LIPID MAPS

LMPD ID

LMP010833

Gene ID

821324

Species

Arabidopsis thaliana (Arabidopsis)

Gene Name

phosphoethanolamine N-methyltransferase 1

Gene Symbol

XPL1

Synonyms

AT3G17990; N-METHYLTRANSFERASE 1; NMT1; PEAMT; S-ADENOSYL-L-METHIONINE:PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE; S-ADENOSYLMETHIONINE:PHOSPHO-ETHANOLAMINE; XIPOTL 1; XPL1

Alternate Names

phosphoethanolamine N-methyltransferase 1

Chromosome

3

EC Number

2.1.1.103

Summary

Arabidopsis thaliana N-methyltransferase-like protein mRNA. Reduce transmission through pollen.

Orthologs

View orthologs and multiple alignments for XPL1

phosphoethanolamine N-methyltransferase 1
Refseq ID	NP_188427
Protein GI	30684743
UniProt ID	Q9FR44
mRNA ID	NM_112681
Length	491
RefSeq Status	REVIEWED
MAASYEEERDIQKNYWIEHSADLTVEAMMLDSRASDLDKEERPEVLSLLPPYEGKSVLELGAGIGRFTGELAQKAGELIALDFIDNVIKKNESINGHYKNVKFMCADVTSPDLKITDGSLDLIFSNWLLMYLSDKEVELLAERMVGWIKVGGYIFFRESCFHQSGDSKRKSNPTHYREPRFYSKVFQECQTRDAAGNSFELSMIGCKCIGAYVKNKKNQNQICWIWQKVSSENDRGFQRFLDNVQYKSSGILRYERVFGQGFVSTGGLETTKEFVEKMNLKPGQKVLDVGCGIGGGDFYMAEKFDVHVVGIDLSVNMISFALERAIGLSCSVEFEVADCTTKHYPDNSFDVIYSRDTILHIQDKPALFRTFFKWLKPGGKVLISDYCRSPKTPSAEFSEYIKQRGYDLHDVQAYGQMLKDAGFTDVIAEDRTDQFMQVLKRELDRVEKEKEKFISDFSKEDYDDIVGGWKSKLERCASDEQKWGLFIANKN

Entrez Gene ID

821324

Gene Name

phosphoethanolamine N-methyltransferase 1

Gene Symbol

XPL1

Species

Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID	Source	Type	Description
GO:0005737	ISS:TAIR	C	cytoplasm
GO:0005829	IDA:TAIR	C	cytosol
GO:0008168	ISS:TAIR	F	methyltransferase activity
GO:0000234	IGI:TAIR	F	phosphoethanolamine N-methyltransferase activity
GO:0042425	IMP:TAIR	P	choline biosynthetic process
GO:0006656	IGI:TAIR	P	phosphatidylcholine biosynthetic process
GO:0009555	IMP:TAIR	P	pollen development
GO:0009860	IMP:TAIR	P	pollen tube growth
GO:0010183	IMP:TAIR	P	pollen tube guidance
GO:0048528	IMP:TAIR	P	post-embryonic root development
GO:0009826	IMP:TAIR	P	unidimensional cell growth

KEGG Pathway Links

KEGG Pathway ID	Description
ath00564	Glycerophospholipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID	Description
PWY4FS-3	phosphatidylcholine biosynthesis III
PWY4FS-4	phosphatidylcholine biosynthesis IV
PWY4FS-5	superpathway of phosphatidylcholine biosynthesis

InterPro Annotations

Accession	Description
IPR013216	Methyltransferase type 11
IPR025771	Phosphoethanolamine N-methyltransferase
IPR029063	S-adenosyl-L-methionine-dependent methyltransferase

Entry Information

Gene Name

phosphoethanolamine N-methyltransferase 1

Protein Entry

PEAM1_ARATH

UniProt ID

Q9FR44

Species

Arabidopsis

Comments

Comment Type	Description
Catalytic Activity	S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate. {ECO:0000255\|PROSITE-ProRule:PRU00915}.
Disruption Phenotype	Altered root development due to defect in primary root elongation and root epidermal cell development. {ECO:0000269\|PubMed:15295103}.
Function	Catalyzes N-methylation of phosphoethanolamine, phosphomonomethylethanolamine and phosphodimethylethanolamine, the three methylation steps required to convert phosphoethanolamine to phosphocholine. Required for root system development and epidermal cell integrity through its role in choline and phospholipid metabolism. {ECO:0000269\|PubMed:15295103}.
Pathway	Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from phosphoethanolamine: step 1/1.
Sequence Caution	Sequence=BAB02720.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity	Belongs to the class I-like SAM-binding methyltransferase superfamily. PEAMT family. {ECO:0000255\|PROSITE- ProRule:PRU00915}.
Subcellular Location	Cytoplasm {ECO:0000305}.

Unique RefSeq proteins for LMP010833 (as displayed in Record Overview)

Protein GI	Database	Accession	Length	Protein Name
30684743	RefSeq	NP_188427	491	phosphoethanolamine N-methyltransferase 1

Identical Sequences to LMP010833 proteins

Reference	Database	Accession	Length	Protein Name
GI:30684743	GenBank	AAG41121.1	491	SAM:phospho-ethanolamine N-methyltransferase [Arabidopsis thaliana]
GI:30684743	GenBank	AAK32886.1	491	AT3g18000/MEB5_22 [Arabidopsis thaliana]
GI:30684743	GenBank	AAL25589.1	491	AT3g18000/MEB5_22 [Arabidopsis thaliana]
GI:30684743	GenBank	AAM10282.1	491	AT3g18000/MEB5_22 [Arabidopsis thaliana]
GI:30684743	GenBank	AEE76033.1	491	phosphoethanolamine N-methyltransferase 1 [Arabidopsis thaliana]
GI:30684743	SwissProt	Q9FR44.1	491	RecName: Full=Phosphoethanolamine N-methyltransferase 1; Short=AtNMT1; Short=PEAMT 1; AltName: Full=Protein XIPOTL 1 [Arabidopsis thaliana]

Related Sequences to LMP010833 proteins

Reference	Database	Accession	Length	Protein Name
GI:30684743	DBBJ	BAB02720.1	498	methyl transferase-like protein [Arabidopsis thaliana]
GI:30684743	GenBank	AAM13092.1	491	unknown protein [Arabidopsis thaliana]
GI:30684743	GenBank	EFH59359.1	491	N-methyltransferase 1 [Arabidopsis lyrata subsp. lyrata]
GI:30684743	GenBank	EOA30415.1	491	hypothetical protein CARUB_v10013541mg [Capsella rubella]
GI:30684743	RefSeq	XP_002883100.1	491	N-methyltransferase 1 [Arabidopsis lyrata subsp. lyrata]
GI:30684743	RefSeq	XP_006297517.1	491	hypothetical protein CARUB_v10013541mg [Capsella rubella]