFLVRDSESVSGAYALCVLFQKHVHTYRILPDEENFLAVQTSQGVQPKRFKTLPELIQLYLQPSQGLVTTLLYPVEREETTEDRDYSDGEDEKPPPPPRTASTSSMTGSALVSTDTPPENVTAANGLSTISHEYLKGNYALDLEAVKQGANSLPHLNKTLLSSCKRLHGEVDKVLCGLEILSKVFDQQSASMVSRMIQQSMSQGGDQELEHLVTKLAILKDLLSSIEKKALKALQDMSSSTPAISPLLSIRNKVIPVQTFEVKLDVYLADLTKIGKSQKYSLSVDVEGGKLVVMKKMKDAQEDWNTFTHDKIRQLIKSQRVQNKLGIVFEKEKDKSQRKDFIFASAKKREAFCQLLQLMKNKHSNQDEPDMISIFIGTWNMGSVPAPKPLGSWILSRGLGKTLDEMAVTIPHDIYVFGTQENSVCDKEWVETLRCSLKEYTDMEYKPIAVQTLWNIKIVVLVKAEHENRISHVGMSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKIHRRNQNYLDILRQLSLGDKQLNSFDISLRFTHLFWFGDLNYRLDMDIQEILNYINRKEFDPLLKVDQLNLEREKNKIFLRFAEEEISYPPTYRYERGSRDTYVWQKQKATGMRTNVPSWCDRILWKSYPETHIVCNSYGCTDDIVTSDHSPVFGTFEVGVTSQFVSKKGLPKSSEQAYIEFENIEAIVKTASRTKFFIEFYSTCLEEFKKSYENDTQSSDNVNFLRVGWSSKQLTTLKPILSDIEYLQDQHLLLTVKSLDGYESYGECVLALKSMIGSTAQQFHTYLSHRGEETGNIRGSMRVRVPSERMGTRERLYEWISVDKDDMGGPKGRTLPPRTSHDYVKPTSSSSSRKHGSAELSRVSEEGEKSSTSRHPHTKEENTHNRGKQDPFESDATTCKNSFNNPAYYILEGVPNQSAALASDILPGSALPPLANKTTAPPAGSVGKSKPPSGSSAQGRWQTSGRSVRPISEEGSSEDDGNIVPHTGSLNRPPPDFPPPPLPKAALEMSENSFGKPRVFSDLADGKIPPPSKPLVSPGLTPPPGGAPGGGVAFCIESPPVLSPNSAPFRRGGGASALDDQSCSVLQMAKTLSEVEYPSGRERGASQGPTGPQLRGLSFPSHPIQEESIAEDLPEEGGLWGAESSSSSLSVDCSVGEWLQKLGLQHYEEGLLHNGWDDLEFLSDITEEDLEEAGVRDPAHKKILLASLKQQQK

Gene Information

Entrez Gene ID
325179
Gene Name
inositol polyphosphate phosphatase-like 1a
Gene Symbol
inppl1a
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042995 IEA:UniProtKB-KW C cell projection
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005856 IEA:UniProtKB-KW C cytoskeleton
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0030509 IMP:ZFIN P BMP signaling pathway
GO:0007155 IEA:UniProtKB-KW P cell adhesion
GO:0002376 IEA:UniProtKB-KW P immune system process
GO:0040037 IMP:ZFIN P negative regulation of fibroblast growth factor receptor signaling pathway
GO:0090024 IGI:ZFIN P negative regulation of neutrophil chemotaxis
GO:0046856 IEA:InterPro P phosphatidylinositol dephosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
dre00562 Inositol phosphate metabolism
dre04910 Insulin signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase
IPR000300 Inositol polyphosphate-related phosphatase
IPR000980 SH2 domain
IPR001660 Sterile alpha motif domain
IPR021129 Sterile alpha motif, type 1
IPR013761 Sterile alpha motif/pointed domain

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate phosphatase-like 1a
Protein Entry
SHP2A_DANRE
UniProt ID
Q2I6J1
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 3,4,5- triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4- diphosphate + phosphate.
Domain The NPXY sequence motif found in many tyrosine- phosphorylated proteins is required for the specific binding of the PID domain. {ECO:0000250}.
Domain The SH2 domain interacts with tyrosine phosphorylated forms of proteins. {ECO:0000250}.
Function Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. Part of a signaling pathway that regulates actin cytoskeleton remodeling. Required for the maintenance and dynamic remodeling of actin structures as well as in endocytosis, having a major impact on ligand-induced EGFR internalization and degradation. Participates in regulation of cortical and submembraneous actin. Regulates cell adhesion and cell spreading. Acts as a negative regulator of the FC-gamma-RIIA receptor (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6 (By similarity). {ECO:0000250}.
Ptm Tyrosine phosphorylated by the members of the SRC family after exposure to a diverse array of extracellular stimuli.
Similarity Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase family. {ECO:0000305}.
Similarity Contains 1 SAM (sterile alpha motif) domain. {ECO:0000255|PROSITE-ProRule:PRU00184}.
Similarity Contains 1 SH2 domain. {ECO:0000255|PROSITE- ProRule:PRU00191}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011560 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
89886281 RefSeq NP_001034893 1266 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A

Identical Sequences to LMP011560 proteins

Reference Database Accession Length Protein Name
GI:89886281 GenBank ABB84851.1 1266 SH2-domain-containing inositol 5-phosphatase 2a [Danio rerio]

Related Sequences to LMP011560 proteins

Reference Database Accession Length Protein Name
GI:89886281 GenBank AAI71582.1 1266 Wu:fc58a04 [Danio rerio]
GI:89886281 GenBank AHH37513.1 1256 Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A [Ictalurus punctatus]
GI:89886281 RefSeq XP_006628198.1 1243 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A-like [Lepisosteus oculatus]
GI:89886281 RefSeq XP_007247706.1 1301 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A-like [Astyanax mexicanus]
GI:89886281 RefSeq XP_008299632.1 1262 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 [Stegastes partitus]
GI:89886281 SwissProt Q2I6J1.2 1266 RecName: Full=Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A; AltName: Full=Inositol polyphosphate phosphatase-like protein 1A; Short=INPPL1-A; AltName: Full=SH2 domain-containing inositol 5'-phosphatase 2A; Short=SH2 domain-containing inositol phosphatase 2A; Short=SHIP-2A [Danio rerio]