Gene/Proteome Database (LMPD)

LMPD ID
LMP011415
Gene ID
818994
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
5-inositol-phosphate phosphatase
Gene Symbol
AT2G43900
Synonyms
F6E13.3
Alternate Names
5-inositol-phosphate phosphatase
Chromosome
2
EC Number
3.1.3.56

Proteins

5-inositol-phosphate phosphatase
Refseq ID NP_181918
Protein GI 240254645
UniProt ID O80560
mRNA ID NM_129952
Length 1316
RefSeq Status REVIEWED
MDIINNNHRDENDDDEEEALSAMSSVPPPRKIHSYSHQLRATGQKGHHRQRQHSLDDIPKITEIVSGCGISGDSSDDEFYPYATTTNSSSFPFTGGDTGDSDDYLHQPEIGEDFQPLPEFVGSGGGVGMFKVPTRSPLHSARPPCLELRPHPLKETQVGRFLRNIACTETQLWAGQESGVRFWNFDDAFEPGCGLSGRVQRGDEDAAPFQESASTSPTTCLMVDNGNRLVWSGHKDGKIRSWKMDYVLDDGDDSPFKEGLAWQAHKGPVNSVIMSSYGDLWSCSEGGVIKIWTWESMEKSLSLRLEEKHMAALLVERSGIDLRAQVTVNGTCNISSSEVKCLLADNVRSKVWAAQLQTFSLWDGRTKELLKVFNSEGQTENRVDMPLGQDQPAAEDEMKAKIASTSKKEKPHGFLQRSRNAIMGAADAVRRVATRGGGAYEDAKRTEAMVLAGDGMIWTGCTNGLLIQWDGNGNRLQDFRHHQCAVLCFCTFGERIYIGYVSGHIQIIDLEGNLIAGWVAHNNAVIKMAAADGYIFSLATHGGIRGWPVISPGPLDGIIRSELAEKERTYAQTDSVRILTGSWNVGQGKASHDALMSWLGSVASDVGILVVGLQEVEMGAGFLAMSAAKESVGGNEGSTIGQYWIDTIGKTLDEKAVFERMGSRQLAGLLISLWVRKNLRTHVGDIDVAAVPCGFGRAIGNKGGVGLRIRVFDRIMCFINCHLAAHLEAVNRRNADFDHIYKTMSFTRSSNAHNAPAAGVSTGSHTTKSANNANVNTEETKQDLAEADMVVFFGDFNYRLFGISYDEARDFVSQRSFDWLREKDQLRAEMKAGRVFQGMREAIITFPPTYKFERHRPGLGGYDSGEKKRIPAWCDRVIFRDTRTSPESECSLDCPVVASIMLYDACMDVTESDHKPVRCKFHVKIEHVDRSVRRQEFGRIIKTNEKVRALLNDLRYVPETIVSSNSIVLQNQDTFVLRITNKCVKENAVFRILCEGQSTVREDEDTLELHPLGSFGFPRWLEVMPAAGTIKPDSSVEVSVHHEEFHTLEEFVDGIPQNWWCEDTRDKEAILVVNVQGGCSTETVCHRVHVRHCFSAKNLRIDSNPSNSKSQSLKKNEGDSNSKSSKKSDGDSNSKSSKKSDGDSNSKSSKKSDGDSNSKSSKKSDGDSNSKSSKKSDGDSNSKSSKKSDGDSNSKSSKKSDGDSCSKSQKKSDGDTNSKSQKKGDGDSSSKSHKKNDGDSSSKSHKKNDGDSSSKSHKKSDGDSSSKSHKKSEGDSSSKSHKKNDGDSSSSYKSQSGKKNSNSSTVEESRNNHNKR

Gene Information

Entrez Gene ID
818994
Gene Name
5-inositol-phosphate phosphatase
Gene Symbol
AT2G43900
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0052659 IEA:UniProtKB-EC F inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
GO:0052658 IEA:UniProtKB-EC F inositol-1,4,5-trisphosphate 5-phosphatase activity
GO:0004445 IEA:UniProtKB-EC F inositol-polyphosphate 5-phosphatase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0046856 IEA:InterPro P phosphatidylinositol dephosphorylation

REACTOME Pathway Links

REACTOME Pathway ID Description
6254053 Rho GTPase cycle
6254054 Signaling by Rho GTPases
6254349 Synthesis of IP2, IP, and Ins in the cytosol
6254351 Synthesis of IP3 and IP4 in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase
IPR000300 Inositol polyphosphate-related phosphatase
IPR017986 WD40-repeat-containing domain
IPR015943 WD40/YVTN repeat-like-containing domain
IPR001680 WD40_repeat

UniProt Annotations

Entry Information

Gene Name
5-inositol-phosphate phosphatase
Protein Entry
IP5PC_ARATH
UniProt ID
O80560
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O80560-1; Sequence=Displayed; Name=2; IsoId=O80560-2; Sequence=VSP_036156, VSP_036157, VSP_036158, VSP_036159, VSP_036160; Note=No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=223 uM for Ins(1,4,5)P3 {ECO:0000269|PubMed:15574849};
Catalytic Activity 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H(2)O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate.
Catalytic Activity D-myo-inositol 1,4,5-trisphosphate + H(2)O = myo-inositol 1,4-bisphosphate + phosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:15574849};
Function Converts inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) to inositol 1,4-bisphosphate. {ECO:0000269|PubMed:15574849}.
Induction Not induced by stresses. {ECO:0000269|PubMed:15574849}.
Sequence Caution Sequence=AEC10342.1; Type=Frameshift; Positions=1278; Evidence={ECO:0000305}; Sequence=CAC81919.1; Type=Frameshift; Positions=953, 998; Evidence={ECO:0000305};
Similarity Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type I family. {ECO:0000305}.
Similarity Contains 5 WD repeats. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011415 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
240254645 RefSeq NP_181918 1316 5-inositol-phosphate phosphatase

Identical Sequences to LMP011415 proteins

Reference Database Accession Length Protein Name
GI:240254645 GenBank AEC10342.1 1316 5-inositol-phosphate phosphatase [Arabidopsis thaliana]

Related Sequences to LMP011415 proteins

Reference Database Accession Length Protein Name
GI:240254645 GenBank AAV87314.1 1305 inositol polyphosphate 5-phosphatase [Arabidopsis thaliana]
GI:240254645 GenBank AAV87318.1 1305 inositol polyphosphate 5-phosphatase [Arabidopsis thaliana]
GI:240254645 GenBank EOA29354.1 1294 hypothetical protein CARUB_v10025640mg [Capsella rubella]
GI:240254645 gnl TIGR 1305 putative inositol polyphosphate 5'-phosphatase [Arabidopsis thaliana]
GI:240254645 RefSeq XP_006296456.1 1294 hypothetical protein CARUB_v10025640mg [Capsella rubella]
GI:240254645 SwissProt O80560.1 1305 RecName: Full=Type I inositol 1,4,5-trisphosphate 5-phosphatase 12; Short=At5PTase12 [Arabidopsis thaliana]