Gene/Proteome Database (LMPD)
LMPD ID
LMP010877
Gene ID
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phospholipase D gamma 2
Gene Symbol
Synonyms
AT4G11835; phospholipase D gamma 2; PLDGAMMA2; T26M18.40; T26M18_40
Alternate Names
phospholipase D gamma 2
Chromosome
4
EC Number
3.1.4.4
Summary
Encodes one of three phospholipase D enzymes of the gamma class.
Orthologs
Proteins
| phospholipase D gamma 2 | |
|---|---|
| Refseq ID | NP_192920 |
| Protein GI | 42566498 |
| UniProt ID | Q9T051 |
| mRNA ID | NM_117252 |
| Length | 856 |
| RefSeq Status | REVIEWED |
| MSMGGGSNHEFGQWLDQQLVPLATSSGSLMVELLHGNLDIWVKEAKHLPNMICYRNKLVGGISFSELGRRIRKVDGEKSSKFTSDPYVTVSISGAVIGRTFVISNSENPVWMQHFDVPVAHSAAEVHFVVKDNDPIGSKIIGVVGIPTKQLCSGNRIEGLFPILNSSGKPCRKGAMLSLSIQYTPMERMRLYQKGVGSGVECVGVPGTYFPLRKGGRVTLYQDAHVDDGTLPSVHLDGGIQYRHGKCWEDMADAIRRARRLIYITGWSVFHPVRLVRRNNDPTEGTLGELLKVKSQEGVRVLVLVWDDPTSMSFPGFSTKGLMNTSDEETRRFFKHSSVQVLLCPRYGGKGHSFIKKSEVETIYTHHQKTMIVDAEAAQNRRKIVAFVGGLDLCNGRFDTPKHSLFGTLKTLHKDDFHNPNFVTTEDVGPREPWHDLHSKIDGPAAYDVLANFEERWMASKPRGIGKGRTSFDDSLLRINRIPDIMGLSEASSANDNDPESWHVQVFRSIDSTSVKGFPKDPEEATGRNLLCGKNILIDMSIHAAYVKAIRSAQHFIYIENQYFLGSSFNWDSNKDLGANNLIPMEIALKIANKIRARENFAAYIVIPMWPEGAPTSKPIQRILYWQHKTMQMMYQTIYKALLEVGLDGQLEPQDFLNFFCLGNREVGTREVPDGTVNVYNCPRKPPQPNAAQVQALKSRRFMIYVHSKGMVVDDEFVLIGSANINQRSLEGTRDTEIAMGGYQPHHSWAKKGSRPRGQIFGYRMSLWAEHLGFLEQEFEEPENMECVRRVRQLSELNWGQYAAEEVTEMSGHLLKYPVQVDKTGKVSSLPGCETFPDLGGKIIGSFLTLQENLTI | |
| phospholipase D gamma 2 | |
|---|---|
| Refseq ID | NP_849539 |
| Protein GI | 30681908 |
| UniProt ID | Q9T051 |
| mRNA ID | NM_179208 |
| Length | 824 |
| RefSeq Status | REVIEWED |
| MSMGGGSNHEFGQWLDQQLVPLATSSGSLMVELLHGRRIRKVDGEKSSKFTSDPYVTVSISGAVIGRTFVISNSENPVWMQHFDVPVAHSAAEVHFVVKDNDPIGSKIIGVVGIPTKQLCSGNRIEGLFPILNSSGKPCRKGAMLSLSIQYTPMERMRLYQKGVGSGVECVGVPGTYFPLRKGGRVTLYQDAHVDDGTLPSVHLDGGIQYRHGKCWEDMADAIRRARRLIYITGWSVFHPVRLVRRNNDPTEGTLGELLKVKSQEGVRVLVLVWDDPTSMSFPGFSTKGLMNTSDEETRRFFKHSSVQVLLCPRYGGKGHSFIKKSEVETIYTHHQKTMIVDAEAAQNRRKIVAFVGGLDLCNGRFDTPKHSLFGTLKTLHKDDFHNPNFVTTEDVGPREPWHDLHSKIDGPAAYDVLANFEERWMASKPRGIGKGRTSFDDSLLRINRIPDIMGLSEASSANDNDPESWHVQVFRSIDSTSVKGFPKDPEEATGRNLLCGKNILIDMSIHAAYVKAIRSAQHFIYIENQYFLGSSFNWDSNKDLGANNLIPMEIALKIANKIRARENFAAYIVIPMWPEGAPTSKPIQRILYWQHKTMQMMYQTIYKALLEVGLDGQLEPQDFLNFFCLGNREVGTREVPDGTVNVYNCPRKPPQPNAAQVQALKSRRFMIYVHSKGMVVDDEFVLIGSANINQRSLEGTRDTEIAMGGYQPHHSWAKKGSRPRGQIFGYRMSLWAEHLGFLEQEFEEPENMECVRRVRQLSELNWGQYAAEEVTEMSGHLLKYPVQVDKTGKVSSLPGCETFPDLGGKIIGSFLTLQENLTI | |
Gene Information
Entrez Gene ID
Gene Name
phospholipase D gamma 2
Gene Symbol
Species
Arabidopsis thaliana
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0009507 | IDA:TAIR | C | chloroplast |
| GO:0022626 | IDA:TAIR | C | cytosolic ribosome |
| GO:0016020 | IEA:UniProtKB-KW | C | membrane |
| GO:0070290 | IEA:UniProtKB-EC | F | N-acylphosphatidylethanolamine-specific phospholipase D activity |
| GO:0005509 | IEA:InterPro | F | calcium ion binding |
| GO:0004630 | IEA:UniProtKB-EC | F | phospholipase D activity |
| GO:0016042 | IEA:UniProtKB-KW | P | lipid catabolic process |
| GO:0006643 | IMP:TAIR | P | membrane lipid metabolic process |
| GO:0046470 | IEA:InterPro | P | phosphatidylcholine metabolic process |
| GO:0006979 | IMP:TAIR | P | response to oxidative stress |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ath04144 | Endocytosis |
| ath00565 | Ether lipid metabolism |
| ath00564 | Glycerophospholipid metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 6254320 | Synthesis of PG |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PLDgamma2a; IsoId=Q9T051-1; Sequence=Displayed; Name=2; Synonyms=PLDDgamma2b; IsoId=Q9T051-2; Sequence=VSP_026065; |
| Catalytic Activity | A phosphatidylcholine + H(2)O = choline + a phosphatidate. |
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Ca(2+). Requires micromolar level (PIP2-dependent).; |
