Gene/Proteome Database (LMPD)

LMPD ID
LMP011122
Gene ID
840067
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
protein LUTEIN DEFICIENT 5
Gene Symbol
CYP97A3
Synonyms
cytochrome P450; F5M6.19; F5M6_19; family 97; LUT5; LUTEIN DEFICIENT 5; polypeptide 3; subfamily A
Alternate Names
protein LUTEIN DEFICIENT 5
Chromosome
1
EC Number
1.14.-.-
Summary
Encodes a protein with β-ring carotenoid hydroxylase activity.
Orthologs
View orthologs and multiple alignments for CYP97A3

Proteins

protein LUTEIN DEFICIENT 5
Refseq ID NP_564384
Protein GI 18398119
UniProt ID Q93VK5
mRNA ID NM_102914
Length 595
RefSeq Status REVIEWED
MAMAFPLSYTPTITVKPVTYSRRSNFVVFSSSSNGRDPLEENSVPNGVKSLEKLQEEKRRAELSARIASGAFTVRKSSFPSTVKNGLSKIGIPSNVLDFMFDWTGSDQDYPKVPEAKGSIQAVRNEAFFIPLYELFLTYGGIFRLTFGPKSFLIVSDPSIAKHILKDNAKAYSKGILAEILDFVMGKGLIPADGEIWRRRRRAIVPALHQKYVAAMISLFGEASDRLCQKLDAAALKGEEVEMESLFSRLTLDIIGKAVFNYDFDSLTNDTGVIEAVYTVLREAEDRSVSPIPVWDIPIWKDISPRQRKVATSLKLINDTLDDLIATCKRMVEEEELQFHEEYMNERDPSILHFLLASGDDVSSKQLRDDLMTMLIAGHETSAAVLTWTFYLLTTEPSVVAKLQEEVDSVIGDRFPTIQDMKKLKYTTRVMNESLRLYPQPPVLIRRSIDNDILGEYPIKRGEDIFISVWNLHRSPLHWDDAEKFNPERWPLDGPNPNETNQNFSYLPFGGGPRKCIGDMFASFENVVAIAMLIRRFNFQIAPGAPPVKMTTGATIHTTEGLKLTVTKRTKPLDIPSVPILPMDTSRDEVSSALS

Gene Information

Entrez Gene ID
840067
Gene Name
protein LUTEIN DEFICIENT 5
Gene Symbol
CYP97A3
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IDA:TAIR C chloroplast
GO:0009941 IDA:TAIR C chloroplast envelope
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0010291 IMP:TAIR F carotene beta-ring hydroxylase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0016705 IEA:InterPro F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016117 IMP:TAIR P carotenoid biosynthetic process
GO:0016123 IGI:TAIR P xanthophyll biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath_M00372 Abscisic acid biosynthesis, beta-carotene => abscisic acid
ath00906 Carotenoid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
6253810 Eicosanoids
6254116 Miscellaneous substrates

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
protein LUTEIN DEFICIENT 5
Protein Entry
LUT5_ARATH
UniProt ID
Q93VK5
Species
Arabidopsis

Comments

Comment Type Description
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Disruption Phenotype Accumulation of alpha-carotene and alpha- cryptoxanthin. Triple mutant CYP97A3-BCH1-BCH2 has a highly retarded growth. {ECO:0000269|PubMed:16492736, ECO:0000269|PubMed:16890225}.
Function Heme-containing cytochrome P450 involved in the biosynthesis of xanthophylls. Specific for beta-ring hydroxylation of alpha- and beta-carotene. Has also a low activity toward the epsilon-rings of alpha-carotene. The beta-ring of alpha-carotene is the preferred substrate in planta. {ECO:0000269|PubMed:16492736, ECO:0000269|PubMed:16890225, ECO:0000269|PubMed:19147649}.
Miscellaneous Alpha-carotene is incorporated into photosystems in lut5 mutants.
Sequence Caution Sequence=AAG50718.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Plastid, chloroplast membrane {ECO:0000269|PubMed:20061580}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011122 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18398119 RefSeq NP_564384 595 protein LUTEIN DEFICIENT 5

Identical Sequences to LMP011122 proteins

Reference Database Accession Length Protein Name
GI:18398119 GenBank AAL08302.1 595 At1g31800/68069_m00159 [Arabidopsis thaliana]
GI:18398119 GenBank AAL25587.1 595 At1g31800/68069_m00159 [Arabidopsis thaliana]
GI:18398119 GenBank AAM98281.1 595 At1g31800/68069_m00159 [Arabidopsis thaliana]
GI:18398119 GenBank ACW94566.1 595 Sequence 13821 from patent US 7569389
GI:18398119 GenBank AEE31394.1 595 protein LUTEIN DEFICIENT 5 [Arabidopsis thaliana]
GI:18398119 SwissProt Q93VK5.1 595 RecName: Full=Protein LUTEIN DEFICIENT 5, chloroplastic; AltName: Full=Cytochrome P450 97A3; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP011122 proteins

Reference Database Accession Length Protein Name
GI:18398119 GenBank AAG50718.1 593 cytochrome P450, putative [Arabidopsis thaliana]
GI:18398119 GenBank ACW94567.1 593 Sequence 13822 from patent US 7569389
GI:18398119 GenBank EOA37709.1 594 hypothetical protein CARUB_v10012441mg [Capsella rubella]
GI:18398119 RefSeq XP_006304811.1 594 hypothetical protein CARUB_v10012441mg [Capsella rubella]
GI:18398119 RefSeq XP_010499724.1 595 PREDICTED: protein LUTEIN DEFICIENT 5, chloroplastic-like [Camelina sativa]
GI:18398119 RefSeq XP_010461000.1 595 PREDICTED: protein LUTEIN DEFICIENT 5, chloroplastic [Camelina sativa]