Gene/Proteome Database (LMPD)

LMPD ID
LMP010516
Gene ID
819003
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
inositol-tetrakisphosphate 1-kinase 4
Gene Symbol
ITPK4
Synonyms
3; 4-trisphosphate 5/6-kinase 4; AtITPK4; F6E13.11; inositol 1; ITPK4
Alternate Names
inositol-tetrakisphosphate 1-kinase 4
Chromosome
2
EC Number
2.7.1.134

Proteins

inositol-tetrakisphosphate 1-kinase 4
Refseq ID NP_850407
Protein GI 30689569
UniProt ID O80568
mRNA ID NM_180076
Length 488
RefSeq Status REVIEWED
MKGVLLDESVLFSPESEDSSPSLRESVPSLLRLLRYSMIRTGISYGLDLPENKVDLLRKTAAEYSINCLPLETSLTSVTFGDTLKAWYSDGSILYVASSRKEEILRELSPSQLVVLLDVEGDSLEDPNIIHIHSLEELPMTICCINKKAMGDGAAIVAYIMKPSRVEDFAKRGALPMYPTSCGLIFLPLMFEFPLASQLKHADIIFHKATDEILSIELNCSDSKSSVAVTFSTGMEKLKKYMEDQNACAIVDPIRNIYPVVDRLKMQHILLGLEGLGAAGRKIRGACFLKIDSYDEPDLAQNLSRAGLSLPCIVKPQVACGVADAHSMAIVFRVEDFKNLNTPVPAIIQEYVDHSSRIFKFYVLGETIFHAVKKSIPSSSSLRKSAEENGLKPILFDSLKSLPVDSANQNPVSEIDLELVTEAATWLRKKLDLTIFGFDVVIQEGTGDHVIVDLNYLPSFKEVPDNIAVPAFWEAIRNRFDQHVQEKH

Gene Information

Entrez Gene ID
819003
Gene Name
inositol-tetrakisphosphate 1-kinase 4
Gene Symbol
ITPK4
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:TAIR C cytosol
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0047325 IEA:UniProtKB-EC F inositol tetrakisphosphate 1-kinase activity
GO:0052726 IEA:UniProtKB-EC F inositol-1,3,4-trisphosphate 5-kinase activity
GO:0052725 IEA:UniProtKB-EC F inositol-1,3,4-trisphosphate 6-kinase activity
GO:0000287 IEA:InterPro F magnesium ion binding
GO:0032957 IEA:InterPro P inositol trisphosphate metabolic process
GO:0010264 IMP:TAIR P myo-inositol hexakisphosphate biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
6254255 Factors involved in megakaryocyte development and platelet production
6254350 Inositol phosphate metabolism
6254351 Synthesis of IP3 and IP4 in the cytosol
6254352 Synthesis of pyrophosphates in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR008656 Inositol-tetrakisphosphate 1-kinase
IPR017418 Inositol-tetrakisphosphate 1-kinase 4

UniProt Annotations

Entry Information

Gene Name
inositol-tetrakisphosphate 1-kinase 4
Protein Entry
ITPK4_ARATH
UniProt ID
O80568
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
Catalytic Activity ATP + 1D-myo-inositol 1,3,4-trisphosphate = ADP + 1D-myo-inositol 1,3,4,6-tetrakisphosphate.
Catalytic Activity ATP + 1D-myo-inositol 3,4,5,6- tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 2 magnesium ions per subunit. {ECO:0000250};
Function Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway (By similarity). {ECO:0000250}.
Sequence Caution Sequence=AAC23406.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the ITPK1 family. {ECO:0000305}.
Similarity Contains 1 ATP-grasp domain. {ECO:0000305}.
Subunit Monomer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010516 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
30689569 RefSeq NP_850407 488 inositol-tetrakisphosphate 1-kinase 4

Identical Sequences to LMP010516 proteins

Reference Database Accession Length Protein Name
GI:30689569 GenBank AAL49852.1 488 unknown protein [Arabidopsis thaliana]
GI:30689569 GenBank AAM20216.1 488 unknown protein [Arabidopsis thaliana]
GI:30689569 GenBank AEC10358.1 488 inositol-tetrakisphosphate 1-kinase 4 [Arabidopsis thaliana]
GI:30689569 SwissProt O80568.2 488 RecName: Full=Inositol-tetrakisphosphate 1-kinase 4; AltName: Full=Inositol 1,3,4-trisphosphate 5/6-kinase 4; Short=AtItpk-4; Short=Inositol-triphosphate 5/6-kinase 4; Short=Ins(1,3,4)P(3) 5/6-kinase 4 [Arabidopsis thaliana]

Related Sequences to LMP010516 proteins

Reference Database Accession Length Protein Name
GI:30689569 EMBL CDX79790.1 488 BnaA05g03660D [Brassica napus]
GI:30689569 GenBank KFK37221.1 489 hypothetical protein AALP_AA4G229400 [Arabis alpina]
GI:30689569 RefSeq XP_006397572.1 494 hypothetical protein EUTSA_v10001421mg [Eutrema salsugineum]
GI:30689569 RefSeq XP_009142984.1 488 PREDICTED: inositol-tetrakisphosphate 1-kinase 4 [Brassica rapa]
GI:30689569 RefSeq XP_010506299.1 495 PREDICTED: inositol-tetrakisphosphate 1-kinase 4 [Camelina sativa]
GI:30689569 RefSeq XP_010508352.1 495 PREDICTED: inositol-tetrakisphosphate 1-kinase 4-like [Camelina sativa]