Gene/Proteome Database (LMPD)

LMPD ID
LMP010457
Gene ID
817208
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
heme oxygenase 1
Gene Symbol
TED4
Synonyms
ARABIDOPSIS THALIANA HEME OXYGENASE 1; ATHO1; F18A8.4; F18A8_4; GENOMES UNCOUPLED 2; GUN2; HEME OXYGENASE; HEME OXYGENASE 1; HEME OXYGENASE 6; HO1; HY1; HY6; PLASTID HEME OXYGENASE; REVERSAL OF THE DET PHENOTYPE 4; TED4
Alternate Names
heme oxygenase 1
Chromosome
2
EC Number
1.14.99.3
Summary
Encodes a plastid heme oxygenase necessary for phytochrome chromophore biosynthesis and for coupling the expression of some nuclear genes to the functional state of the chloroplast.
Orthologs
View orthologs and multiple alignments for TED4

Proteins

heme oxygenase 1
Refseq ID NP_001118392
Protein GI 186503279
UniProt ID O48782
mRNA ID NM_001124920
Length 234
RefSeq Status REVIEWED
MAYLAPISSSLSIFKNPQLSRFQFSSSSPNPLFLRPRIQILSMTMNKSPSLVVVAATTAAEKQKKRYPGESKGFVEEMRFVAMRLHTKDQAKEDAEFKNTGLERAEKLSTDLEWFKEQGYEIPEPTAPGKTYSQYLKELAEKDPQAFICHFYNIYFAHSAGGRMIGRKVAERILDNKELEFYKWDGELSQLLQNVREKLNKVAEEWTREEKNHCLEETEKSFKYSGEILRLILS
heme oxygenase 1
Refseq ID NP_180235
Protein GI 15225771
UniProt ID O48782
mRNA ID NM_128224
Length 282
RefSeq Status REVIEWED
MAYLAPISSSLSIFKNPQLSRFQFSSSSPNPLFLRPRIQILSMTMNKSPSLVVVAATTAAEKQKKRYPGESKGFVEEMRFVAMRLHTKDQAKEGEKETKSIEERPVAKWEPTVEGYLRFLVDSKLVYDTLELIIQDSNFPTYAEFKNTGLERAEKLSTDLEWFKEQGYEIPEPTAPGKTYSQYLKELAEKDPQAFICHFYNIYFAHSAGGRMIGRKVAERILDNKELEFYKWDGELSQLLQNVREKLNKVAEEWTREEKNHCLEETEKSFKYSGEILRLILS

Gene Information

Entrez Gene ID
817208
Gene Name
heme oxygenase 1
Gene Symbol
TED4
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IDA:TAIR C chloroplast
GO:0020037 IDA:TAIR F heme binding
GO:0004392 IDA:TAIR F heme oxygenase (decyclizing) activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0016117 IMP:TAIR P carotenoid biosynthetic process
GO:0071494 IMP:TAIR P cellular response to UV-C
GO:0010019 IMP:TAIR P chloroplast-nucleus signaling pathway
GO:0009813 IMP:TAIR P flavonoid biosynthetic process
GO:0006788 IEA:InterPro P heme oxidation
GO:0015979 IEA:UniProtKB-KW P photosynthesis
GO:0010024 IDA:TAIR P phytochromobilin biosynthetic process
GO:0010075 IGI:TAIR P regulation of meristem growth

KEGG Pathway Links

KEGG Pathway ID Description
ath00860 Porphyrin and chlorophyll metabolism
ko00860 Porphyrin and chlorophyll metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-7170 phytochromobilin biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR016951 Haem oxygenase (decyclizing), plant
IPR016053 Haem oxygenase-like
IPR016084 Haem oxygenase-like, multi-helical

