Gene/Proteome Database (LMPD)

LMPD ID
LMP010988
Gene ID
830881
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
myo-inositol-1-phosphate synthase
Gene Symbol
MIPS3
Synonyms
ATMIPS3; MIPS3; myo-inositol-1-phosphate synthase 3; MYO-INOSITOL-1-PHOSTPATE SYNTHASE 3; T31P16.160; T31P16_160
Alternate Names
myo-inositol-1-phosphate synthase
Chromosome
5
EC Number
5.5.1.4

Proteins

myo-inositol-1-phosphate synthase
Refseq ID NP_196579
Protein GI 15238080
UniProt ID Q9LX12
mRNA ID NM_121055
Length 510
RefSeq Status REVIEWED
MFIESFKVESPNVKYTENEIHSVYDYQTTELVHENKNGAFQWTVKPKTVKYEFKTDTHVPKLGVMLVGWGGNNGSTLTAGVIANREGISWATKEKVQQANYFGSLTQASSIRVGSFNGEEIYAPFKSLLPMVNPEEIVFGGWDISDMNLADAMARAKVLDIDLQKQMRPFMEHMVPLPGIFDPDFIAANQGSRANHVIKGTKKQQLEQVIKDIREFKEKNKVDKVVVLWTANTERYSNVVVGLNDTTENLMSSLDKDEAEISPSTLYAIACVLENVPFINGSPQNTFVPGLIELAIKRNCLIGGDDFKSGQTKMKSVLVDFLVGAGIKPTSIVSYNHLGNNDGMNLSAPQTFRSKEISKSNVVDDMVGSNGILYEPGEHPDHVVVIKYVPCVGDSKRAMDEYTSEIFMGGKNTIVMHNTCEDSLLAAPIILDLVLLAELTTRIQFMSENEGKFHSFHPVATLLSYLSKAPLVPPGTPVVNALSKQRAMLENVLRACVGLAPENNMILEYK

Gene Information

Entrez Gene ID
830881
Gene Name
myo-inositol-1-phosphate synthase
Gene Symbol
MIPS3
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:TAIR C cytoplasm
GO:0004512 IGI:TAIR F inositol-3-phosphate synthase activity
GO:0009793 IGI:TAIR P embryo development ending in seed dormancy
GO:0006021 IEA:UniProtKB-UniPathway P inositol biosynthetic process
GO:0008654 IEA:UniProtKB-KW P phospholipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath00562 Inositol phosphate metabolism
ath01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
6254349 Synthesis of IP2, IP, and Ins in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR002587 Myo-inositol-1-phosphate synthase
IPR013021 Myo-inositol-1-phosphate synthase, GAPDH-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
myo-inositol-1-phosphate synthase
Protein Entry
INO3_ARATH
UniProt ID
Q9LX12
Species
Arabidopsis

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=0.31 mM for D-glucose 6-phosphate {ECO:0000269|PubMed:20215587}; KM=0.13 uM for NAD(+) {ECO:0000269|PubMed:20215587}; Note=kcat is 5.2 min(-1) for D-glucose 6-phosphate. kcat is 4.8 min(-1) for NAD(+).;
Catalytic Activity D-glucose 6-phosphate = 1D-myo-inositol 3- phosphate. {ECO:0000269|PubMed:20215587}.
Cofactor Name=NAD(+); Xref=ChEBI:CHEBI:57540;
Disruption Phenotype Lethal when homozygous. {ECO:0000269|PubMed:19812700}.
Function Involved in myo-inositol synthesis. {ECO:0000269|PubMed:20215587}.
Pathway Polyol metabolism; myo-inositol biosynthesis; myo- inositol from D-glucose 6-phosphate: step 1/2.
Similarity Belongs to the myo-inositol 1-phosphate synthase family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:18603618, ECO:0000269|PubMed:20215587}.
Tissue Specificity Expressed in siliques, leaves, roots, seed endosperm, but not in embryos. Highest expression in roots. Confined to vascular tissue and hydathodes of leaves. {ECO:0000269|PubMed:18603618, ECO:0000269|PubMed:20215587}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010988 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15238080 RefSeq NP_196579 510 myo-inositol-1-phosphate synthase

Identical Sequences to LMP010988 proteins

Reference Database Accession Length Protein Name
GI:15238080 EMBL CAB92058.1 510 myo-inositol-1-phosphate synthase-like protein [Arabidopsis thaliana]
GI:15238080 GenBank AAL38856.1 510 putative myo-inositol-1-phosphate synthase [Arabidopsis thaliana]
GI:15238080 GenBank AAM20204.1 510 putative myo-inositol-1-phosphate synthase [Arabidopsis thaliana]
GI:15238080 gnl TAIR 510 myo-inositol-1-phosphate synthase [Arabidopsis thaliana]
GI:15238080 SwissProt Q9LX12.1 510 RecName: Full=Probable inositol 3-phosphate synthase isozyme 3; Short=AtIPS3; Short=MIP synthase 3; AltName: Full=Myo-inositol 1-phosphate synthase 3; Short=AtMIPS 3; Short=MI-1-P synthase 3 [Arabidopsis thaliana]

Related Sequences to LMP010988 proteins

Reference Database Accession Length Protein Name
GI:15238080 GenBank ACK44508.1 517 AT5G10170-like protein [Arabidopsis arenosa]
GI:15238080 GenBank EFH49702.1 510 hypothetical protein ARALYDRAFT_487844 [Arabidopsis lyrata subsp. lyrata]
GI:15238080 GenBank EOA20439.1 510 hypothetical protein CARUB_v10000750mg [Capsella rubella]
GI:15238080 RefSeq XP_002873443.1 510 hypothetical protein ARALYDRAFT_487844 [Arabidopsis lyrata subsp. lyrata]
GI:15238080 RefSeq XP_006287541.1 510 hypothetical protein CARUB_v10000750mg [Capsella rubella]
GI:15238080 RefSeq XP_010422882.1 510 PREDICTED: probable inositol 3-phosphate synthase isozyme 3 [Camelina sativa]