Gene/Proteome Database (LMPD)

LMPD ID
LMP011226
Gene ID
842284
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
pyruvate dehydrogenase complex E1 alpha subunit
Gene Symbol
E1 ALPHA
Synonyms
AT-E1 ALPHA; E1 ALPHA; pyruvate dehydrogenase complex E1 alpha subunit; PYRUVATE DEHYDROGENASE E1 ALPHA SUBUNIT
Alternate Names
pyruvate dehydrogenase complex E1 alpha subunit
Chromosome
1
EC Number
1.2.4.1
Summary
encodes the e1 alpha subunit of the pyruvate dehydrogenase complex (PDC)
Orthologs
View orthologs and multiple alignments for E1 ALPHA

Proteins

pyruvate dehydrogenase complex E1 alpha subunit
Refseq ID NP_176198
Protein GI 15218940
UniProt ID P52901
mRNA ID NM_104682
Length 389
RefSeq Status REVIEWED
MALSRLSSRSNIITRPFSAAFSRLISTDTTPITIETSLPFTAHLCDPPSRSVESSSQELLDFFRTMALMRRMEIAADSLYKAKLIRGFCHLYDGQEAVAIGMEAAITKKDAIITAYRDHCIFLGRGGSLHEVFSELMGRQAGCSKGKGGSMHFYKKESSFYGGHGIVGAQVPLGCGIAFAQKYNKEEAVTFALYGDGAANQGQLFEALNISALWDLPAILVCENNHYGMGTAEWRAAKSPSYYKRGDYVPGLKVDGMDAFAVKQACKFAKQHALEKGPIILEMDTYRYHGHSMSDPGSTYRTRDEISGVRQERDPIERIKKLVLSHDLATEKELKDMEKEIRKEVDDAIAKAKDCPMPEPSELFTNVYVKGFGTESFGPDRKEVKASLP

Gene Information

Entrez Gene ID
842284
Gene Name
pyruvate dehydrogenase complex E1 alpha subunit
Gene Symbol
E1 ALPHA
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:TAIR C cytosol
GO:0005739 IDA:TAIR C mitochondrion
GO:0005634 IDA:TAIR C nucleus
GO:0004739 IEA:UniProtKB-EC F pyruvate dehydrogenase (acetyl-transferring) activity
GO:0006096 IEA:UniProtKB-KW P glycolytic process
GO:0046686 IEP:TAIR P response to cadmium ion

KEGG Pathway Links

KEGG Pathway ID Description
ath01200 Carbon metabolism
ath00020 Citrate cycle (TCA cycle)
ath00010 Glycolysis / Gluconeogenesis
ath_M00307 Pyruvate oxidation, pyruvate => acetyl-CoA

Domain Information

InterPro Annotations

Accession Description
IPR001017 Dehydrogenase, E1 component
IPR017597 Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y
IPR029061 Thiamin diphosphate-binding fold

UniProt Annotations

Entry Information

Gene Name
pyruvate dehydrogenase complex E1 alpha subunit
Protein Entry
ODPA1_ARATH
UniProt ID
P52901
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
Cofactor Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
Enzyme Regulation E1 activity is regulated by phosphorylation (inactivation) and dephosphorylation (activation) of the alpha subunit. {ECO:0000250}.
Function The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).
Subcellular Location Mitochondrion matrix {ECO:0000269|PubMed:14671022}.
Subunit Tetramer of 2 alpha and 2 beta subunits. {ECO:0000250}.
Tissue Specificity Expressed in roots, rosettes and flowers. {ECO:0000269|PubMed:7590338}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011226 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15218940 RefSeq NP_176198 389 pyruvate dehydrogenase complex E1 alpha subunit

Identical Sequences to LMP011226 proteins

Reference Database Accession Length Protein Name
GI:15218940 GenBank ACX16347.1 389 Sequence 43439 from patent US 7569389
GI:15218940 GenBank ACX16549.1 389 Sequence 43714 from patent US 7569389
GI:15218940 GenBank ACX18175.1 389 Sequence 45915 from patent US 7569389
GI:15218940 GenBank ACX19640.1 389 Sequence 47891 from patent US 7569389
GI:15218940 GenBank AEE33638.1 389 pyruvate dehydrogenase complex E1 alpha subunit [Arabidopsis thaliana]
GI:15218940 SwissProt P52901.2 389 RecName: Full=Pyruvate dehydrogenase E1 component subunit alpha-1, mitochondrial; Short=PDHE1-A; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP011226 proteins

Reference Database Accession Length Protein Name
GI:15218940 GenBank AAA86507.1 389 pyruvate dehydrogenase E1 alpha subunit [Arabidopsis thaliana]
GI:15218940 GenBank AAK26016.1 389 putative pyruvate dehydrogenase e1 alpha subunit [Arabidopsis thaliana]
GI:15218940 GenBank ACX16346.1 413 Sequence 43438 from patent US 7569389
GI:15218940 GenBank ACX16548.1 413 Sequence 43713 from patent US 7569389
GI:15218940 GenBank ACX19639.1 409 Sequence 47890 from patent US 7569389
GI:15218940 GenBank ACX21390.1 389 Sequence 50256 from patent US 7569389