Gene/Proteome Database (LMPD)

LMPD ID
LMP010530
Gene ID
831196
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
peptidase M1 family protein
Gene Symbol
AT5G13520
Synonyms
T6I14.50; T6I14_50
Alternate Names
peptidase M1 family protein
Chromosome
5
EC Number
3.3.2.6

Proteins

peptidase M1 family protein
Refseq ID NP_196856
Protein GI 15240645
UniProt ID Q9FY49
mRNA ID NM_121355
Length 616
RefSeq Status REVIEWED
MAPIDPHSFTDSSHPLTTHVALSLYLDFNTSIIHGSALLTLSSAFSGELSLDTRCISIAMVLDPLTLEPIPYSVSTTPDRIRGTEVVVVLSGQSSLLIVYSTSPSASALQWLSPLQTFSKLHPYVYTQCQAIHARSIFPCQDTPAARIRYDVVMNIPNSLSAVMSARHVRRRLAVPEEAKHLEAGSLGSSLWCGEDRVVEEFAMEQPIPPYLFAFAVGELGFREVGPRTRVYTESAAIEVLDAAALEFAGTEDMIKQGEKLFGDYEWERFDLLVLPPSFPYGGMENPRMVFLTPTVIKGDATGAQVVAHELAHSWTGNLITNINNEHFWLNEGFTTYAERRIVEVVQGADIATLNIGIGWRGLTDEMERFKDNLECTKLWNKQEGVDPDDVYSQVPYEKGFQFVLRIERQIGRTAFDEFLKKYIATFKFKSIDTNTFLEFLKANIPGIEKEINLQLWTEGVGIPEDAYEPVSTIYTKIISLAKEFKEGKMPSEDDVAEWNGQEWELYLENLPKSCEPSQVMALDKRYRLAESKDYEVKVSFLQLAVTSKCREYHGEVKKTLKEVGRMKYLRPLFTALAQSGGTEEKQLAKQVFAEARETYHPIAQGVVESILSKYI

Gene Information

Entrez Gene ID
831196
Gene Name
peptidase M1 family protein
Gene Symbol
AT5G13520
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:TAIR C cytosol
GO:0004463 IEA:UniProtKB-EC F leukotriene-A4 hydrolase activity
GO:0008237 IEA:UniProtKB-KW F metallopeptidase activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0019370 IEA:UniProtKB-KW P leukotriene biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00590 Arachidonic acid metabolism
ath01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
6253812 Arachidonic acid metabolism
6254113 Synthesis of Leukotrienes (LT) and Eoxins (EX)

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal

UniProt Annotations

Entry Information

Gene Name
peptidase M1 family protein
Protein Entry
LKHA4_ARATH
UniProt ID
Q9FY49
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa- 7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12- dihydroxyicosa-6,8,10,14-tetraenoate.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000250}; Note=Binds 1 zinc ion per subunit. {ECO:0000250};
Function Aminopeptidase that preferentially cleaves tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze an epoxide moiety of LTA(4) to form LTB(4) (in vitro) (By similarity). {ECO:0000250}.
Pathway Lipid metabolism; leukotriene B4 biosynthesis.
Sequence Caution Sequence=BAD94611.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Belongs to the peptidase M1 family. {ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010530 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15240645 RefSeq NP_196856 616 peptidase M1 family protein

Identical Sequences to LMP010530 proteins

Reference Database Accession Length Protein Name
GI:15240645 EMBL CAC05429.1 616 leukotriene-A4 hydrolase-like protein [Arabidopsis thaliana]
GI:15240645 GenBank AAL67031.1 616 putative leukotriene-A4 hydrolase [Arabidopsis thaliana]
GI:15240645 GenBank AAM91766.1 616 putative leukotriene-A4 hydrolase [Arabidopsis thaliana]
GI:15240645 gnl TAIR 616 peptidase M1 family protein [Arabidopsis thaliana]
GI:15240645 SwissProt Q9FY49.1 616 RecName: Full=Leukotriene A-4 hydrolase homolog; Short=LTA-4 hydrolase; AltName: Full=Leukotriene A(4) hydrolase [Arabidopsis thaliana]

Related Sequences to LMP010530 proteins

Reference Database Accession Length Protein Name
GI:15240645 GenBank EFH49875.1 616 peptidase M1 family protein [Arabidopsis lyrata subsp. lyrata]
GI:15240645 GenBank EOA20189.1 616 hypothetical protein CARUB_v10000485mg [Capsella rubella]
GI:15240645 RefSeq XP_002873616.1 616 peptidase M1 family protein [Arabidopsis lyrata subsp. lyrata]
GI:15240645 RefSeq XP_006287291.1 616 hypothetical protein CARUB_v10000485mg [Capsella rubella]
GI:15240645 RefSeq XP_010453430.1 616 PREDICTED: leukotriene A-4 hydrolase homolog [Camelina sativa]
GI:15240645 RefSeq XP_010492111.1 616 PREDICTED: leukotriene A-4 hydrolase homolog [Camelina sativa]