| Domain | C2 domain is a calcium-binding fold, and the binding promotes the protein association with membranes. In PLD gamma, all the calcium-coordinating acidic amino acids are conserved. |
| Enzyme Regulation | Inhibited by neomycin. |
| Function | Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond. Plays an important role in various cellular processes, including phytohormone action, vesicular trafficking, secretion, cytoskeletal arrangement, meiosis, tumor promotion, pathogenesis, membrane deterioration and senescence. Can use phosphatidylserine but prefers ethanolamine-containing lipids as substrates. |
| Induction | Activated by wounding, heavy metal, methyl salicylate, osmotic and salt stresses. |
| Similarity | Belongs to the phospholipase D family. C2-PLD subfamily. {ECO:0000305}. |
| Similarity | Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}. |
| Similarity | Contains 2 PLD phosphodiesterase domains. {ECO:0000255|PROSITE-ProRule:PRU00153}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:10198096}. Membrane {ECO:0000269|PubMed:10198096}; Peripheral membrane protein {ECO:0000269|PubMed:10198096}. Note=Found mainly associated with intracellular membranes but also with mitochondrial membranes, nuclei and clathrin-coated vesicles. Not found in chloroplast. |
| Tissue Specificity | Highly expressed in roots and flowers, moderately in stems, leaves and seedlings and low in siliques. Not detected in seeds. {ECO:0000269|PubMed:17098468}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP010877 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 42566498 | RefSeq | NP_192920 | 856 | phospholipase D gamma 2 |
| 30681908 | RefSeq | NP_849539 | 824 | phospholipase D gamma 2 |
Identical Sequences to LMP010877 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:42566498 | EMBL | CAB44321.1 | 856 | putative phospholipase D-gamma [Arabidopsis thaliana] |
| GI:42566498 | EMBL | CAB78226.1 | 856 | putative phospholipase D-gamma [Arabidopsis thaliana] |
| GI:30681908 | GenBank | AAD38519.2 | 824 | phospholipase Dgamma2b [Arabidopsis thaliana] |
| GI:42566498 | GenBank | ABG88077.1 | 856 | phospholipase D gamma 2a [Arabidopsis thaliana] |
| GI:30681908 | GenBank | AEE83054.1 | 824 | phospholipase D gamma 2 [Arabidopsis thaliana] |
| GI:42566498 | GenBank | AEE83055.1 | 856 | phospholipase D gamma 2 [Arabidopsis thaliana] |
| GI:42566498 | SwissProt | Q9T051.3 | 856 | RecName: Full=Phospholipase D gamma 2; Short=AtPLDgamma2; Short=PLD gamma 2 [Arabidopsis thaliana] |
Related Sequences to LMP010877 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:30681908 | EMBL | CAB44321.1 | 856 | putative phospholipase D-gamma [Arabidopsis thaliana] |
| GI:42566498 | EMBL | CAB44322.1 | 866 | putative phospholipase D-gamma [Arabidopsis thaliana] |
| GI:30681908 | EMBL | CAB78226.1 | 856 | putative phospholipase D-gamma [Arabidopsis thaliana] |
| GI:42566498 | EMBL | CAB78227.1 | 866 | putative phospholipase D-gamma [Arabidopsis thaliana] |
| GI:42566498 | GenBank | AAD38519.2 | 824 | phospholipase Dgamma2b [Arabidopsis thaliana] |
| GI:30681908 | GenBank | ABG88077.1 | 856 | phospholipase D gamma 2a [Arabidopsis thaliana] |
| GI:42566498 | GenBank | AEE83054.1 | 824 | phospholipase D gamma 2 [Arabidopsis thaliana] |
| GI:30681908 | GenBank | AEE83055.1 | 856 | phospholipase D gamma 2 [Arabidopsis thaliana] |
| GI:42566498 | RefSeq | NP_849539.1 | 824 | phospholipase D gamma 2 [Arabidopsis thaliana] |
| GI:30681908 | RefSeq | NP_192920.3 | 856 | phospholipase D gamma 2 [Arabidopsis thaliana] |
| GI:42566498 | SwissProt | Q9T052.1 | 866 | RecName: Full=Phospholipase D gamma 3; Short=AtPLDgamma3; Short=PLD gamma 3 [Arabidopsis thaliana] |
| GI:30681908 | SwissProt | Q9T051.3 | 856 | RecName: Full=Phospholipase D gamma 2; Short=AtPLDgamma2; Short=PLD gamma 2 [Arabidopsis thaliana] |