UniProt Annotations

Entry Information

Gene Name
heme oxygenase 1
Protein Entry
HMOX1_ARATH
UniProt ID
O48782
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O48782-1; Sequence=Displayed; Name=2; IsoId=O48782-2; Sequence=VSP_041652; Note=Derived from EST data. No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=1.3 uM for hemin {ECO:0000269|PubMed:12481078, ECO:0000269|PubMed:19860740}; KM=1.9 uM for ferredoxin {ECO:0000269|PubMed:12481078, ECO:0000269|PubMed:19860740}; KM=420 uM for ascorbate {ECO:0000269|PubMed:12481078, ECO:0000269|PubMed:19860740}; pH dependence: Optimum pH is 7.2. {ECO:0000269|PubMed:12481078, ECO:0000269|PubMed:19860740};
Catalytic Activity Protoheme + 3 AH(2) + 3 O(2) = biliverdin + Fe(2+) + CO + 3 A + 3 H(2)O. {ECO:0000269|PubMed:10072395, ECO:0000269|PubMed:12481078}.
Disruption Phenotype Long hypocotyl, incomplete chloroplast and leaf development, lack of photoreversible phytochromes and lack of phytochromobilin, the phytochrome chromophore. No cotyledon expansion in response to bright-red light. Increased levels of jasmonate (JA) and constitutive expression of JA-inducible defense genes. Increased sensitivity to salt stress and no acclimation response to salinity. {ECO:0000269|PubMed:10072395, ECO:0000269|PubMed:10339624, ECO:0000269|PubMed:11135121, ECO:0000269|PubMed:12232145, ECO:0000269|PubMed:12324588, ECO:0000269|PubMed:12359912, ECO:0000269|PubMed:16428602, ECO:0000269|PubMed:17567636, ECO:0000269|PubMed:20979354, ECO:0000269|PubMed:21205037, ECO:0000269|PubMed:7690685}.
Enzyme Regulation Activated by ascorbate. {ECO:0000269|PubMed:12481078}.
Function Key enzyme in the synthesis of the chromophore of the phytochrome family of plant photoreceptors. Catalyzes the opening of the heme ring to form the open-chain tetrapyrrole biliverdin IX with the release of iron and carbon monoxide (CO). Produces specifically the biliverdin IX-alpha isomer. Can form complex with heme, is ferredoxin-dependent and its activity is increased in the presence of ascorbate. Plays a role in salt acclimation signaling. May affect the plastid-to-nucleus signaling pathway by perturbing tetrapyrrole synthesis. The plastid-to-nucleus signal plays an important role in the coordinated expression of both nuclear- and chloroplast-localized genes that encode photosynthesis-related proteins. {ECO:0000269|PubMed:10072395, ECO:0000269|PubMed:10339624, ECO:0000269|PubMed:11135121, ECO:0000269|PubMed:11172074, ECO:0000269|PubMed:12232145, ECO:0000269|PubMed:12324588, ECO:0000269|PubMed:12481078, ECO:0000269|PubMed:16428602, ECO:0000269|PubMed:19860740, ECO:0000269|PubMed:20979354, ECO:0000269|PubMed:21205037, ECO:0000269|PubMed:7690685}.
Induction By salt treatment. Down-regulated by jasmonate. {ECO:0000269|PubMed:17567636, ECO:0000269|PubMed:20979354}.
Sequence Caution Sequence=AAK52998.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Similarity Belongs to the heme oxygenase family. {ECO:0000305}.
Subcellular Location Plastid, chloroplast {ECO:0000269|PubMed:10072395, ECO:0000269|PubMed:19860740}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:10339624, ECO:0000269|PubMed:16428602, ECO:0000269|PubMed:20979354}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010457 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15225771 RefSeq NP_180235 282 heme oxygenase 1
186503279 RefSeq NP_001118392 234 heme oxygenase 1

Identical Sequences to LMP010457 proteins

Reference Database Accession Length Protein Name
GI:15225771 GenBank AAM64841.1 282 heme oxygenase 1 (HO1) [Arabidopsis thaliana]
GI:15225771 GenBank AAN86160.1 282 putative heme oxygenase HO1 [Arabidopsis thaliana]
GI:15225771 GenBank ADT60866.1 282 Sequence 2622 from patent US 7847156
GI:15225771 GenBank AEC07872.1 282 heme oxygenase 1 [Arabidopsis thaliana]
GI:186503279 GenBank AEC07873.1 234 heme oxygenase 1 [Arabidopsis thaliana]
GI:15225771 gnl TIGR 282 heme oxygenase 1 (HO1) [Arabidopsis thaliana]
GI:15225771 SwissProt O48782.2 282 RecName: Full=Heme oxygenase 1, chloroplastic; Short=AtHO1; AltName: Full=Protein GENOMES UNCOUPLED 2; AltName: Full=Protein REVERSAL OF THE DET PHENOTYPE 4; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP010457 proteins

Reference Database Accession Length Protein Name
GI:186503279 DBBJ BAA77758.1 282 plastid heme oxygenase [Arabidopsis thaliana]
GI:186503279 DBBJ BAA77759.1 282 plastid heme oxygenase [Arabidopsis thaliana]
GI:186503279 GenBank AAD22107.1 282 heme oxygenase 1 [Arabidopsis thaliana]
GI:186503279 GenBank AAD22108.1 282 heme oxygenase 1 [Arabidopsis thaliana]
GI:15225771 GenBank AAG42008.2 268 putative heme oxygenase HO1, partial [Arabidopsis thaliana]
GI:186503279 GenBank AAN86160.1 282 putative heme oxygenase HO1 [Arabidopsis thaliana]
GI:15225771 GenBank EFH55255.1 282 hypothetical protein ARALYDRAFT_481532 [Arabidopsis lyrata subsp. lyrata]
GI:186503279 GenBank ADT60866.1 282 Sequence 2622 from patent US 7847156
GI:15225771 GenBank EOA27657.1 282 hypothetical protein CARUB_v10023804mg [Capsella rubella]
GI:15225771 RefSeq XP_002878996.1 282 hypothetical protein ARALYDRAFT_481532 [Arabidopsis lyrata subsp. lyrata]
GI:15225771 RefSeq XP_006294759.1 282 hypothetical protein CARUB_v10023804mg [Capsella rubella]
GI:15225771 RefSeq XP_010510880.1 283 PREDICTED: heme oxygenase 1, chloroplastic-like [Camelina sativa]