Gene/Proteome Database (LMPD)

LMPD ID
LMP011307
Gene ID
816814
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
squalene epoxidase 2
Gene Symbol
SQE2
Synonyms
squalene epoxidase 2; T20K9.4; T20K9_4
Alternate Names
squalene epoxidase 2
Chromosome
2
EC Number
1.14.13.132

Proteins

squalene epoxidase 2
Refseq ID NP_179868
Protein GI 15227757
UniProt ID O81000
mRNA ID NM_127848
Length 585
RefSeq Status REVIEWED
MKPFVIRNLPRFQSTLRSSLLYTNHRPSSRFSLSTRRFTTGATYIRRWKATAAQTLKLSAVNSTVMMKPAKIALDQFIASLFTFLLLYILRRSSNKNKKNRGLVVSQNDTVSKNLETEVDSGTDVIIVGAGVAGSALAHTLGKEGRRVHVIERDFSEQDRIVGELLQPGGYLKLIELGLEDCVKKIDAQRVLGYVLFKDGKHTKLAYPLETFDSDVAGRSFHNGRFVQRMREKALTLSNVRLEQGTVTSLLEEHGTIKGVRYRTKEGNEFRSFAPLTIVCDGCFSNLRRSLCKPKVDVPSTFVGLVLENCELPFANHGHVVLGDPSPILMYPISSSEVRCLVDVPGQKLPPIANGEMAKYLKTRVAPQVPTKVREAFITAVEKGNIRTMPNRSMPADPIPTPGALLLGDAFNMRHPLTGGGMTVALADIVVLRDLLRPIRNLNDKEALSKYIESFYTLRKPVASTINTLADALYKVFLASSDEARTEMREACFDYLSLGGVFSSGPVALLSGLNPRPLSLVLHFFAVAIYAVCRLMLPFPSIESFWLGARIISSASSIIFPIIKAEGVRQMFFPRTIPAIYRAPP

Gene Information

Entrez Gene ID
816814
Gene Name
squalene epoxidase 2
Gene Symbol
SQE2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005739 IEA:UniProtKB-KW C mitochondrion
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0004506 IEA:UniProtKB-EC F squalene monooxygenase activity

KEGG Pathway Links

KEGG Pathway ID Description
ath00909 Sesquiterpenoid and triterpenoid biosynthesis
ath00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
6254329 Activation of gene expression by SREBF (SREBP)
6254036 Cholesterol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR003042 Aromatic-ring hydroxylase-like
IPR003953 FAD binding domain
IPR013698 Squalene_epoxidase

UniProt Annotations

Entry Information

Gene Name
squalene epoxidase 2
Protein Entry
ERG15_ARATH
UniProt ID
O81000
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Squalene + NADPH + O(2) = (3S)-2,3-epoxy-2,3- dihydrosqualene + NADP(+) + H(2)O. {ECO:0000269|PubMed:17426032}.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Function Catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. Produces primarily oxidosqualene. {ECO:0000269|PubMed:17426032}.
Pathway Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 2/3.
Similarity Belongs to the squalene monooxygenase family. {ECO:0000305}.
Subcellular Location Mitochondrion membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}.
Tissue Specificity Expressed mainly in inflorescences. Detected in seedlings, leaves, stems, and siliques. {ECO:0000269|PubMed:17426032}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011307 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15227757 RefSeq NP_179868 585 squalene epoxidase 2

Identical Sequences to LMP011307 proteins

Reference Database Accession Length Protein Name
GI:15227757 GenBank AAW17574.1 585 Sequence 1 from patent US 6822142
GI:15227757 GenBank ACV99097.1 585 Sequence 1 from patent US 7544863
GI:15227757 GenBank AEC07362.1 585 squalene epoxidase 2 [Arabidopsis thaliana]
GI:15227757 GenBank AED65460.1 585 Sequence 1 from patent US 7906710
GI:15227757 gnl TIGR 585 putative squalene epoxidase [Arabidopsis thaliana]
GI:15227757 SwissProt O81000.1 585 RecName: Full=Squalene epoxidase 2, mitochondrial; Short=AtSQE2; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP011307 proteins

Reference Database Accession Length Protein Name
GI:15227757 GenBank EFH56723.1 561 predicted protein [Arabidopsis lyrata subsp. lyrata]
GI:15227757 GenBank EOA26359.1 587 hypothetical protein CARUB_v10022880mg [Capsella rubella]
GI:15227757 GenBank ESQ46200.1 603 hypothetical protein EUTSA_v10000099mg [Eutrema salsugineum]
GI:15227757 RefSeq XP_002880464.1 561 predicted protein [Arabidopsis lyrata subsp. lyrata]
GI:15227757 RefSeq XP_006404747.1 603 hypothetical protein EUTSA_v10000099mg [Eutrema salsugineum]
GI:15227757 RefSeq XP_010472280.1 599 PREDICTED: squalene epoxidase 2, mitochondrial [Camelina sativa]