Gene/Proteome Database (LMPD)

LMPD ID
LMP010762
Gene ID
819602
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
Peroxisome biogenesis protein 12
Gene Symbol
PEX12
Synonyms
ABERRANT PEROXISOME MORPHOLOGY 4; APM4; ATPEX12; peroxin-12; PEROXIN-12; PEX12; T27C4.11; T27C4_11
Alternate Names
Peroxisome biogenesis protein 12
Chromosome
3
Summary
RING finger protein involved in peroxisome biogenesis. Also involved in peroxisomal import of nitric oxide synthase.
Orthologs
View orthologs and multiple alignments for PEX12

Proteins

Peroxisome biogenesis protein 12
Refseq ID NP_187096
Protein GI 42563493
UniProt ID Q9M841
mRNA ID NM_111317
Length 393
RefSeq Status REVIEWED
MLFQVGGEGTRPTFFEMAAAQQLPASLRAALTYSLGVFALRRSFLHKILDYEDEFFAALMLILEGHSLRTTDGSFAESLYGLRRKSARLRLRKDSARKDSSEEVQHSGLEKRQRILSVVFLVVLPYFKSKLHAIYNKEREARLRESLWGAEDQGFDEADFFTGDDSIVSREPSGNEELSVRVQLATKIKKFIAVCYPWIHASSEGLSFTYQLLYLLDATGFYSLGLQALGIQVCRATGQELMDTSSRISKIRNHERERLRGPPWLKTVQGALLSCSYAVLDYAQTGLIAAVFIFKMMEWWYQSAEERLSAPTVYPPPPPPPAPKMAKEGIPLPPDRSLCALCLQKRANPSVVTVSGFVFCYSCVFKYVSKYKRCPVTLIPASVDQIRRLFQDT

Gene Information

Entrez Gene ID
819602
Gene Name
Peroxisome biogenesis protein 12
Gene Symbol
PEX12
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005779 IEA:InterPro C integral component of peroxisomal membrane
GO:0005778 IDA:TAIR C peroxisomal membrane
GO:0005777 IDA:TAIR C peroxisome
GO:0004842 IDA:TAIR F ubiquitin-protein transferase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0048598 IMP:TAIR P embryonic morphogenesis
GO:0006635 IMP:TAIR P fatty acid beta-oxidation
GO:0007031 IMP:TAIR P peroxisome organization
GO:0016558 IDA:TAIR P protein import into peroxisome matrix
GO:0006513 IDA:TAIR P protein monoubiquitination

KEGG Pathway Links

KEGG Pathway ID Description
ath04146 Peroxisome
ko04146 Peroxisome

Domain Information

InterPro Annotations

Accession Description
IPR017375 Peroxisome assembly protein 12
IPR006845 Pex, N-terminal
IPR001841 Zinc finger, RING-type
IPR013083 Zinc finger, RING/FYVE/PHD-type

UniProt Annotations

Entry Information

Gene Name
Peroxisome biogenesis protein 12
Protein Entry
PEX12_ARATH
UniProt ID
Q9M841
Species
Arabidopsis

Comments

Comment Type Description
Disruption Phenotype Embryo lethality at the heart stage. {ECO:0000269|PubMed:16113209}.
Function Required for peroxisome biogenesis and for PTS1- and PTS2-dependent protein import into peroxisomes. Essential for the peroxisomal targeting of PEX7. Required for the export/release of receptors on the peroxisome membrane. Acts as an E3 ubiquitin- protein ligase involved in monoubiquitination of PEX5. {ECO:0000269|PubMed:16113209, ECO:0000269|PubMed:16813573, ECO:0000269|PubMed:17478547, ECO:0000269|PubMed:19594707, ECO:0000269|PubMed:20679226, ECO:0000269|PubMed:23336935}.
Sequence Caution Sequence=AAF63777.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAC42305.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BX824646; Type=Frameshift; Positions=250; Evidence={ECO:0000305};
Similarity Belongs to the pex2/pex10/pex12 family. {ECO:0000305}.
Similarity Contains 1 RING-type zinc finger. {ECO:0000305}.
Subcellular Location Peroxisome membrane {ECO:0000305}; Multi- pass membrane protein {ECO:0000305}.
Subunit Interacts (via C-terminus) with PEX7. Interacts with DSK2a and DSK2b. {ECO:0000269|PubMed:19594707, ECO:0000269|PubMed:23336935}.
Tissue Specificity Expressed in young seedlings, roots, leaves, seeds and flowers. {ECO:0000269|PubMed:16113209}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010762 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
42563493 RefSeq NP_187096 393 Peroxisome biogenesis protein 12

Identical Sequences to LMP010762 proteins

Reference Database Accession Length Protein Name
GI:42563493 GenBank AEE74085.1 393 Peroxisome biogenesis protein 12 [Arabidopsis thaliana]
GI:42563493 SwissProt Q9M841.2 393 RecName: Full=Peroxisome biogenesis protein 12; AltName: Full=Peroxin-12; Short=AtPEX12; AltName: Full=Pex12p; AltName: Full=Protein ABERRANT PEROXISOME MORPHOLOGY 4 [Arabidopsis thaliana]

Related Sequences to LMP010762 proteins

Reference Database Accession Length Protein Name
GI:42563493 GenBank EFH58610.1 393 peroxin-12 [Arabidopsis lyrata subsp. lyrata]
GI:42563493 GenBank EOA30756.1 393 hypothetical protein CARUB_v10013898mg [Capsella rubella]
GI:42563493 RefSeq XP_002882351.1 393 peroxin-12 [Arabidopsis lyrata subsp. lyrata]
GI:42563493 RefSeq XP_006297858.1 393 hypothetical protein CARUB_v10013898mg [Capsella rubella]
GI:42563493 RefSeq XP_010415110.1 393 PREDICTED: peroxisome biogenesis protein 12-like [Camelina sativa]
GI:42563493 RefSeq XP_010485821.1 393 PREDICTED: LOW QUALITY PROTEIN: peroxisome biogenesis protein 12-like [Camelina sativa]