Gene/Proteome Database (LMPD)

LMPD ID
LMP010785
Gene ID
842344
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
phosphatidylinositol 3-kinase VPS34
Gene Symbol
VPS34
Synonyms
ATVPS34; F8A5.4; F8A5_4; PHOSPATIDYLINOSITOL 3-KINASE; PHOSPHATIDYLINOSITOL 3-KINASE; PI3K; vacuolar protein sorting 34; VPS34
Alternate Names
phosphatidylinositol 3-kinase VPS34
Chromosome
1
EC Number
2.7.1.137
Summary
Encodes a phosphatidylinositol 3-kinase that is expressed in most plant tissues. Defects in VPS34 affect a number of cellular processes. Loss of function mutations are not transmitted through the male gametophyte due to defects in microgametogenesis therefore it is difficult to assess the effects of loss of VPS34 function in the whole plant. Involved in salt-stress responses.
Orthologs
View orthologs and multiple alignments for VPS34

Proteins

phosphatidylinositol 3-kinase VPS34
Refseq ID NP_176251
Protein GI 15219743
UniProt ID P42339
mRNA ID NM_104735
Length 814
RefSeq Status REVIEWED
MGANEFRFFLSCDINSPVTFRIEKLDGNLPVKKSSDSGVVSIAEEKKPELYIECALYIDGAPFGLPMRTRLKTTGPPYCWNELITLSSKYRDLTAHSQLAITVWDVSCGKTEGLIGGATVLLFNSKMQMKSGKQKLRLWQGKEADGSFPTSTPGKVPRHERGELERLEKLMNKYERGQIQSIDWLDRLMLKSLDTIKEQESTKHGSSHLFVVIDFCSFEHRVVFQESGANLFITAPIGSTNEFVTVWDTELGKTNPSENKQLKLARSLDRGIIDRDLKPSNIERKSIQRVLKYPPTRTLSGDERQLLWKFRFSLMSEKRALTKFLRCVEWSDVQEAKQAIQLMYKWEMIDVCDALELLSPLFESEEVRAYAVSVLERADDEELQCYLLQLVQALRFERSDRSCLSQFLVQRALQNIELASFLRWYVAVELHDHVYAKRFYSTYELLEENIIKLPPGVNGEDGYQLWQSLVRQTELTAQLCSITREVRNVRGNTQKKIEKLRQLLGGLLSELTYFEEPIRSPLTPNVLIKGIVAGESSLFKSALHPLRLTFRTPEEGGSCKLIFKKGDDLRQDQLVVQMVWLMDRLLKLENLDLCLTPYKVLATGHDEGMLEFIPSRSLAQILSEHRSITSYLQKFHPDEHAPFGITATCLDTFIKSCAGYSVITYILGIGDRHLDNLLLTDDGRLFHVDFAFILGRDPKPFPPPMKLCKEMVEAMGGAESQYYTRFKSYCCEAYNILRKSSNLILNLFHLMAGSTIPDIASDPEKGILKLQEKFRLDMDDEACIHFFQDLINESVSALFPQMVETIHRWAQYWR

Gene Information

Entrez Gene ID
842344
Gene Name
phosphatidylinositol 3-kinase VPS34
Gene Symbol
VPS34
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016303 IEA:UniProtKB-EC F 1-phosphatidylinositol-3-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0006897 IDA:TAIR P endocytosis
GO:0055046 IMP:TAIR P microgametogenesis
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling
GO:0072593 IMP:TAIR P reactive oxygen species metabolic process
GO:0009651 IMP:TAIR P response to salt stress

KEGG Pathway Links

KEGG Pathway ID Description
ath00562 Inositol phosphate metabolism
ath04145 Phagosome
ath04140 Regulation of autophagy

REACTOME Pathway Links

REACTOME Pathway ID Description
6254335 Synthesis of PIPs at the late endosome membrane

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR008290 Phosphatidylinositol 3-kinase, Vps34 type
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 3-kinase VPS34
Protein Entry
PI3K_ARATH
UniProt ID
P42339
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
Similarity Belongs to the PI3/PI4-kinase family. {ECO:0000255|PROSITE-ProRule:PRU00880}.
Similarity Contains 1 C2 PI3K-type domain. {ECO:0000255|PROSITE- ProRule:PRU00880}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
Similarity Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010785 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15219743 RefSeq NP_176251 814 phosphatidylinositol 3-kinase VPS34

Identical Sequences to LMP010785 proteins

Reference Database Accession Length Protein Name
GI:15219743 GenBank AAB71971.1 814 Phosphatidylinositol 3-kinase [Arabidopsis thaliana]
GI:15219743 GenBank AAN41278.1 814 putative phosphatidylinositol 3-kinase [Arabidopsis thaliana]
GI:15219743 GenBank AEE33693.1 814 phosphatidylinositol 3-kinase VPS34 [Arabidopsis thaliana]
GI:15219743 SwissProt P42339.2 814 RecName: Full=Phosphatidylinositol 3-kinase VPS34; AltName: Full=PI3-kinase VPS34; Short=AtVPS34; Short=PI3K VPS34; AltName: Full=PtdIns-3-kinase VSP34 [Arabidopsis thaliana]

Related Sequences to LMP010785 proteins

Reference Database Accession Length Protein Name
GI:15219743 GenBank AAA83427.1 814 phosphatidylinositol 3-kinase [Arabidopsis thaliana]
GI:15219743 GenBank EFH62873.1 813 ATVPS34 [Arabidopsis lyrata subsp. lyrata]
GI:15219743 GenBank EOA33952.1 813 hypothetical protein CARUB_v10021447mg [Capsella rubella]
GI:15219743 RefSeq XP_002886614.1 813 ATVPS34 [Arabidopsis lyrata subsp. lyrata]
GI:15219743 RefSeq XP_010510944.1 813 PREDICTED: phosphatidylinositol 3-kinase VPS34-like isoform X1 [Camelina sativa]
GI:15219743 RefSeq XP_010417982.1 813 PREDICTED: phosphatidylinositol 3-kinase VPS34 isoform X1 [Camelina sativa]