Gene/Proteome Database (LMPD)

LMPD ID
LMP010556
Gene ID
843584
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
lipoxygenase 4
Gene Symbol
AT1G72520
Synonyms
T10D10.1; T10D10_1
Alternate Names
lipoxygenase 4
Chromosome
1
EC Number
1.13.11.12

Proteins

lipoxygenase 4
Refseq ID NP_177396
Protein GI 15218506
UniProt ID Q9FNX8
mRNA ID NM_105911
Length 926
RefSeq Status REVIEWED
MALANEIMGSRLIFERSSSLASPFHSRFSIKKKTQRTQFSINPFDPRPMRAVNSSGVVAAISEDLVKTLRISTVGRKQEKEEEEEKSVKFKVRAVATVRNKNKEDFKETLVKHLDAFTDKIGRNVVLELMSTQVDPKTNEPKKSKAAVLKDWSKKSNSKAERVHYTAEFTVDSAFGSPGAITVTNKHQKEFFLESITIEGFACGPVHFPCNSWVQSQKDHPSKRILFTNQPYLPSETPSGLRTLREKELENLRGNGKGERKLSDRIYDYDVYNDIGNPDISRELARPTLGGREFPYPRRCRTGRSSTDTDMMSERRVEKPLPMYVPRDEQFEESKQNTFAACRLKAVLHNLIPSLKASILAEDFANFGEIDSLYKEGLLLKLGFQDDMFKKFPLPKIVTTLQKSSEGLLRYDTPKIVSKDKYAWLRDDEFARQAIAGINPVNIERVTSYPPVSNLDPEIYGPGLHSALTEDHIIGQLDGLTVQQALETNRLFMVDYHDIYLPFLDRINALDGRKAYATRTILFLTRLGTLKPIAIELSLPSQSSSNQKSKRVVTPPVDATSNWMWQLAKAHVGSNDAGVHQLVNHWLRTHACLEPFILAAHRQLSAMHPIFKLLDPHMRYTLEINAVARQTLISADGVIESCFTAGQYGLEISSAAYKNKWRFDMEGLPADLIRRGMAVPDPTQPHGLKLLVEDYPYANDGLLLWSAIQTWVRTYVERYYANSNLIQTDTELQAWYSESINVGHADHRDAEWWPKLSTVEDLVSVITTIIWLASAQHAALNFGQYPYGGYVPNRPPLMRRLIPDESDPEFTSFIEDPQKYFFSSMPSLLQTTKFMAVVDTLSTHSPDEEYIGERQQPSIWTGDAEIVDAFYGFSAEIGRIEKEIDKRNRDPSRRNRCGAGVLPYELMAPSSEPGVTCRGVPNSVSI

Gene Information

Entrez Gene ID
843584
Gene Name
lipoxygenase 4
Gene Symbol
AT1G72520
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IEA:UniProtKB-KW C chloroplast
GO:0005506 IEA:InterPro F iron ion binding
GO:0016165 IDA:UniProtKB F linoleate 13S-lipoxygenase activity
GO:0009901 IGI:TAIR P anther dehiscence
GO:0048653 IGI:TAIR P anther development
GO:0034440 IDA:TAIR P lipid oxidation
GO:0031408 IEA:UniProtKB-UniPathway P oxylipin biosynthetic process
GO:0009555 IGI:TAIR P pollen development
GO:0009617 IEP:UniProtKB P response to bacterium
GO:0010193 IEP:UniProtKB P response to ozone
GO:0009611 IEP:UniProtKB P response to wounding
GO:0080086 IGI:TAIR P stamen filament development

KEGG Pathway Links

KEGG Pathway ID Description
ath_M00113 Jasmonic acid biosynthesis
ath00591 Linoleic acid metabolism
ath01100 Metabolic pathways
ath00592 alpha-Linolenic acid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR000907 Lipoxygenase
IPR013819 Lipoxygenase, C-terminal
IPR020834 Lipoxygenase, conserved site
IPR027433 Lipoxygenase, domain 3
IPR020833 Lipoxygenase, iron binding site
IPR001246 Lipoxygenase, plant
IPR001024 PLAT/LH2 domain

