Gene/Proteome Database (LMPD)

LMPD ID
LMP010736
Gene ID
824660
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
patatin-like protein 6
Gene Symbol
PLA IIIA
Synonyms
patatin-like protein 6; PATATIN-LIKE PROTEIN 7; PLA IIIA; PLP7; T15C9.3
Alternate Names
patatin-like protein 6
Chromosome
3
EC Number
3.1.1.-

Proteins

patatin-like protein 6
Refseq ID NP_191055
Protein GI 15233136
UniProt ID Q9SV43
mRNA ID NM_115352
Length 488
RefSeq Status REVIEWED
MHRVRNKPVKSTATASVKHLIKQRGGDGATAASKSANDYNNNDSLLTDMQEPSIDTDKLSYEIFSILESKFLFGYDDSKPEPANSVVAGSIKNQRGKICILSIDGGGMRGILPGKALAYLEHALKSKSGDPNARIADYFDVAAGSGIGGIYTAMLFGSRDGNRPIFKADDTWQFLTRNAKGLYGGAGILKRVLRTGSGCCSGTAKLKKVMKESFSELTLKDTLKPVLIPCYDLKSSGPFLFSRADALETDGYDFRLSEVCRATWAEPGVFEPVEMKSVDGQTKCVAVGGGLAMSNPTAAAITHVLHNKQEFPFVRGVEDLLVLSLGMGQLLDVSYEYDRIIKWKAKHWARPAALISNDGAADTVDQAVAMAFGHCRSSNYVRIQANGSNLGPWSPNMDTDPSGSNVNMLMGVAEEMLKQKNVESVLFGGKRIDEQSNFEKLDWLAGELVLEHQRRNSRIAPTVAFKQSVHRADQKTSDKDIGVTARER

Gene Information

Entrez Gene ID
824660
Gene Name
patatin-like protein 6
Gene Symbol
PLA IIIA
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005886 IDA:TAIR C plasma membrane
GO:0047617 IDA:TAIR F acyl-CoA hydrolase activity
GO:0004620 IDA:TAIR F phospholipase activity
GO:0019374 IMP:TAIR P galactolipid metabolic process
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0006644 IMP:TAIR P phospholipid metabolic process
GO:0040008 IEA:UniProtKB-KW P regulation of growth
GO:0051707 IEP:TAIR P response to other organism

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR002641 Patatin/Phospholipase A2-related

UniProt Annotations

Entry Information

Gene Name
patatin-like protein 6
Protein Entry
PLP7_ARATH
UniProt ID
Q9SV43
Species
Arabidopsis

Comments

Comment Type Description
Caution Lacks the conserved Asp residue expected to act as the active site proton acceptor. {ECO:0000305}.
Disruption Phenotype Increased length of leaves, petioles, hypocotyls, primary roots and root hairs. Changes in lipid levels and composition. {ECO:0000269|PubMed:21447788}.
Domain The nitrogen atoms of the two glycine residues in the GGXR motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage. {ECO:0000250}.
Function Possesses non-specific lipolytic acyl hydrolase (LAH) activity. Catalyzes the hydrolysis of the galactolipids monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG), and the phoshpolipids phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylglycerol (PG), phosphatidic acid (PA), phosphatidylserine (PS). Favors the release of fatty acid at the sn-2 position for PC. Possesses acyl- CoA thioesterase activity. Negatively affects disease resistance to the necrotic fungal pathogen Botrytis cinerea and the avirulent bacteria Pseudomonas syringae by promoting cell death and reducing the efficiency of the hypersensitive response, respectively. However, PLP2 contributes to resistance to cucumber mosaic virus (CMV), an obligate parasite inducing hypersensitive response. May negatively regulate oxylipin production, possibly via participating in membrane repair that includes removal of oxidatively modified lipids. Enzymatic products of PLP2 may influence cellulose content and cell elongation. {ECO:0000269|PubMed:21447788}.
Induction By the fungal pathogen B.cinerea and an avirulent strain of P.syringae pv tomato. {ECO:0000269|PubMed:16297072, ECO:0000269|PubMed:21447788}.
Miscellaneous Plants over-expressing PLP7 have decreased cellulose content and mechanical strength. {ECO:0000305|PubMed:21447788}.
Similarity Belongs to the patatin family. {ECO:0000305}.
Similarity Contains 1 patatin domain. {ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000305|PubMed:21447788}; Peripheral membrane protein {ECO:0000305|PubMed:21447788}. Note=Associated with the plasma membrane.
Tissue Specificity Highly expressed in roots and at lower levels in leaves, stems, flowers and siliques. {ECO:0000269|PubMed:21447788}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010736 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15233136 RefSeq NP_191055 488 patatin-like protein 6

Identical Sequences to LMP010736 proteins

Reference Database Accession Length Protein Name
GI:15233136 EMBL CAW95288.1 488 unnamed protein product [Arabidopsis thaliana]
GI:15233136 EMBL CAX05737.1 488 unnamed protein product [Arabidopsis thaliana]
GI:15233136 EMBL CBD12782.1 488 unnamed protein product [Arabidopsis thaliana]
GI:15233136 EMBL CBC97027.1 488 unnamed protein product [Arabidopsis thaliana]
GI:15233136 GenBank ACW97920.1 488 Sequence 18370 from patent US 7569389
GI:15233136 GenBank AEE79317.1 488 patatin-like protein 6 [Arabidopsis thaliana]

Related Sequences to LMP010736 proteins

Reference Database Accession Length Protein Name
GI:15233136 EMBL CAX05733.1 440 unnamed protein product [Arabidopsis thaliana]
GI:15233136 EMBL CBC97019.1 440 unnamed protein product [Arabidopsis thaliana]
GI:15233136 GenBank ACW97921.1 440 Sequence 18371 from patent US 7569389
GI:15233136 GenBank ACW99803.1 440 Sequence 20941 from patent US 7569389
GI:15233136 GenBank EFH54266.1 504 hypothetical protein ARALYDRAFT_485912 [Arabidopsis lyrata subsp. lyrata]
GI:15233136 RefSeq XP_002878007.1 504 hypothetical protein ARALYDRAFT_485912 [Arabidopsis lyrata subsp. lyrata]