Gene/Proteome Database (LMPD)

LMPD ID
LMP010892
Gene ID
817046
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phospholipid hydroperoxide glutathione peroxidase 1
Gene Symbol
GPX1
Synonyms
ATGPX1; F13D4.40; F13D4_40; glutathione peroxidase 1; GLUTATHIONE PEROXIDASE 1; GPX1
Alternate Names
phospholipid hydroperoxide glutathione peroxidase 1
Chromosome
2
EC Number
1.11.1.12
Summary
Encodes glutathione peroxidase.
Orthologs
View orthologs and multiple alignments for GPX1

Proteins

phospholipid hydroperoxide glutathione peroxidase 1
Refseq ID NP_180080
Protein GI 15224678
UniProt ID P52032
mRNA ID NM_128065
Length 236
RefSeq Status REVIEWED
MVSMTTSSSSYGTFSTVVNSSRPNSSATFLVPSLKFSTGISNFANLSNGFSLKSPINPGFLFKSRPFTVQARAAAEKTVHDFTVKDIDGKDVALNKFKGKVMLIVNVASRCGLTSSNYSELSHLYEKYKTQGFEILAFPCNQFGFQEPGSNSEIKQFACTRFKAEFPIFDKVDVNGPSTAPIYEFLKSNAGGFLGGLIKWNFEKFLIDKKGKVVERYPPTTSPFQIEKDIQKLLAA

Gene Information

Entrez Gene ID
817046
Gene Name
phospholipid hydroperoxide glutathione peroxidase 1
Gene Symbol
GPX1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IDA:TAIR C chloroplast
GO:0009941 IDA:TAIR C chloroplast envelope
GO:0009570 IDA:TAIR C chloroplast stroma
GO:0009535 IDA:TAIR C chloroplast thylakoid membrane
GO:0004602 IEA:InterPro F glutathione peroxidase activity
GO:0047066 IEA:UniProtKB-EC F phospholipid-hydroperoxide glutathione peroxidase activity
GO:0006979 IEA:InterPro P response to oxidative stress

KEGG Pathway Links

KEGG Pathway ID Description
ath00590 Arachidonic acid metabolism
ath00480 Glutathione metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6254372 Synthesis of 12-eicosatetraenoic acid derivatives
6254371 Synthesis of 5-eicosatetraenoic acids

Domain Information

InterPro Annotations

Accession Description
IPR000889 Glutathione peroxidase
IPR029759 Glutathione peroxidase active site
IPR029760 Glutathione peroxidase conserved site
IPR012336 Thioredoxin-like fold

UniProt Annotations

Entry Information

Gene Name
phospholipid hydroperoxide glutathione peroxidase 1
Protein Entry
GPX1_ARATH
UniProt ID
P52032
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity 2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O.
Function Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. {ECO:0000250}.
Induction By salt stress, osmotic stress, metals and heat treatment. Up-regulated by abscisic acid (ABA) and auxin. {ECO:0000269|PubMed:14617062}.
Similarity Belongs to the glutathione peroxidase family. {ECO:0000305}.
Subcellular Location Plastid, chloroplast stroma {ECO:0000269|PubMed:12766230}.
Tissue Specificity Expressed in leaves, stems, flowers, green siliques and seeds. {ECO:0000269|PubMed:14617062}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010892 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15224678 RefSeq NP_180080 236 phospholipid hydroperoxide glutathione peroxidase 1

Identical Sequences to LMP010892 proteins

Reference Database Accession Length Protein Name
GI:15224678 GenBank AAK59657.1 236 putative glutathione peroxidase [Arabidopsis thaliana]
GI:15224678 GenBank AAL34198.1 236 putative glutathione peroxidase [Arabidopsis thaliana]
GI:15224678 GenBank ADT60630.1 236 Sequence 2150 from patent US 7847156
GI:15224678 GenBank AEC07655.1 236 phospholipid hydroperoxide glutathione peroxidase 1 [Arabidopsis thaliana]
GI:15224678 GenBank AGD03034.1 236 Sequence 490 from patent US 8343764
GI:15224678 SwissProt P52032.2 236 RecName: Full=Phospholipid hydroperoxide glutathione peroxidase 1, chloroplastic; Short=PHGPx; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP010892 proteins

Reference Database Accession Length Protein Name
GI:15224678 EMBL CAA61965.1 242 glutathione peroxidase [Arabidopsis thaliana]
GI:15224678 GenBank EFH55083.1 236 ATGPX1 [Arabidopsis lyrata subsp. lyrata]
GI:15224678 GenBank AGD12218.1 242 Sequence 9674 from patent US 8343764
GI:15224678 GenBank EOA27818.1 236 hypothetical protein CARUB_v10023973mg [Capsella rubella]
GI:15224678 RefSeq XP_002878824.1 236 ATGPX1 [Arabidopsis lyrata subsp. lyrata]
GI:15224678 RefSeq XP_006294920.1 236 hypothetical protein CARUB_v10023973mg [Capsella rubella]