Gene/Proteome Database (LMPD)

LMPD ID
LMP011169
Gene ID
843440
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
1-phosphatidylinositol-4-phosphate 5-kinase
Gene Symbol
FAB1C
Synonyms
F23N20.21; FAB1C; FORMS APLOID AND BINUCLEATE CELLS 1C
Alternate Names
1-phosphatidylinositol-4-phosphate 5-kinase
Chromosome
1
EC Number
2.7.1.150
Summary
Encodes a protein that is predicted to act as a phosphatidylinositol-3P 5-kinase, but, because it lacks a FYVE domain, it is unlikely to be efficiently targeted to membranes containing the proposed phosphatidylinositol-3P substrate. Therefore, its molecular function remains unknown.
Orthologs
View orthologs and multiple alignments for FAB1C

Proteins

1-phosphatidylinositol-4-phosphate 5-kinase
Refseq ID NP_177257
Protein GI 42563125
UniProt ID Q9SSJ8
mRNA ID NM_105770
Length 1648
RefSeq Status REVIEWED
MGIPDGSLLDLIDKVRSWITSDSSDSLFLLSSSKQDFGIMPIVSKMCHDCGTKVEQGYCCLSCGSCWCKSCSDTEESKMKLCRECDAEVRELRVKSYDKVHPRDSPDPPSSLATESESLASSLEIRDCRNMASIRCYPSRGEEEEARYCGKQLLSPSSDNYQDSSDIESGSVSARHELFSCKSSAGSSPHDSPLRNNFSPLGRFVQHAKDLRSPTVCSFDNHQEQLLADNLVKPGQGVLEQEDHEEEEDKLQQPLDFENNGRIWYPPPPEDENDDAESNYFHYDDEDDDIGDSATEFSLSSSFSSHIPTKEKLGENSNEPLRTVVHDHFRALVAELLRGEELSPSDDGSAGEWLDIVTALAWQAANFVKPDTRAGGSMDPGNYVKIKCVASGNQNESILIRGIVCSKNITHKRMISQYKNPRVMLLAGSLEYQRVAGQLASFNTLLQQENEHMKAIIAKIESLRPNVLLVEKSASSYAQQYLLEKEISLVLNVKRSLLDRIARCTGAVLCPSLDSISTARLGHCELFRTERVLEQHEAGNQSNRKPSRTLMYFEGCPRRLGCTVVLRGSCREELKKVKHVIQYAVFAAYHLSLETSFLADEGASLPKIRLKQPGMVRTASQRRIIDEGISLITQSPTETDSQALLETAAHEDEHTAPMPEHEVCESLCEDFDPTQIFPPSSEVETEQSDTLNGDFANNLVTRSYSSNQLNDLHEPTLCLSSEIPETPTQQPSGEEDNGRGEEENQLVNPQDLPQHESFYEDDVSSEYFSAADSHQSILVSFSSRCVLKESVCERSRLLRIKFYGSFDKPLGRYLKDDLFDKTSSCRSCKELVDAHVLCYSHQNGNLTINVRRLPSMKLPGEQDGKIWMWHRCLRCAHVDGVPPATRRVVMSDAAWGLSFGKFLELSFSNHATANRVASCGHSLQRDCLRFYGFGNMVAFFRYSPINILTVLLPPSMLEFNSHPQQEWIRTEAAELVGKMRTMYTEISDMLNRMEEKSSLLEPEQSEACDLHSRIIGLIDQLVKEKDEYDDALQPIFEENLQIQGSLDILELNRLRRALMIGAHAWDHQLYLLNSQLKKASVFKTGDDNAPRNPEMHDPPKIDRRMQEGSDERDEQSHTDSEANGDNKDPENIPSPGTSLSERIDSAWLGSFQNLEKAETIAETEGFSAVNSSLRRLARPIRVQSFDSAIRFQERIQKGLPPSSLYLSTLRSFHASGEYRNMVRDPVSNVMRTYSQMLPLEVQKLDLIVGSAPTYISSASQMADGARMLIPQRGLNDIVVPVYDDDPASVVSYAINSKEYKEWIVNKGLASSSSSSNLNNRESEPSAFSTWRSLSMDVDYIQHAVYGSSQDDRKSPHLTISFSDRASSSSTATEGKVKFSVTCYFATQFDTLRKTCCPSEVDFVRSLSRCQRWSAQGGKSNVYFAKSLDERFIIKQVVKTELDSFEDFAPEYFKYLKESLSSGSPTCLAKILGIYQVSIKHPKGGKETKMDLMVMENLFYNRRISRIYDLKGSARSRYNPNTSGADKVLLDMNLLETLRTEPIFLGSKAKRSLERAIWNDTNFLASVDVMDYSLLVGFDEERKELVLGIIDFMRQYTWDKHLETWVKASGILGGPKNASPTIVSPKQYKRRFRKAMTTYFLTVPEPWTS