UniProt Annotations

Entry Information

Gene Name
lipoxygenase 4
Protein Entry
LOX4_ARATH
UniProt ID
Q9FNX8
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Alpha-linolenate + O(2) = (9Z,11E,13S,15Z)-13- hydroperoxyoctadeca-9,11,15-trienoate.
Catalytic Activity Linoleate + O(2) = (9Z,11E,13S)-13- hydroperoxyoctadeca-9,11-dienoate.
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875; Evidence={ECO:0000255|PROSITE-ProRule:PRU00726}; Note=Binds 1 Fe cation per subunit. {ECO:0000255|PROSITE- ProRule:PRU00726};
Developmental Stage Expression is greatly increased in leaves during leaf senescence. {ECO:0000269|PubMed:11891244}.
Function Plant lipoxygenases may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding. Catalyzes the hydroperoxidation of lipids containing a cis,cis-1,4-pentadiene structure (By similarity). 13S-lipoxygenase that can use linolenic acid as substrates. {ECO:0000255|PROSITE- ProRule:PRU00726, ECO:0000269|PubMed:18949503}.
Induction Induced by bacterial pathogens (e.g. Pseudomonas syringae pv. tomato), ozone O(3), and wounding. {ECO:0000269|PubMed:12609040, ECO:0000269|PubMed:19054359}.
Pathway Lipid metabolism; oxylipin biosynthesis. {ECO:0000255|PROSITE-ProRule:PRU00726}.
Similarity Belongs to the lipoxygenase family. {ECO:0000305}.
Similarity Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Similarity Contains 1 lipoxygenase domain. {ECO:0000255|PROSITE- ProRule:PRU00726}.
Subcellular Location Plastid, chloroplast {ECO:0000305}.
Tissue Specificity Expressed in leaves. {ECO:0000269|PubMed:17369372}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010556 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15218506 RefSeq NP_177396 926 lipoxygenase 4

Identical Sequences to LMP010556 proteins

Reference Database Accession Length Protein Name
GI:15218506 EMBL CAC19364.1 926 lipoxygenase, partial [Arabidopsis thaliana]
GI:15218506 GenBank AAG52571.1 926 putative lipoxygenase; 4618-640 [Arabidopsis thaliana]
GI:15218506 GenBank AAL07015.1 926 putative lipoxygenase [Arabidopsis thaliana]
GI:15218506 GenBank AAM14132.1 926 putative lipoxygenase [Arabidopsis thaliana]
GI:15218506 GenBank AEE35334.1 926 lipoxygenase 4 [Arabidopsis thaliana]
GI:15218506 SwissProt Q9FNX8.1 926 RecName: Full=Lipoxygenase 4, chloroplastic; Short=AtLOX4; AltName: Full=LOX3-like protein; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP010556 proteins

Reference Database Accession Length Protein Name
GI:15218506 GenBank EFH63696.1 921 hypothetical protein ARALYDRAFT_476385 [Arabidopsis lyrata subsp. lyrata]
GI:15218506 GenBank EOA33502.1 925 hypothetical protein CARUB_v10019743mg [Capsella rubella]
GI:15218506 RefSeq XP_002887437.1 921 hypothetical protein ARALYDRAFT_476385 [Arabidopsis lyrata subsp. lyrata]
GI:15218506 RefSeq XP_006300604.1 925 hypothetical protein CARUB_v10019743mg [Capsella rubella]
GI:15218506 RefSeq XP_010428139.1 924 PREDICTED: lipoxygenase 4, chloroplastic [Camelina sativa]
GI:15218506 RefSeq XP_010471279.1 924 PREDICTED: lipoxygenase 4, chloroplastic-like [Camelina sativa]