Gene/Proteome Database (LMPD)

LMPD ID
LMP010681
Gene ID
821243
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
non-specific phospholipase C4
Gene Symbol
NPC4
Synonyms
non-specific phospholipase C4; NPC4; T21P5.5; T21P5_5
Alternate Names
non-specific phospholipase C4
Chromosome
3
EC Number
3.1.4.3
Summary
PHOSPHOESTERASE FAMILY PROTEIN, NPC4 is significantly induced upon phosphate starvation and plays an important role in the supply of inorganic phosphate and diacylglycerol from membrane-phospholipids during phosphate deprivation.
Orthologs
View orthologs and multiple alignments for NPC4

Proteins

non-specific phospholipase C4
Refseq ID NP_566206
Protein GI 18396577
UniProt ID Q9SRQ7
mRNA ID NM_111224
Length 538
RefSeq Status REVIEWED
MIETTKGGSGSYPIKTIVVLVQENRSFDHTLGWFKELNREIDGVTKSDPKSNTVSSSDTNSLRVVFGDQSQYVNPDPGHSIQDIYEQVFGKPWDSGKPDPNPGHPNMSGFAQNAERNKKGMSSAVMNGFKPNALPVYKELVQNFAICDRWFASVPASTQPNRLYVHSATSHGATSNDKKLLLEGFPQKTIFESLDEAGFSFGIYYQFPPSTLFYRNLRKLKYLTHFHQYGIQFKKDCKEGKLPNYVVVEQRWFDLLSTPANDDHPSHDVSEGQKLVKEVYEALRSSPQWNEILFIITYDEHGGFYDHVPTPVDGVPNPDGILGPPPYNFEFNRLGVRVPTFFISPWIEPGTVIHGPNGPYPRSQYEHSSIPATVKTIFKLKDFLSKRDSWAGTFESVITRDSPRQDCPETLSTPIKLRGTMAKENAQLSEFQEDLVIMAAGLKGDYKNEELIHKLCKETCVADASKYVTNAFEKFLEESRKARDRGCDENDIVYCVDDDDDHVVIPPQSHSEASNAAAQPKTQTSFFNKLFSCFIRHD

Gene Information

Entrez Gene ID
821243
Gene Name
non-specific phospholipase C4
Gene Symbol
NPC4
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005886 IDA:TAIR C plasma membrane
GO:0034480 IEA:UniProtKB-EC F phosphatidylcholine phospholipase C activity
GO:0004629 IDA:TAIR F phospholipase C activity
GO:0009395 IDA:TAIR P phospholipid catabolic process
GO:0006950 IEA:UniProtKB-KW P response to stress

KEGG Pathway Links

KEGG Pathway ID Description
ath00565 Ether lipid metabolism
ath00564 Glycerophospholipid metabolism
ath00562 Inositol phosphate metabolism
ath01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR017850 Alkaline-phosphatase-like, core domain
IPR007312 Phosphoesterase

UniProt Annotations

Entry Information

Gene Name
non-specific phospholipase C4
Protein Entry
NPC4_ARATH
UniProt ID
Q9SRQ7
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity A phosphatidylcholine + H(2)O = 1,2-diacyl-sn- glycerol + phosphocholine. {ECO:0000269|PubMed:15618226}.
Disruption Phenotype No visible phenotype under normal growth conditions, but mutant plants display decreased ABA sensitivity in seed germination, root elongation, and stomatal movement and have decreased tolerance to high salinity and water deficiency. Root hair elongation defects under low inorganic phosphate conditions. {ECO:0000269|PubMed:15618226, ECO:0000269|PubMed:20507939, ECO:0000269|PubMed:20699393, ECO:0000269|PubMed:21525137, ECO:0000269|PubMed:23432399}.
Function Non-specific phospholipase C (PLC) which assumes major PLC activity during inorganic phosphate starvation. Substrate preference is phosphatidylcholine (PC), but can also hydrolyze phosphatidylethanolamine (PE) with lower efficiency. Has no activity toward phosphatidic acid (PA). Plays an important role in the supply of both inorganic phosphate and diacylglycerol from membrane-localized phospholipids during phosphate deprivation. May be required for lipid-derived signaling molecules that positively modulate abscisic acid (ABA) response and promote plant tolerance to drought and salt stresses. May be involved in brassinolide- mediated signaling in root development. {ECO:0000269|PubMed:15618226, ECO:0000269|PubMed:20507939, ECO:0000269|PubMed:20699393, ECO:0000269|PubMed:21525137}.
Induction Induced by auxin, zeatin, salt and inorganic phosphate deprivation. {ECO:0000269|PubMed:15618226, ECO:0000269|PubMed:20507939, ECO:0000269|PubMed:21525137}.
Similarity Belongs to the bacterial phospholipase C family. {ECO:0000305}.
Subcellular Location Cell membrane {ECO:0000305|PubMed:15618226}; Peripheral membrane protein {ECO:0000305|PubMed:15618226}.
Tissue Specificity Expressed in root tips, cotyledons, on leaf margins, stems, young anthers and funiculus. {ECO:0000269|PubMed:20507939}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010681 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18396577 RefSeq NP_566206 538 non-specific phospholipase C4

Identical Sequences to LMP010681 proteins

Reference Database Accession Length Protein Name
GI:18396577 DBBJ BAC22508.1 538 phosphatidylglycerol specific phospholipase C [Arabidopsis thaliana]
GI:18396577 GenBank AAF01582.1 538 hypothetical protein [Arabidopsis thaliana]
GI:18396577 GenBank AAK59858.1 538 AT3g03530/T21P5_5 [Arabidopsis thaliana]
GI:18396577 GenBank AAN28886.1 538 At3g03530/T21P5_5 [Arabidopsis thaliana]
GI:18396577 GenBank AEE73954.1 538 non-specific phospholipase C4 [Arabidopsis thaliana]
GI:18396577 SwissProt Q9SRQ7.1 538 RecName: Full=Non-specific phospholipase C4 [Arabidopsis thaliana]

Related Sequences to LMP010681 proteins

Reference Database Accession Length Protein Name
GI:18396577 GenBank EFH60650.1 538 hypothetical protein ARALYDRAFT_317234 [Arabidopsis lyrata subsp. lyrata]
GI:18396577 RefSeq XP_002884391.1 538 hypothetical protein ARALYDRAFT_317234 [Arabidopsis lyrata subsp. lyrata]
GI:18396577 RefSeq XP_010511520.1 534 PREDICTED: non-specific phospholipase C4-like [Camelina sativa]
GI:18396577 RefSeq XP_010463802.1 535 PREDICTED: non-specific phospholipase C4 isoform X1 [Camelina sativa]
GI:18396577 RefSeq XP_010463803.1 535 PREDICTED: non-specific phospholipase C4 isoform X2 [Camelina sativa]
GI:18396577 RefSeq XP_010485693.1 540 PREDICTED: non-specific phospholipase C4-like [Camelina sativa]