Gene/Proteome Database (LMPD)

LMPD ID
LMP010526
Gene ID
823649
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
lanosterol synthase 1
Gene Symbol
LAS1
Synonyms
lanosterol synthase 1; LAS1
Alternate Names
lanosterol synthase 1
Chromosome
3
EC Number
5.4.99.7

Proteins

lanosterol synthase 1
Refseq ID NP_190099
Protein GI 145339142
UniProt ID Q1G1A4
mRNA ID NM_114382
Length 756
RefSeq Status REVIEWED
MWRLKLSEGDEESVNQHVGRQFWEYDNQFGTSEERHHINHLRSNFTLNRFSSKHSSDLLYRFQCWKEKGKGMERLPQVKVKEGEERLINEEVVNVTLRRSLRFYSILQSQDGFWPGDYGGPLFLLPALVIGLYVTEVLDGTLTAQHQIEIRRYLYNHQNKDGGWGLHVEGNSTMFCTVLSYVALRLMGEELDGGDGAMESARSWIHHHGGATFIPSWGKFWLSVLGAYEWSGNNPLPPELWLLPYSLPFHPGRMWCHCRMVYLPMSYLYGRRFVCRTNGTILSLRRELYTIPYHHIDWDTARNQCAKEDLYYPHPKIQDVLWSCLNKFGEPLLERWPLNNLRNHALQTVMQHIHYEDQNSHYICIGPVNKVLNMLCCWVESSNSEAFKSHLSRIKDYLWVAEDGMKMQGYNGSQLWDVTLAVQAILATNLVDDYGLMLKKAHNYIKNTQIRKDTSGDPGLWYRHPCKGGWGFSTGDNPWPVSDCTAEALKAALLLSQMPVNLVGEPMPEEHLVDAVNFILSLQNKNGGFASYELTRSYPELEVINPSETFGDIIIDYQYVECTSAAIQGLVLFTTLNSSYKRKEIVGSINKAVEFIEKTQLPDGSWYGSWGVCFTYATWFGIKGMLASGKTYESSLCIRKACGFLLSKQLCCGGWGESYLSCQNKVYTNLPGNKSHIVNTSWALLALIEAGQASRDPMPLHRGAKSLINSQMEDGDYPQQEILGVFNRNCMISYSAYRNIFPIWALGEYRKLMLSL

Gene Information

Entrez Gene ID
823649
Gene Name
lanosterol synthase 1
Gene Symbol
LAS1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000250 IDA:TAIR F lanosterol synthase activity

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath01100 Metabolic pathways
ath00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
6254036 Cholesterol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001330 Prenyltransferase/squalene oxidase
IPR018333 Squalene cyclase
IPR002365 Terpene synthase, conserved site
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

UniProt Annotations

Entry Information

Gene Name
lanosterol synthase 1
Protein Entry
LAS1_ARATH
UniProt ID
Q1G1A4
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity (3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol.
Disruption Phenotype No visible phenotype. {ECO:0000269|PubMed:16531458}.
Function Converts oxidosqualene to lanosterol. {ECO:0000269|PubMed:16445886, ECO:0000269|PubMed:16531458}.
Sequence Caution Sequence=CAB72151.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the terpene cyclase/mutase family. {ECO:0000305}.
Similarity Contains 4 PFTB repeats. {ECO:0000305}.
Tissue Specificity Expressed in roots, stems and siliques. Low expression in rosette leaves. {ECO:0000269|PubMed:16531458}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010526 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
145339142 RefSeq NP_190099 756 lanosterol synthase 1

Identical Sequences to LMP010526 proteins

Reference Database Accession Length Protein Name
GI:145339142 DBBJ BAE95408.1 756 lanosterol synthase [Arabidopsis thaliana]
GI:145339142 EMBL CAY34730.1 756 unnamed protein product [Arabidopsis thaliana]
GI:145339142 GenBank ABF57670.1 756 lanosterol synthase [Arabidopsis thaliana]
GI:145339142 GenBank AEE77996.1 756 lanosterol synthase 1 [Arabidopsis thaliana]
GI:145339142 SwissProt Q1G1A4.1 756 RecName: Full=Lanosterol synthase [Arabidopsis thaliana]

Related Sequences to LMP010526 proteins

Reference Database Accession Length Protein Name
GI:145339142 EMBL CAY34699.1 742 unnamed protein product [Arabidopsis thaliana]
GI:145339142 EMBL CAY34707.1 748 unnamed protein product [Arabidopsis thaliana]
GI:145339142 EMBL CBG17613.1 742 unnamed protein product [Arabidopsis thaliana]
GI:145339142 EMBL CBG17705.1 742 unnamed protein product [Arabidopsis thaliana]
GI:145339142 GenBank ACX07501.1 742 Sequence 31426 from patent US 7569389
GI:145339142 GenBank AGY09222.1 742 Sequence 98566 from patent US 8541208