Gene/Proteome Database (LMPD)

LMPD ID
LMP011423
Gene ID
834630
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
ubiquitin-like modifier-activating enzyme atg7
Gene Symbol
APG7
Synonyms
ATAPG7; ATATG7; ATG7; AUTOPHAGY 7; AUTOPHAGY-RELATED 7; K15I22.10; K15I22_10
Alternate Names
ubiquitin-like modifier-activating enzyme atg7
Chromosome
5

Proteins

ubiquitin-like modifier-activating enzyme atg7
Refseq ID NP_568652
Protein GI 18422607
UniProt ID Q94CD5
mRNA ID NM_123958
Length 697
RefSeq Status REVIEWED
MAEKETPAIILQFAPLNSSVDEGFWHSFSSLKLDKLGIDDSPISITGFYGPCGHPQVSNHLTLLSESLPLDEQSLIASTSHGNRNKCPVPGILYNTNTVESFNKLDKQSLLKAEANKIWEDIQSGKALEDPSVLPRFLVISFADLKKWSFRYWFAFPAFVLDPPVSLIELKPASEYFSSEEAESVSAACNDWRDSDLTTDVPFFLVSVSSDSKASIRHLKDLEACQGDHQKLLFGFYDPCHLPSNPGWPLRNYLALIRSRWNLETVWFFCYRESRGFADLNLSLVGQASITLSSGESAETVPNSVGWELNKGKRVPRSISLANSMDPTRLAVSAVDLNLKLMRWRALPSLNLNVLSSVKCLLLGAGTLGCQVARTLMGWGIRNITFVDYGKVAMSNPVRQSLYNFEDCLGRGEFKAVAAVKSLKQIFPAMETSGVVMAIPMPGHPISSQEEDSVLGDCKRLSELIESHDAVFLLTDTRESRWLPSLLCANANKIAINAALGFDSYMVMRHGAGPTSLSDDMQNLDINKTNTQRLGCYFCNDVVAPQDSMTDRTLDQQCTVTRPGLAPIAGALAVELLVGVLQHPLGINAKGDNSSLSNTGNNDDSPLGILPHQIRGSVSQFSQITLLGQASNSCTACSETVISEYRERGNSFILEAINHPTYLEDLTGLTELKKAANSFNLDWEDDDTDDDDVAVDL

Gene Information

Entrez Gene ID
834630
Gene Name
ubiquitin-like modifier-activating enzyme atg7
Gene Symbol
APG7
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:TAIR C cytosol
GO:0019779 ISS:TAIR F Atg8 activating enzyme
GO:0006914 ISS:TAIR P autophagy
GO:0050832 IEP:TAIR P defense response to fungus
GO:0010150 IMP:TAIR P leaf senescence
GO:0006497 ISS:TAIR P protein lipidation
GO:0015031 IEA:UniProtKB-KW P protein transport

KEGG Pathway Links

KEGG Pathway ID Description
ath04140 Regulation of autophagy
ko04140 Regulation of autophagy

Domain Information

InterPro Annotations

Accession Description
IPR009036 Molybdenum cofactor biosynthesis, MoeB
IPR016040 NAD(P)-binding domain
IPR000594 UBA/THIF-type NAD/FAD binding fold
IPR006285 Ubiquitin-like modifier-activating enzyme Atg7

UniProt Annotations

Entry Information

Gene Name
ubiquitin-like modifier-activating enzyme atg7
Protein Entry
ATG7_ARATH
UniProt ID
Q94CD5
Species
Arabidopsis

Comments

Comment Type Description
Developmental Stage Up-regulated during leaf senescence. {ECO:0000269|PubMed:12070171}.
Domain The C-terminal residues are required for homodimerization, as well as the interactions with ATG3, ATG8 and ATG12. {ECO:0000250}.
Domain The GxGxxG motif is important for the function, possibly through binding with ATP.
Function E1-like activating enzyme involved in the 2 ubiquitin- like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process. {ECO:0000269|PubMed:12070171}.
Sequence Caution Sequence=BAB09318.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the ATG7 family. {ECO:0000305}.
Subunit Homodimer. Interacts with ATG8 through a thioester bond between Cys-558 and the C-terminal glycine of ATG8 and with ATG12 through a thioester bond between Cys-558 and the C-terminal glycine of ATG12. Interacts also with ATG3 (By similarity). {ECO:0000250}.
Tissue Specificity Constitutively expressed (at protein level). {ECO:0000269|PubMed:12070171}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011423 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18422607 RefSeq NP_568652 697 ubiquitin-like modifier-activating enzyme atg7

Identical Sequences to LMP011423 proteins

Reference Database Accession Length Protein Name
GI:18422607 DBBJ BAB88385.1 697 autophagy 7 [Arabidopsis thaliana]
GI:18422607 GenBank AAM70190.1 697 autophagy APG7 [Arabidopsis thaliana]
GI:18422607 GenBank AAN12897.1 697 putative ubiquitin-activating enzyme E1 [Arabidopsis thaliana]
GI:18422607 GenBank AFG94681.1 697 Sequence 340 from patent US 8148088
GI:18422607 gnl TAIR 697 ubiquitin-like modifier-activating enzyme atg7 [Arabidopsis thaliana]
GI:18422607 SwissProt Q94CD5.1 697 RecName: Full=Ubiquitin-like modifier-activating enzyme atg7; AltName: Full=ATG12-activating enzyme E1 atg7; AltName: Full=Autophagy-related protein 7; Short=AtAPG7 [Arabidopsis thaliana]

Related Sequences to LMP011423 proteins

Reference Database Accession Length Protein Name
GI:18422607 DBBJ BAB09318.1 678 ubiquitin activating enzyme E1-like protein [Arabidopsis thaliana]
GI:18422607 GenBank EFH41478.1 697 hypothetical protein ARALYDRAFT_916858 [Arabidopsis lyrata subsp. lyrata]
GI:18422607 RefSeq XP_002865219.1 697 hypothetical protein ARALYDRAFT_916858 [Arabidopsis lyrata subsp. lyrata]
GI:18422607 RefSeq XP_010441657.1 696 PREDICTED: ubiquitin-like modifier-activating enzyme atg7 [Camelina sativa]
GI:18422607 RefSeq XP_010481518.1 695 PREDICTED: ubiquitin-like modifier-activating enzyme atg7 [Camelina sativa]
GI:18422607 RefSeq XP_010494743.1 697 PREDICTED: ubiquitin-like modifier-activating enzyme atg7 [Camelina sativa]