Gene Information

Entrez Gene ID
843440
Gene Name
1-phosphatidylinositol-4-phosphate 5-kinase
Gene Symbol
FAB1C
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000285 IDA:TAIR F 1-phosphatidylinositol-3-phosphate 5-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0044267 IEA:InterPro P cellular protein metabolic process
GO:0046854 IDA:GOC P phosphatidylinositol phosphorylation
GO:0090332 IMP:TAIR P stomatal closure

KEGG Pathway Links

KEGG Pathway ID Description
ath00562 Inositol phosphate metabolism
ath04145 Phagosome

REACTOME Pathway Links

REACTOME Pathway ID Description
6254338 Synthesis of PIPs at the early endosome membrane
6254335 Synthesis of PIPs at the late endosome membrane

Domain Information

InterPro Annotations

Accession Description
IPR002423 Chaperonin Cpn60/TCP-1
IPR027409 GroEL-like apical domain
IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core

UniProt Annotations

Entry Information

Gene Name
1-phosphatidylinositol-4-phosphate 5-kinase
Protein Entry
FAB1C_ARATH
UniProt ID
Q9SSJ8
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol 3- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate.
Caution Lacks the FYVE domain, necessary to efficiently target the protein to membranes containing the phosphatidylinositol-3P substrate. Therefore, its molecular function remains unknown. {ECO:0000305}.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
Function The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate (By similarity). {ECO:0000250}.
Sequence Caution Sequence=AAL38344.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Contains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Subunit Component of the PI(3,5)P2 regulatory complex at least composed of ATG18, SAC/FIG4, FAB1 and VAC14. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011169 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
42563125 RefSeq NP_177257 1648 1-phosphatidylinositol-4-phosphate 5-kinase

Identical Sequences to LMP011169 proteins

Reference Database Accession Length Protein Name
GI:42563125 GenBank AAD55502.1 1648 Unknown protein [Arabidopsis thaliana]
GI:42563125 GenBank AEE35150.1 1648 1-phosphatidylinositol-4-phosphate 5-kinase [Arabidopsis thaliana]
GI:42563125 SwissProt Q9SSJ8.1 1648 RecName: Full=Putative 1-phosphatidylinositol-3-phosphate 5-kinase FAB1C; Short=Phosphatidylinositol 3-phosphate 5-kinase; AltName: Full=Phosphatidylinositol 3-phosphate 5-kinase type III; Short=PIPkin-III; Short=Type III PIP kinase; AltName: Full=Protein FORMS APLOID AND BINUCLEATE CELLS 1C [Arabidopsis thaliana]

Related Sequences to LMP011169 proteins

Reference Database Accession Length Protein Name
GI:42563125 GenBank EFH63602.1 1653 predicted protein [Arabidopsis lyrata subsp. lyrata]
GI:42563125 GenBank EOA33480.1 1651 hypothetical protein CARUB_v10019654mg [Capsella rubella]
GI:42563125 GenBank EOA33481.1 1651 hypothetical protein CARUB_v10019654mg [Capsella rubella]
GI:42563125 RefSeq XP_002887343.1 1653 predicted protein [Arabidopsis lyrata subsp. lyrata]
GI:42563125 RefSeq XP_006300582.1 1651 hypothetical protein CARUB_v10019654mg [Capsella rubella]
GI:42563125 RefSeq XP_006300583.1 1651 hypothetical protein CARUB_v10019654mg [Capsella rubella]