Gene/Proteome Database (LMPD)

LMPD ID
LMP011097
Gene ID
834026
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
farnesyltransferase subunit beta
Gene Symbol
ERA1
Synonyms
ARABIDOPSIS THALIANA FARNESYL TRANSFERASE BETA SUBUNIT; ATFTB; ENHANCED RESPONSE TO ABA 1; ERA1; FARNESYL TRANSFERASE BETA SUBUNIT; MSN9.180; MSN9_180; WIG; WIGGUM
Alternate Names
farnesyltransferase subunit beta
Chromosome
5
EC Number
2.5.1.58

Proteins

farnesyltransferase subunit beta
Refseq ID NP_198844
Protein GI 15242635
UniProt ID Q38920
mRNA ID NM_123392
Length 482
RefSeq Status REVIEWED
MPVVTRLIRLKCVGLRLDRSGLNRRICHGGHGESTRRRVMEELSSLTVSQREQFLVENDVFGIYNYFDASDVSTQKYMMEIQRDKQLDYLMKGLRQLGPQFSSLDANRPWLCYWILHSIALLGETVDDELESNAIDFLGRCQGSEGGYGGGPGQLPHLATTYAAVNALVTLGGDKALSSINREKMSCFLRRMKDTSGGFRMHDMGEMDVRACYTAISVASILNIMDDELTQGLGDYILSCQTYEGGIGGEPGSEAHGGYTYCGLAAMILINEVDRLNLDSLMNWAVHRQGVEMGFQGRTNKLVDGCYTFWQAAPCVLLQRLYSTNDHDVHGSSHISEGTNEEHHAHDEDDLEDSDDDDDSDEDNDEDSVNGHRIHHTSTYINRRMQLVFDSLGLQRYVLLCSKIPDGGFRDKPRKPRDFYHTCYCLSGLSVAQHAWLKDEDTPPLTRDIMGGYSNLLEPVQLLHNIVMDQYNEAIEFFFKAA

Gene Information

Entrez Gene ID
834026
Gene Name
farnesyltransferase subunit beta
Gene Symbol
ERA1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005965 ISS:UniProtKB C protein farnesyltransferase complex
GO:0004311 ISS:TAIR F farnesyltranstransferase activity
GO:0004660 ISS:UniProtKB F protein farnesyltransferase activity
GO:0008270 ISS:UniProtKB F zinc ion binding
GO:0009788 IMP:TAIR P negative regulation of abscisic acid-activated signaling pathway
GO:0018343 ISS:UniProtKB P protein farnesylation
GO:0018342 IMP:TAIR P protein prenylation
GO:0042127 IEA:InterPro P regulation of cell proliferation
GO:0009934 IMP:TAIR P regulation of meristem structural organization
GO:0009737 IMP:TAIR P response to abscisic acid
GO:0009414 IMP:TAIR P response to water deprivation

KEGG Pathway Links

KEGG Pathway ID Description
ath00900 Terpenoid backbone biosynthesis
ko00900 Terpenoid backbone biosynthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5120 geranylgeranyldiphosphate biosynthesis
PWY-5863 superpathway of phylloquinol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001330 Prenyltransferase/squalene oxidase
IPR026872 Protein farnesyltransferase subunit beta
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

UniProt Annotations

Entry Information

Gene Name
farnesyltransferase subunit beta
Protein Entry
FNTB_ARATH
UniProt ID
Q38920
Species
Arabidopsis

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=5.4 uM for CVIM substrate {ECO:0000269|PubMed:20565889}; KM=5.5 uM for CVIQ substrate {ECO:0000269|PubMed:20565889}; KM=6.9 uM for CVII substrate {ECO:0000269|PubMed:20565889}; KM=7.0 uM for CVIL substrate {ECO:0000269|PubMed:20565889}; Note=Kcat is 49.1 h(-1), 28.8 h(-1), 12.8 h(-1) and 3.7 h(-1) for CVIQ, CVIM, CVII and CVIL substrates, respectively.;
Catalytic Activity Farnesyl diphosphate + protein-cysteine = S- farnesyl protein + diphosphate.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:20565889}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:20565889};
Disruption Phenotype Plants show an increase in floral organ number, particularly in the sepals and petals, correlating with an increase in the width of young floral meristems. {ECO:0000269|PubMed:10840062}.
Function Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys- aliphatic-aliphatic-X (CaaX). The beta subunit is responsible for peptide-binding. {ECO:0000269|PubMed:20565889}.
Interaction Q9LX33:FTA; NbExp=4; IntAct=EBI-1553332, EBI-1553317;
Sequence Caution Sequence=BAB10909.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the protein prenyltransferase subunit beta family. {ECO:0000305}.
Similarity Contains 5 PFTB repeats. {ECO:0000305}.
Subunit Heterodimer of FTA and FTB (farnesyltransferase). Heterodimer of an alpha and a beta subunit. {ECO:0000269|PubMed:20565889}.

Identical and Related Proteins

Unique RefSeq proteins for LMP011097 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15242635 RefSeq NP_198844 482 farnesyltransferase subunit beta

Identical Sequences to LMP011097 proteins

Reference Database Accession Length Protein Name
GI:15242635 GenBank ABW47651.1 482 Sequence 87 from patent US 7262338
GI:15242635 GenBank ABW47673.1 482 Sequence 177 from patent US 7262338
GI:15242635 GenBank AEQ82901.1 482 Sequence 81 from patent US 8030470
GI:15242635 GenBank AFX49829.1 482 Sequence 51662 from patent US 8299318
GI:15242635 gnl TAIR 482 farnesyltransferase subunit beta [Arabidopsis thaliana]
GI:15242635 SwissProt Q38920.3 482 RecName: Full=Protein farnesyltransferase subunit beta; Short=FTase-beta; AltName: Full=CAAX farnesyltransferase subunit beta; AltName: Full=Enhanced response to abscisic acid 1; AltName: Full=Ras proteins prenyltransferase subunit beta [Arabidopsis thaliana]

Related Sequences to LMP011097 proteins

Reference Database Accession Length Protein Name
GI:15242635 DBBJ BAB10909.1 404 farnesyltransferase beta subunit [Arabidopsis thaliana]
GI:15242635 GenBank AAA86658.1 403 beta subunit of protein farnesyl transferase, partial [Arabidopsis thaliana]
GI:15242635 GenBank AAA87585.1 404 protein farnesyl transferase beta subunit, partial [Arabidopsis thaliana]
GI:15242635 GenBank AAM20474.1 443 beta subunit of protein farnesyl transferase ERA1 [Arabidopsis thaliana]
GI:15242635 GenBank ABN37891.1 404 Sequence 80 from patent US 7172881
GI:15242635 GenBank AEQ82900.1 404 Sequence 80 from patent US 8030470