Gene/Proteome Database (LMPD)

LMPD ID
LMP011489
Gene ID
30724
Species
Danio rerio (Zebrafish)
Gene Name
maternal embryonic leucine zipper kinase
Gene Symbol
melk
Synonyms
fb71b01; fe01f04; wu:fb71b01; wu:fe01f04
Alternate Names
maternal embryonic leucine zipper kinase; zMelk; protein kinase PK38
Chromosome
1
EC Number
2.7.11.1

Proteins

maternal embryonic leucine zipper kinase
Refseq ID NP_996771
Protein GI 46195779
UniProt ID F1QGZ6
mRNA ID NM_206888
Length 676
RefSeq Status PROVISIONAL
MPVDSTSELLRHYEVYETIGSGGFAKVKLGRHKLTGEKVAIKIMEKKDLGDDLPRVKIEIEAMKNLSHQHVCRLYHVIETTSKIYMVLEYCPGGELFDYIIAKDRLSEEETRVFFRQIISALAYVHSQGYAHRDLKPENLLIDEDHNLKLIDFGLCAKPKGGLGFELLTCCGSPAYAAPELIQGKAYIGSEADVWSMGVLLYALLCGFLPFDDDNCMVLYRKITRGKYSNPHWLSPSSILLLNQMMQVDPKRRLTVKHLLDHPWAMRGYSTPVEWHSKYPLGHIDEDCITEMAVTFKQSKQRTIQLVSEWKYDQITATYLLLLAKKRQGRPVRLRAECPVIDIVCSPLQDMQLKKSLRFTEDDDGVHPVVLGSMVFPPDCYDDENPWTPLTPKNTHTTNTPRMKLYPETTEKWNEMAYSPVIEHSRPCRQKPERRDRTKENKENLAVPGTDGDVFALPAPRTPTSSRKVKSNRTVMTTPNHNNNKSSEVNKGAGSATKEGSRRREVEQQQNGQQGELNMLAFSPERRSRSLDLAGCQVDSGQKRKGGKVFGSLERGLDKVITMLTPSKKRGPRDGPRKIKAQYNVTLTNQTNADQVLNQILSILPEKNVDFVQKGYTLKCHTQSDFGKVTMQFELEVCLLQKPEVVGIRRQRLKGDAWVYKHPVEDILSSSSQWSA

Gene Information

Entrez Gene ID
30724
Gene Name
maternal embryonic leucine zipper kinase
Gene Symbol
melk
Species
Danio rerio

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005938 ISS:UniProtKB C cell cortex
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0005509 ISS:UniProtKB F calcium ion binding
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0004715 ISS:UniProtKB F non-membrane spanning protein tyrosine kinase activity
GO:0004674 ISS:UniProtKB F protein serine/threonine kinase activity
GO:0006915 ISS:UniProtKB P apoptotic process
GO:0007049 IEA:UniProtKB-KW P cell cycle
GO:0008283 ISS:UniProtKB P cell proliferation
GO:0048821 IMP:ZFIN P erythrocyte development
GO:0030097 IMP:UniProtKB P hemopoiesis
GO:0061351 ISS:UniProtKB P neural precursor cell proliferation
GO:0018108 ISS:GOC P peptidyl-tyrosine phosphorylation
GO:0043065 ISS:UniProtKB P positive regulation of apoptotic process
GO:0046777 ISS:UniProtKB P protein autophosphorylation
GO:0008016 IMP:ZFIN P regulation of heart contraction

Domain Information

InterPro Annotations

Accession Description
IPR028375 KA1 domain/Ssp2 C-terminal domain
IPR001772 Kinase associated domain 1 (KA1)
IPR000719 Protein kinase domain
IPR017441 Protein kinase, ATP binding site
IPR011009 Protein kinase-like domain
IPR008271 Serine/threonine-protein kinase, active site
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
maternal embryonic leucine zipper kinase
Protein Entry
MELK_DANRE
UniProt ID
F1QGZ6
Species
Zebrafish

Comments

Comment Type Description
Catalytic Activity ATP + a protein = ADP + a phosphoprotein.
Domain The KA1 domain mediates binding to phospholipids and targeting to membranes. {ECO:0000250}.
Enzyme Regulation Activated by autophosphorylation of the T-loop at Thr-169 and Ser-173: in contrast to other members of the SNF1 subfamily, phosphorylation at Thr-169 is not mediated by STK11/LKB1 but via autophosphorylation instead.
Function Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation (By similarity). Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis. {ECO:0000250, ECO:0000269|PubMed:16024803}.
Ptm Autophosphorylated: autophosphorylation of the T-loop at Thr- 169 and Ser-173 is required for activation. {ECO:0000250}.
Similarity Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. {ECO:0000305}.
Similarity Contains 1 KA1 (kinase-associated) domain. {ECO:0000255|PROSITE-ProRule:PRU00565}.
Similarity Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity Strongly expressed in the eye, gill, kidney, spleen, muscle, ovary and testis and weakly in the heart, liver, and gut. Expressed in the brain and lateral mesoderm at 12 hours post-fertilization (hpf). {ECO:0000269|PubMed:16024803}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011489 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
46195779 RefSeq NP_996771 676 maternal embryonic leucine zipper kinase

Identical Sequences to LMP011489 proteins

Reference Database Accession Length Protein Name
GI:46195779 GenBank AAH50520.1 676 Maternal embryonic leucine zipper kinase [Danio rerio]

Related Sequences to LMP011489 proteins

Reference Database Accession Length Protein Name
GI:46195779 DBBJ BAC75706.1 676 similar to maternal embryonic leucine zipper kinase [Danio rerio]
GI:46195779 RefSeq XP_003978135.1 820 PREDICTED: maternal embryonic leucine zipper kinase-like [Takifugu rubripes]
GI:46195779 RefSeq XP_004564337.1 684 PREDICTED: maternal embryonic leucine zipper kinase-like [Maylandia zebra]
GI:46195779 RefSeq XP_005456903.1 684 PREDICTED: maternal embryonic leucine zipper kinase [Oreochromis niloticus]
GI:46195779 RefSeq XP_006787333.1 684 PREDICTED: maternal embryonic leucine zipper kinase-like [Neolamprologus brichardi]
GI:46195779 SwissProt F1QGZ6.1 676 RecName: Full=Maternal embryonic leucine zipper kinase; Short=zMelk; AltName: Full=Protein kinase PK38 [Danio rerio]