Gene/Proteome Database (LMPD)

LMPD ID
LMP010624
Gene ID
832804
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
mevalonate kinase
Gene Symbol
MK
Synonyms
F21A20.160; F21A20_160; mevalonate kinase; MEVALONATE KINASE; MK; MVK
Alternate Names
mevalonate kinase
Chromosome
5
EC Number
2.7.1.36

Proteins

mevalonate kinase
Refseq ID NP_001190411
Protein GI 334187979
UniProt ID P46086
mRNA ID NM_001203482
Length 378
RefSeq Status REVIEWED
MEVKARAPGKIILAGEHAVVHGSTAVAAAIDLYTYVTLRFPLPSAENNDRLTLQLKDISLEFSWSLARIKEAIPYDSSTLCRSTPASCSEETLKSIAVLVEEQNLPKEKMWLSSGISTFLWLYTRIIGFNPATVVINSELPYGSGLGSSAALCVALTAALLASSISEKTRGNGWSSLDETNLELLNKWAFEGEKIIHGKPSGIDNTVSAYGNMIKFCSGEITRLQSNMPLRMLITNTRVGRNTKALVSGVSQRAVRHPDAMKSVFNAVDSISKELAAIIQSKDETSVTEKEERIKELMEMNQGLLLSMGVSHSSIEAVILTTVKHKLVSKLTGAGGGGCVLTLLPTGTVVDKVVEELESSGFQCFTALIGGNGAQICY
mevalonate kinase
Refseq ID NP_851084
Protein GI 30690651
UniProt ID P46086
mRNA ID NM_180753
Length 378
RefSeq Status REVIEWED
Protein sequence is identical to GI:334187979 (mRNA isoform)
mevalonate kinase
Refseq ID NP_198097
Protein GI 15240936
UniProt ID P46086
mRNA ID NM_122627
Length 378
RefSeq Status REVIEWED
Protein sequence is identical to GI:334187979 (mRNA isoform)

Gene Information

Entrez Gene ID
832804
Gene Name
mevalonate kinase
Gene Symbol
MK
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:TAIR C cytosol
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004496 IGI:TAIR F mevalonate kinase activity
GO:0019287 IEA:UniProtKB-UniPathway P isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0016126 IEA:UniProtKB-KW P sterol biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath_M00095 C5 isoprenoid biosynthesis, mevalonate pathway
ath04146 Peroxisome
ath00900 Terpenoid backbone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
6254036 Cholesterol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR006204 GHMP kinase N-terminal domain
IPR006203 GHMP kinase, ATP-binding, conserved site
IPR013750 GHMP kinase, C-terminal domain
IPR006205 Mevalonate kinase
IPR006206 Mevalonate/galactokinase
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup

UniProt Annotations

Entry Information

Gene Name
mevalonate kinase
Protein Entry
KIME_ARATH
UniProt ID
P46086
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity ATP + (R)-mevalonate = ADP + (R)-5- phosphomevalonate.
Enzyme Regulation Its activity is inhibited in vitro by geranyl pyrophosphate (GPP) and farnesyl pyrophosphate (FPP) that bind competitively at the ATP-binding site on the enzyme.
Pathway Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
Sequence Caution Sequence=AAD45421.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the GHMP kinase family. Mevalonate kinase subfamily. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010624 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
334187979 RefSeq NP_001190411 378 mevalonate kinase

Identical Sequences to LMP010624 proteins

Reference Database Accession Length Protein Name
GI:334187979 GenBank AAN72115.1 378 mevalonate kinase [Arabidopsis thaliana]
GI:334187979 GenBank ADI53347.1 378 Sequence 5 from patent US 7422884
GI:334187979 gnl TAIR 378 mevalonate kinase [Arabidopsis thaliana]
GI:334187979 gnl TAIR 378 mevalonate kinase [Arabidopsis thaliana]
GI:334187979 gnl TAIR 378 mevalonate kinase [Arabidopsis thaliana]
GI:334187979 RefSeq NP_851084.1 378 mevalonate kinase [Arabidopsis thaliana]

Related Sequences to LMP010624 proteins

Reference Database Accession Length Protein Name
GI:334187979 GenBank AAD45421.1 376 mevalonate kinase [Arabidopsis thaliana]
GI:334187979 GenBank EFH50630.1 378 hypothetical protein ARALYDRAFT_489582 [Arabidopsis lyrata subsp. lyrata]
GI:334187979 RefSeq XP_002874371.1 378 hypothetical protein ARALYDRAFT_489582 [Arabidopsis lyrata subsp. lyrata]
GI:334187979 RefSeq XP_010455122.1 378 PREDICTED: mevalonate kinase-like isoform X1 [Camelina sativa]
GI:334187979 RefSeq XP_010455123.1 378 PREDICTED: mevalonate kinase-like isoform X2 [Camelina sativa]
GI:334187979 RefSeq XP_010494008.1 378 PREDICTED: mevalonate kinase [Camelina sativa]