Gene/Proteome Database (LMPD)

LMPD ID
LMP010850
Gene ID
818602
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phosphoinositide phospholipase C 6
Gene Symbol
AT2G40116
Alternate Names
phosphoinositide phospholipase C 6
Chromosome
2
EC Number
3.1.4.11

Proteins

phosphoinositide phospholipase C 6
Refseq ID NP_850327
Protein GI 42570393
UniProt ID Q8GV43
mRNA ID NM_179996
Length 613
RefSeq Status REVIEWED
MGKEKKTESYNNDSGSYNYRMFKFYNRKFKINEVTPTDDVRDAFCQFAVGGGGGGTDGDSSDGDGSTGVMGAEQLCSFLDDHGESTTVAEAQRLIDEVIRRRHHVTRFTRHGLDLDDFFNFLFYDDLNPPITPHVHQDMTAPLSHYFIYTGHNSYLTGNQLSSDCSEVPVIKALQRGVRVIELDLWPNSTGTDINVLHGRTLTTPVPLMKCLKSIRDYAFSSSPYPVIITLEDHLTPDLQAKVAEMATQIFGQMLYYPESDSLLEFPSPASLLHRIIISTKPPKEYLESRNPIVKQKDNNVSPSSEDETPRTEEIQTLESMLFDQDFESKSDSDQEDEEASEDQKPAYKRLITIHAGKPKGTVKEEMKVVVDKVRRLSLSEQELDRTCSSNSQDVVRFTQRNLLRIYPKGTRFNSSNYKPLIGWTHGAQMIAFNMQGYGKSLWLMHGMFRANGGCGYVKKPNFLMKKGFHDEVFDPRKKLPVKETLKVKVYMGDGWRMDFSHTHFDAYSPPDFYTKMFIVGVPADNAKKKTKIIEDNWYPIWDEEFSFPLTVPELALLRIEVREYDMSEKDDFGGQTCLPVAELRPGIRSVPLYDKKGEKMKSVRLLMRFIFE

Gene Information

Entrez Gene ID
818602
Gene Name
phosphoinositide phospholipase C 6
Gene Symbol
AT2G40116
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004435 IEA:UniProtKB-EC F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00562 Inositol phosphate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6254172 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
6253932 GPVI-mediated activation cascade
6254346 Signaling by FGFR1 fusion mutants

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like

UniProt Annotations

Entry Information

Gene Name
phosphoinositide phospholipase C 6
Protein Entry
PLCD6_ARATH
UniProt ID
Q8GV43
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. {ECO:0000250}.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
Tissue Specificity Expressed in leaves, flowers and siliques, but not in roots. {ECO:0000269|Ref.6}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010850 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
42570393 RefSeq NP_850327 613 phosphoinositide phospholipase C 6

Identical Sequences to LMP010850 proteins

Reference Database Accession Length Protein Name
GI:42570393 GenBank AEC09783.1 613 phosphoinositide phospholipase C 6 [Arabidopsis thaliana]
GI:42570393 SwissProt Q8GV43.2 613 RecName: Full=Phosphoinositide phospholipase C 6; AltName: Full=Phosphoinositide phospholipase PLC6; Short=AtPLC6; Short=AtPLC8; Short=PI-PLC6 [Arabidopsis thaliana]

Related Sequences to LMP010850 proteins

Reference Database Accession Length Protein Name
GI:42570393 GenBank ACX04359.1 602 Sequence 27155 from patent US 7569389
GI:42570393 GenBank EFH56105.1 618 phosphoinositide-specific phospholipase C family protein [Arabidopsis lyrata subsp. lyrata]
GI:42570393 GenBank EOA28382.1 617 hypothetical protein CARUB_v10024587mg [Capsella rubella]
GI:42570393 RefSeq XP_002879846.1 618 phosphoinositide-specific phospholipase C family protein [Arabidopsis lyrata subsp. lyrata]
GI:42570393 RefSeq XP_006295484.1 617 hypothetical protein CARUB_v10024587mg [Capsella rubella]
GI:42570393 RefSeq XP_010517422.1 614 PREDICTED: phosphoinositide phospholipase C 6 [Camelina sativa]