Gene/Proteome Database (LMPD)

LMPD ID
LMP011301
Gene ID
819217
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
sphingoid long-chain bases kinase 2
Gene Symbol
AT2G46090
Synonyms
T3F17.26
Alternate Names
sphingoid long-chain bases kinase 2
Chromosome
2
EC Number
2.7.-.-
Summary
Encodes a putative sphingosine kinase (SphK) containing the five conserved domains (C1-C5) previously identified in SphKs.
Orthologs
View orthologs and multiple alignments for AT2G46090

Proteins

sphingoid long-chain bases kinase 2
Refseq ID NP_566064
Protein GI 18406971
UniProt ID O82359
mRNA ID NM_130172
Length 364
RefSeq Status REVIEWED
MLRSTCCTPLCPFTAKQPSFLRKQQRITSDRFTFRGGGGGDAAAVVSSSGLRDLVFVVNPQGANGRTAKEWKKLLPHLRSRLGKDCNVSELLTSGPSHAIDITREAIRDGADAVIAVGGDGTLHEVVNGFFWEGKPVGYLSGEASRSTALGLIPLGTGSDFARTFGWNNDPCEAVERIARGMRSRIDVGVIDKEGKDLHYFINVADVHLSAKAGFYASKYKKFGNLCYVIGALQAFMGHHNQDMRIRVNGGEWEIYPQVTALCVGNAKYFGGGMKITPNAIPGNGNLEVVVLQNFKWYDFVLKLHKLYNGTHLSVNNVTSRSVQSIEVEEITDSGSIYVQSDGEHLGFLPRKFQVLPGAIDIIS

Gene Information

Entrez Gene ID
819217
Gene Name
sphingoid long-chain bases kinase 2
Gene Symbol
AT2G46090
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:TAIR C mitochondrion
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0017050 TAS:TAIR F D-erythro-sphingosine kinase activity
GO:0003951 IEA:InterPro F NAD+ kinase activity
GO:0004143 IEA:InterPro F diacylglycerol kinase activity
GO:0006671 IMP:TAIR P phytosphingosine metabolic process
GO:0007205 IEA:InterPro P protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0009409 IMP:TAIR P response to cold

Domain Information

InterPro Annotations

Accession Description
IPR016064 ATP-NAD kinase-like domain
IPR001206 Diacylglycerol kinase, catalytic domain
IPR005218 Diacylglycerol/lipid kinase

UniProt Annotations

Entry Information

Gene Name
sphingoid long-chain bases kinase 2
Protein Entry
LCKB2_ARATH
UniProt ID
O82359
Species
Arabidopsis

Comments

Comment Type Description
Function Involved in the production of sphingoid long-chain base (LCB). Is required for the cold-induced accumulation of phytosphingosine-phosphate, the regulation of the cold-responsive MPK6 and reduction of root growth at moderate low temperature. {ECO:0000269|PubMed:22236066}.
Sequence Caution Sequence=AAK62459.1; Type=Frameshift; Positions=212; Evidence={ECO:0000305}; Sequence=AAL66946.1; Type=Frameshift; Positions=212; Evidence={ECO:0000305};
Similarity Contains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}.
Subcellular Location Mitochondrion {ECO:0000269|PubMed:18643979}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011301 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18406971 RefSeq NP_566064 364 sphingoid long-chain bases kinase 2

Identical Sequences to LMP011301 proteins

Reference Database Accession Length Protein Name
GI:18406971 GenBank AEC10642.1 364 sphingoid long-chain bases kinase 2 [Arabidopsis thaliana]
GI:18406971 gnl TIGR 364 expressed protein [Arabidopsis thaliana]
GI:18406971 SwissProt O82359.1 364 RecName: Full=Sphingoid long-chain bases kinase 2, mitochondrial; Short=AtLCBK2; Short=LCB kinase 2; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP011301 proteins

Reference Database Accession Length Protein Name
GI:18406971 GenBank EFH56474.1 366 diacylglycerol kinase family protein, partial [Arabidopsis lyrata subsp. lyrata]
GI:18406971 GenBank EOA28876.1 364 hypothetical protein CARUB_v10025121mg [Capsella rubella]
GI:18406971 GenBank KFK37387.1 369 hypothetical protein AALP_AA4G250900 [Arabis alpina]
GI:18406971 RefSeq XP_002880215.1 366 diacylglycerol kinase family protein, partial [Arabidopsis lyrata subsp. lyrata]
GI:18406971 RefSeq XP_006295978.1 364 hypothetical protein CARUB_v10025121mg [Capsella rubella]
GI:18406971 RefSeq XP_010506608.1 366 PREDICTED: sphingoid long-chain bases kinase 2, mitochondrial [Camelina sativa]