Gene/Proteome Database (LMPD)

LMPD ID
LMP011511
Gene ID
140615
Species
Danio rerio (Zebrafish)
Gene Name
fatty acid desaturase 2
Gene Symbol
fads2
Synonyms
Fadsd6; DRD5/D6; wu:fb64c04; wu:fb69e08; zgc:112502
Alternate Names
fatty acid desaturase 2; D5D/D6D fatty acid desaturase; delta-6 fatty acyl desaturase; delta-5/Delta-6 fatty acid desaturase; delta(5)/Delta(6) fatty acid desaturase
Chromosome
25
EC Number
1.14.19.-

Proteins

fatty acid desaturase 2
Refseq ID NP_571720
Protein GI 42476248
UniProt ID Q9DEX7
mRNA ID NM_131645
Length 444
RefSeq Status PROVISIONAL
MGGGGQQTDRITDTNGRFSSYTWEEMQKHTKHGDQWVVVERKVYNVSQWVKRHPGGLRILGHYAGEDATEAFTAFHPNLQLMRKYLKPLLIGELEASEPSQDRQKNAALVEDFRALRERLEAEGCFKTQPLFFALHLGHILLLEAIAFVMVWYFGTGWINTLIVAVILATAQSQAGWLQHDFGHLSVFKTSGMNHLVHKFVIGHLKGASAGWWNHRHFQHHAKPNIFKKDPDVNMLNAFVVGNVQPVEYGVKKIKHLPYNHQHKYFFFIGPPLLIPVYFQFQIFHNMISHGMWVDLLWCISYYVRYFLCYTQFYGVFWAIILFNFVRFMESHWFVWVTQMSRIPMNIDYEQNQDWLSMQLVATCNIEQSAFNDWFSGHLNFQIEHHLFPTMPRHNYWRAAPRVRSLCEKYGVKYQEKTLYGAFADIIRSLEKSGELWLDAYLNK

Gene Information

Entrez Gene ID
140615
Gene Name
fatty acid desaturase 2
Gene Symbol
fads2
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0016717 IEA:InterPro F oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
GO:0001889 IMP:ZFIN P liver development
GO:0006636 IEA:UniProtKB-UniPathway P unsaturated fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
dre01040 Biosynthesis of unsaturated fatty acids
dre01212 Fatty acid metabolism
dre03320 PPAR signaling pathway
dre00592 alpha-Linolenic acid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR001199 Cytochrome b5-like heme/steroid binding domain
IPR005804 Fatty acid desaturase, type 1
IPR012171 Fatty acid/sphingolipid desaturase

UniProt Annotations

Entry Information

Gene Name
fatty acid desaturase 2
Protein Entry
FADS2_DANRE
UniProt ID
Q9DEX7
Species
Zebrafish

Comments

Comment Type Description
Domain The histidine box domains may contain the active site and/or be involved in metal ion binding.
Function Fatty acid desaturase with both Delta(5) and Delta(6) activities. Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) (By similarity). {ECO:0000250}.
Pathway Lipid metabolism; polyunsaturated fatty acid biosynthesis.
Similarity Belongs to the fatty acid desaturase family. {ECO:0000305}.
Similarity Contains 1 cytochrome b5 heme-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00279}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011511 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
42476248 RefSeq NP_571720 444 fatty acid desaturase 2

Identical Sequences to LMP011511 proteins

Reference Database Accession Length Protein Name
GI:42476248 GenBank AAH49438.1 444 Fatty acid desaturase 2 [Danio rerio]

Related Sequences to LMP011511 proteins

Reference Database Accession Length Protein Name
GI:42476248 GenBank ACW02990.1 444 Sequence 18 from patent US 7550286
GI:42476248 GenBank AEF64665.1 444 Sequence 370 from patent US 7932077
GI:42476248 GenBank AEF64666.1 444 Sequence 373 from patent US 7932077
GI:42476248 GenBank AEH20512.1 444 Sequence 30 from patent US 7951994
GI:42476248 GenBank AEW32718.1 444 Sequence 15 from patent US 8071341
GI:42476248 GenBank AGU18509.1 444 Sequence 373 from patent US 8518674