Gene/Proteome Database (LMPD)

LMPD ID
LMP010873
Gene ID
826673
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phospholipase D beta 2
Gene Symbol
PLDBETA2
Synonyms
F5I10.13; phospholipase D beta 2; PLDBETA2
Alternate Names
phospholipase D beta 2
Chromosome
4
EC Number
3.1.4.4
Summary
member of C2-PLD subfamily
Orthologs
View orthologs and multiple alignments for PLDBETA2

Proteins

phospholipase D beta 2
Refseq ID NP_567160
Protein GI 18411265
UniProt ID O23078
mRNA ID NM_116245
Length 927
RefSeq Status REVIEWED
MENYGWNYPYYPYRPPRPNPPYPAPPHHHGSMSHSGPLDHHHPPMSYYASFDYQHQPPPPYPPVSYYASFSSHSDLSYSGRLDSSGHGFTSTASPHSPGMHIVPFGKASLKVLLLHGNLDIWVSCANNLPNLDLFHKTLGVVFGGMTNMIEGQLSKKITSDPYVSISVAGAVIGRTYVISNSENPVWQQHFYVPVAHHAAEVHFVVKDSDAVGSQLIGIVTIPVEQIYSGARIEGTYSIRDSNGKPCKPGATLSLSIQYTSMNKLSVYHSGVGAGPYYQGVPGTYFPLREGGSVTLYQDAHVPEGMLPGIKLGNGMCYEHGKCWHDMFHAICQARRLIYITGWSVWHNVRLVRDKEDPSSECRLGELLRSKSQEGVRVLLLVWDDPTSQNILGYMTDGVMGTHDEETRRFFKDSSVQVLLCPRNAGKRHSWVKQREVGTIYTHHQKNLIVDADAGGNRRKIVAFVGGLDLCDGRYDTPQHPLFRTLQTDHNGDYHNPTFTGNVSGCPREPWHDLHSKIDGPAAYDVLTNFEERWLKAAKPHRINKLKTSYDDALLRIDRIPDILRVLDAPTVSANDPEAWHVQIFRSIDSNSVKGFPKDPKYATSKNLVCGKNVLIDMSIHTAYVKAIRAAQHFIYIENQYFIGSSYDWNAHKDIGANNLIPMEIALKIADKIRAKERFAAYIVIPMWPEGVPTGAATQRILYWQHKTMQMMYGTIYNALVEAGLEDEYSPQDYLNFFCLGNREMVNGNNESGTGSASNENTPQGLCRKSRRFMIYVHSKGMVVDDEYVVIGSANINQRSMEGTRDTEIAMGAYQPQHTWARRQSGPRGQIYGYRMSLWAEHMALLDDCFVEPESLGCVRKVRTVAEENWEQFRSEEVSEMRGHLMKYPVEVDRKGKVRPLPGSEEFPDVGGNVVGSFLAIQENLTI

Gene Information

Entrez Gene ID
826673
Gene Name
phospholipase D beta 2
Gene Symbol
PLDBETA2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0070290 IEA:UniProtKB-EC F N-acylphosphatidylethanolamine-specific phospholipase D activity
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004630 IDA:TAIR F phospholipase D activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0046470 IEA:InterPro P phosphatidylcholine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath04144 Endocytosis
ath00565 Ether lipid metabolism
ath00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6254320 Synthesis of PG

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR015679 Phospholipase D family
IPR024632 Phospholipase D, C-terminal
IPR011402 Phospholipase D, plant
IPR001736 Phospholipase D/Transphosphatidylase

UniProt Annotations

Entry Information

Gene Name
phospholipase D beta 2
Protein Entry
PLDB2_ARATH
UniProt ID
O23078
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity A phosphatidylcholine + H(2)O = choline + a phosphatidate.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Ca(2+). Requires micromolar level (PIP2-dependent).;
Domain C2 domain is a calcium-binding fold, and the binding promotes the protein association with membranes. In PLD beta, all the calcium-coordinating acidic amino acids are conserved.
Enzyme Regulation Inhibited by neomycin.
Function Hydrolyzes glycerol-phospholipids at the terminal phosphodiesteric bond. Plays an important role in various cellular processes, including phytohormone action, vesicular trafficking, secretion, cytoskeletal arrangement, meiosis, tumor promotion, pathogenesis, membrane deterioration and senescence. Can use phosphatidylserine or N-acylphosphatidylethanolamine as substrates.
Induction Activated by wounding, methyl jasmonate, heavy metal, osmotic and salt stresses.
Sequence Caution Sequence=AAB62845.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAF02803.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAB80782.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the phospholipase D family. C2-PLD subfamily. {ECO:0000305}.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 2 PLD phosphodiesterase domains. {ECO:0000255|PROSITE-ProRule:PRU00153}.
Subcellular Location Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity Expressed in stems, and to a lower amount in leaves, flowers and siliques.

Identical and Related Proteins

Unique RefSeq proteins for LMP010873 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18411265 RefSeq NP_567160 927 phospholipase D beta 2

Identical Sequences to LMP010873 proteins

Reference Database Accession Length Protein Name
GI:18411265 GenBank AEE81845.1 927 phospholipase D beta 2 [Arabidopsis thaliana]
GI:18411265 SwissProt O23078.3 927 RecName: Full=Phospholipase D beta 2; Short=AtPLDbeta2; Short=PLD beta 2; AltName: Full=PLDdelta1 [Arabidopsis thaliana]

Related Sequences to LMP010873 proteins

Reference Database Accession Length Protein Name
GI:18411265 GenBank EFH49219.1 987 PLDBETA2 [Arabidopsis lyrata subsp. lyrata]
GI:18411265 GenBank KFK30609.1 1079 hypothetical protein AALP_AA6G003800 [Arabis alpina]
GI:18411265 RefSeq XP_002872960.1 987 PLDBETA2 [Arabidopsis lyrata subsp. lyrata]
GI:18411265 RefSeq XP_010426771.1 1018 PREDICTED: phospholipase D beta 2-like [Camelina sativa]
GI:18411265 RefSeq XP_010419560.1 1022 PREDICTED: phospholipase D beta 2-like [Camelina sativa]
GI:18411265 RefSeq XP_010496903.1 828 PREDICTED: phospholipase D beta 2 isoform X3 [Camelina sativa]