Gene/Proteome Database (LMPD)

LMPD ID
LMP010520
Gene ID
820960
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
Isopentenyl-diphosphate Delta-isomerase II
Gene Symbol
IPP2
Synonyms
ATISOPENTENYL DIPHOSPHE ISOMERASE 2; F13E7.28; F13E7_28; IDI2; IPIAT1; IPP2; isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase 2; ISOPENTENYL PYROPHOSPHATE:DIMETHYLLALLYL PYROPHOSPHATE ISOMERASE
Alternate Names
Isopentenyl-diphosphate Delta-isomerase II
Chromosome
3
EC Number
5.3.3.2
Summary
Encodes a protein with isopentenyl diphosphate:dimethylallyl diphosphate isomerase activity. There is genetic evidence that it functions in the mevalonate, but not the MEP biosynthetic pathway.
Orthologs
View orthologs and multiple alignments for IPP2

Proteins

Isopentenyl-diphosphate Delta-isomerase II
Refseq ID NP_186927
Protein GI 15232981
UniProt ID Q42553
mRNA ID NM_111146
Length 284
RefSeq Status REVIEWED
MSASSLFNLPLIRLRSLALSSSFSSFRFAHRPLSSISPRKLPNFRAFSGTAMTDTKDAGMDAVQRRLMFEDECILVDETDRVVGHDSKYNCHLMENIEAKNLLHRAFSVFLFNSKYELLLQQRSNTKVTFPLVWTNTCCSHPLYRESELIQDNALGVRNAAQRKLLDELGIVAEDVPVDEFTPLGRMLYKAPSDGKWGEHELDYLLFIVRDVKVQPNPDEVAEIKYVSREELKELVKKADAGEEGLKLSPWFRLVVDNFLMKWWDHVEKGTLVEAIDMKTIHKL

Gene Information

Entrez Gene ID
820960
Gene Name
Isopentenyl-diphosphate Delta-isomerase II
Gene Symbol
IPP2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IDA:TAIR C chloroplast
GO:0005829 IDA:TAIR C cytosol
GO:0005739 IDA:TAIR C mitochondrion
GO:0016787 IEA:InterPro F hydrolase activity
GO:0004452 IEA:UniProtKB-EC F isopentenyl-diphosphate delta-isomerase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0015995 IEA:UniProtKB-UniPathway P chlorophyll biosynthetic process
GO:0050992 IEA:UniProtKB-UniPathway P dimethylallyl diphosphate biosynthetic process
GO:0009908 IMP:TAIR P flower development
GO:0008299 IEA:UniProtKB-KW P isoprenoid biosynthetic process
GO:0015979 IEA:UniProtKB-KW P photosynthesis

KEGG Pathway Links

KEGG Pathway ID Description
ath_M00095 C5 isoprenoid biosynthesis, mevalonate pathway
ath_M00096 C5 isoprenoid biosynthesis, non-mevalonate pathway
ath00900 Terpenoid backbone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
6254036 Cholesterol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1
IPR000086 NUDIX hydrolase domain
IPR015797 NUDIX hydrolase domain-like

UniProt Annotations

Entry Information

Gene Name
Isopentenyl-diphosphate Delta-isomerase II
Protein Entry
IDI2_ARATH
UniProt ID
Q42553
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity Isopentenyl diphosphate = dimethylallyl diphosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000250};
Function Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). {ECO:0000250}.
Pathway Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.
Pathway Porphyrin-containing compound metabolism; chlorophyll biosynthesis.
Similarity Belongs to the IPP isomerase type 1 family. {ECO:0000305}.
Similarity Contains 1 nudix hydrolase domain. {ECO:0000255|PROSITE-ProRule:PRU00794}.
Subcellular Location Plastid, chloroplast {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010520 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15232981 RefSeq NP_186927 284 Isopentenyl-diphosphate Delta-isomerase II

Identical Sequences to LMP010520 proteins

Reference Database Accession Length Protein Name
GI:15232981 EMBL CAJ76622.1 284 unnamed protein product [Arabidopsis thaliana]
GI:15232981 GenBank AAL16273.1 284 AT3g02780/F13E7_28 [Arabidopsis thaliana]
GI:15232981 GenBank AAM83247.1 284 AT3g02780/F13E7_28 [Arabidopsis thaliana]
GI:15232981 GenBank AAN28784.1 284 At3g02780/F13E7_28 [Arabidopsis thaliana]
GI:15232981 GenBank AEE73859.1 284 Isopentenyl-diphosphate Delta-isomerase II [Arabidopsis thaliana]
GI:15232981 GenBank AGM81197.1 284 Sequence 96 from patent US 8426681

Related Sequences to LMP010520 proteins

Reference Database Accession Length Protein Name
GI:15232981 GenBank AAF29979.1 284 isopentenyl pyrophosphate:dimethyllallyl pyrophosphate isomerase [Arabidopsis thaliana]
GI:15232981 GenBank AAR75808.1 284 Sequence 16 from patent US 6642021
GI:15232981 GenBank EFH60598.1 283 hypothetical protein ARALYDRAFT_477520 [Arabidopsis lyrata subsp. lyrata]
GI:15232981 pat US 284 Sequence 16 from patent US 5744341
GI:15232981 RefSeq XP_002884339.1 283 hypothetical protein ARALYDRAFT_477520 [Arabidopsis lyrata subsp. lyrata]
GI:15232981 RefSeq XP_010463703.1 286 PREDICTED: isopentenyl-diphosphate Delta-isomerase II, chloroplastic [Camelina sativa]