Gene/Proteome Database (LMPD)

LMPD ID
LMP010504
Gene ID
836298
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
inositol polyphosphate multikinase beta
Gene Symbol
IPK2BETA
Synonyms
ARABIDOPSIS THALIANA INOSITOL POLYPHOSPHATE KINASE 2 BETA; ATIPK2BETA; inositol polyphosphate kinase 2 beta; INOSITOL POLYPHOSPHATE KINASE 2 BETA; IPK2B; IPK2BETA; MAC9.7; MAC9_7
Alternate Names
inositol polyphosphate multikinase beta
Chromosome
5
EC Number
2.7.1.140

Proteins

inositol polyphosphate multikinase beta
Refseq ID NP_200984
Protein GI 15240350
UniProt ID Q9FLT2
mRNA ID NM_125570
Length 300
RefSeq Status REVIEWED
MLKVPEHQVAGHIASDGKLGPLVDDQGRFFKPLQGDSRGEHEAKFYESFTSNMKVPDHIHRYFPVYHGTQLVEASDGSGKLPHLVLDDVVSGYANPSVMDVKIGSRTWYPDVSEEYFKKCIKKDRQTTTVSLGFRVSGFKIFDHQESSFWRAEKKLVLGYNADGARLALRKFVSSNSPADSNLTPNCAFASEVYGGCNGILAQLLELKDWFETQTLYHFNSCSILMIYENESILMQGGDDAPAPRAQVKLVDFAHVLDGNGVIDHNFLGGLCSFIKFIKDILQSVEKHDETDTSLLENGR

Gene Information

Entrez Gene ID
836298
Gene Name
inositol polyphosphate multikinase beta
Gene Symbol
IPK2BETA
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IDA:TAIR C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0047326 IEA:UniProtKB-EC F inositol tetrakisphosphate 5-kinase activity
GO:0051765 IDA:TAIR F inositol tetrakisphosphate kinase activity
GO:0051766 IDA:TAIR F inositol trisphosphate kinase activity
GO:0052725 IDA:TAIR F inositol-1,3,4-trisphosphate 6-kinase activity
GO:0008440 IEA:InterPro F inositol-1,4,5-trisphosphate 3-kinase activity
GO:0000823 IDA:TAIR F inositol-1,4,5-trisphosphate 6-kinase activity
GO:0010264 IMP:TAIR P myo-inositol hexakisphosphate biosynthetic process
GO:0006355 TAS:TAIR P regulation of transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
ath00562 Inositol phosphate metabolism
ath_M00132 Inositol phosphate metabolism, Ins(1,3,4)P3 => phytate
ath01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
6254354 Synthesis of IPs in the nucleus

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate multikinase beta
Protein Entry
IPMKB_ARATH
UniProt ID
Q9FLT2
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
Catalytic Activity ATP + 1D-myo-inositol 1,3,4,6- tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6- pentakisphosphate.
Developmental Stage Expressed in mature pollen, but not in immature pollen grains. {ECO:0000269|PubMed:12566584}.
Disruption Phenotype Loss-of-function mutant atIpk2beta-1 (T-DNA insertion) is fully complemented by AtIPK2alpha in tissue but not in seeds, leading to the generation of phytate-free seeds. {ECO:0000269|PubMed:16107538}.
Function Inositol phosphate kinase with a broad substrate specificity. Phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), inositol 1,4,5,6-tetrakisphosphate (Ins(1,4,5,6)P4), inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4), inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) and inositol 1,2,3,4,6-pentakisphosphate (Ins(1,2,3,4,6)P5) but not inositol 1,4-bisphosphate (Ins(1,4)P2), inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), inositol 1,2,6- trisphosphate (Ins(1,2,6)P3), inositol 3,4,5,6-tetrakisphosphate (Ins(3,4,5,6)P4), inositol 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5), inositol 1,2,4,5,6-pentakisphosphate (Ins(1,2,4,5,6)P5) or inositol hexakisphosphate (InsP6). Involved in the auxin signaling pathway. Regulates axillary shoot branching and is required for phytate synthesis in seeds. {ECO:0000269|PubMed:12226109, ECO:0000269|PubMed:16107538, ECO:0000269|PubMed:17434984}.
Induction Induced by auxin, but not by salt, abscisic acid, manitol, water or drought. {ECO:0000269|PubMed:12566584, ECO:0000269|PubMed:17434984}.
Miscellaneous Does not bind calmodulin.
Ptm Phosphorylated. {ECO:0000269|PubMed:12566584}.
Similarity Belongs to the inositol phosphokinase (IPK) family. {ECO:0000305}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12566584}.
Tissue Specificity Expressed in leaves, stems, roots, siliques and flowers. Detected in vascular strands, stigma cells, the abscission zones of fully elongated siliques, the root central cylinder and the root tip. {ECO:0000269|PubMed:12226109, ECO:0000269|PubMed:12566584}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010504 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15240350 RefSeq NP_200984 300 inositol polyphosphate multikinase beta

Identical Sequences to LMP010504 proteins

Reference Database Accession Length Protein Name
GI:15240350 EMBL CAC43071.1 300 inositol-(1,4,5) trisphosphate 3-kinase [Arabidopsis thaliana]
GI:15240350 GenBank AAL06526.1 300 AT5g61760/mac9_60 [Arabidopsis thaliana]
GI:15240350 GenBank AAL62012.1 300 AT5g61760/mac9_60 [Arabidopsis thaliana]
GI:15240350 GenBank AAN63058.1 300 inositol polyphosphate 6-/3-/5-kinase 2b [Arabidopsis thaliana]
GI:15240350 gnl TAIR 300 inositol polyphosphate multikinase beta [Arabidopsis thaliana]
GI:15240350 SwissProt Q9FLT2.1 300 RecName: Full=Inositol polyphosphate multikinase beta; AltName: Full=Inositol polyphosphate 6-/3-/5-kinase beta; Short=AtIpk2-beta; Short=AtIpk2beta [Arabidopsis thaliana]

Related Sequences to LMP010504 proteins

Reference Database Accession Length Protein Name
GI:15240350 GenBank AAM63075.1 300 putative inositol hexaphosphate kinase [Arabidopsis thaliana]
GI:15240350 GenBank EFH42712.1 300 hypothetical protein ARALYDRAFT_496342 [Arabidopsis lyrata subsp. lyrata]
GI:15240350 GenBank EOA13771.1 300 hypothetical protein CARUB_v10026865mg [Capsella rubella]
GI:15240350 RefSeq XP_002866453.1 300 hypothetical protein ARALYDRAFT_496342 [Arabidopsis lyrata subsp. lyrata]
GI:15240350 RefSeq XP_006280873.1 300 hypothetical protein CARUB_v10026865mg [Capsella rubella]
GI:15240350 RefSeq XP_010457692.1 303 PREDICTED: inositol polyphosphate multikinase beta [Camelina sativa]