Gene/Proteome Database (LMPD)

LMPD ID
LMP010524
Gene ID
821460
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
LAG1 longevity assurance-like 2
Gene Symbol
LOH2
Synonyms
LAG1 HOMOLOG 2; LAG1 homologue 2; LOH2; LONGEVITY ASSURANCE GENE1 HOMOLOG 2
Alternate Names
LAG1 longevity assurance-like 2
Chromosome
3
Summary
LAG1 homolog . Loss of function mutant is sensitive to AAL-toxin. LOH2 is presumed to function in sphingolipid metabolism.
Orthologs
View orthologs and multiple alignments for LOH2

Proteins

LAG1 longevity assurance-like 2
Refseq ID NP_188557
Protein GI 15230323
UniProt ID Q9LJK3
mRNA ID NM_112813
Length 296
RefSeq Status REVIEWED
MESVSSRGGDPVVKPSMEVWHFQIAVYFAFGFFFLRLVLDRYVFQRIALWLLSTGSAPIKLNDAATRAKIVKCKESLWKLLYYAACDFFVLQVIYHEPWARDIKLYFHGWPNQELKLSIKLYYMCQCGFYVYGVAALLAWETRRKDFAVMMSHHVITIILLSYSYLTSFFRIGAIILALHDASDVFMETAKIFKYSEKEFGASVCFALFAVSWLLLRLIYFPFWIIRATSIELLDYLDMTSAEGTLMYYSFNTMLLMLLVFHIYWWYLICAMIVRLLKNRGKVGEDIRSDSEDDDD

Gene Information

Entrez Gene ID
821460
Gene Name
LAG1 longevity assurance-like 2
Gene Symbol
LOH2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:TAIR C Golgi apparatus
GO:0005783 IDA:TAIR C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IDA:TAIR C plasma membrane
GO:0050291 IMP:TAIR F sphingosine N-acyltransferase activity
GO:0042759 IMP:TAIR P long-chain fatty acid biosynthetic process
GO:0002238 IMP:TAIR P response to molecule of fungal origin

REACTOME Pathway Links

REACTOME Pathway ID Description
6253653 Metabolism
6253725 Metabolism of lipids and lipoproteins
6254191 Sphingolipid de novo biosynthesis
6254192 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016439 Longevity assurance, LAG1/LAC1
IPR006634 TRAM/LAG1/CLN8 homology domain

UniProt Annotations

Entry Information

Gene Name
LAG1 longevity assurance-like 2
Protein Entry
LAG12_ARATH
UniProt ID
Q9LJK3
Species
Arabidopsis

Comments

Comment Type Description
Function Mediates resistance to sphinganine-analog mycotoxins (SAMs) by restoring the sphingolipid biosynthesis. Could salvage the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi apparatus in ceramides-depleted cells after SAM exposure (By similarity). {ECO:0000250}.
Similarity Contains 1 TLC (TRAM/LAG1/CLN8) domain. {ECO:0000255|PROSITE-ProRule:PRU00205}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010524 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15230323 RefSeq NP_188557 296 LAG1 longevity assurance-like 2

Identical Sequences to LMP010524 proteins

Reference Database Accession Length Protein Name
GI:15230323 DBBJ BAB02967.1 296 unnamed protein product [Arabidopsis thaliana]
GI:15230323 DBBJ BAC42661.1 296 putative longevity factor [Arabidopsis thaliana]
GI:15230323 GenBank AAM61539.1 296 longevity factor-like protein [Arabidopsis thaliana]
GI:15230323 GenBank AAP37700.1 296 At3g19260 [Arabidopsis thaliana]
GI:15230323 GenBank AEE76214.1 296 LAG1 longevity assurance-like 2 [Arabidopsis thaliana]
GI:15230323 SwissProt Q9LJK3.1 296 RecName: Full=LAG1 longevity assurance homolog 2; Short=LAG1 homolog 2 [Arabidopsis thaliana]

Related Sequences to LMP010524 proteins

Reference Database Accession Length Protein Name
GI:15230323 GenBank AAF66103.1 297 LAG1 homolog 2 [Arabidopsis thaliana]
GI:15230323 GenBank EOA31121.1 298 hypothetical protein CARUB_v10014281mg [Capsella rubella]
GI:15230323 GenBank ESQ47972.1 297 hypothetical protein EUTSA_v10021239mg [Eutrema salsugineum]
GI:15230323 RefSeq XP_006298223.1 298 hypothetical protein CARUB_v10014281mg [Capsella rubella]
GI:15230323 RefSeq XP_006406519.1 297 hypothetical protein EUTSA_v10021239mg [Eutrema salsugineum]
GI:15230323 RefSeq XP_010487857.1 299 PREDICTED: LAG1 longevity assurance homolog 2 [Camelina sativa]