Gene/Proteome Database (LMPD)

LMPD ID
LMP010419
Gene ID
818752
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1
Gene Symbol
GPDHC1
Synonyms
T32G6.6; T32G6_6
Alternate Names
glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1
Chromosome
2
EC Number
1.1.1.8
Summary
Encodes a protein with NAD-dependent glycerol-3-phosphate (G3P) dehydrogenase which was shown to complement an Escherichia coli strain: BB20-14, auxotrophic for glycerol/G3P due to a loss-of-function mutation in the gpsA gene.
Orthologs
View orthologs and multiple alignments for GPDHC1

Proteins

glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1
Refseq ID NP_001031525
Protein GI 79324881
UniProt ID O22216
mRNA ID NM_001036448
Length 462
RefSeq Status REVIEWED
MVGSIEAKSLQSNGSVHHIGLNLEEKLDEFRRLLGKSEKDPLRIVSVGAGAWGSVFAALLQESYGGFRDKFQIRIWRRAGRAVDRETAEHLFEVINSREDILRRLIRRCAYLKYVEARLGDRTLYADEILKDGFCLNMVDTPLCPLKVVTNLQEAVWDADIVVNGLPSTETREVFEEISKYWKERITVPIIISLSKGIETALEPVPHIITPTKMIHQATGVPIDNVLYLGGPNIAAEIYNKEYANARICGAAKWRKPLAKFLRQPHFIVWDNSDLVTHEVMGGLKNVYAIGAGMVAALTNESATSKSVYFAHCTSEMIFITHLLAEEPEKLAGPLLADTYVTLLKGRNAWYGQMLAKGEINRDMGDSISGKGMIQGVSAVGAFYQLLSQSSLSILPSEEKKPVAPVESCPILKTLYKILITREQSTQAILQALRDETLNDPRDRIEIAQSHAFYRPSLLGQP
glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1
Refseq ID NP_850352
Protein GI 30688691
UniProt ID O22216
mRNA ID NM_180021
Length 462
RefSeq Status REVIEWED
Protein sequence is identical to GI:79324881 (mRNA isoform)
glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1
Refseq ID NP_181685
Protein GI 15227377
UniProt ID O22216
mRNA ID NM_129717
Length 462
RefSeq Status REVIEWED
Protein sequence is identical to GI:79324881 (mRNA isoform)

Gene Information

Entrez Gene ID
818752
Gene Name
glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1
Gene Symbol
GPDHC1
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:TAIR C cytosol
GO:0009331 IEA:InterPro C glycerol-3-phosphate dehydrogenase complex
GO:0051287 TAS:TAIR F NAD binding
GO:0004367 IGI:TAIR F glycerol-3-phosphate dehydrogenase [NAD+] activity
GO:0005975 IEA:InterPro P carbohydrate metabolic process
GO:0046168 IEA:InterPro P glycerol-3-phosphate catabolic process
GO:0006950 IEA:UniProtKB-KW P response to stress

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6118 glycerol-3-phosphate shuttle

Domain Information

InterPro Annotations

Accession Description
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR013328 Dehydrogenase, multihelical
IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent
IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal
IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1
Protein Entry
GPDHC_ARATH
UniProt ID
O22216
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH.
Disruption Phenotype No visible phenotype under normal growth conditions, but mutant plants have increased NADH/NAD(+) ratios, decreased levels of glycerol-3-phosphate, and produce constitutive high levels of reactive oxygen species (ROS). {ECO:0000269|PubMed:16415206}.
Function Involved in cell redox homeostasis. Required for maintaining a steady state cellular NADH/NAD(+) ratio through a mitochondrial glycerol-3-phosphate redox shuttle. May function with the mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase SDP6 to shuttle reducing equivalents into the mitochondria for respiration. {ECO:0000269|PubMed:16415206}.
Induction By abscisic acid and salt and dehydration treatments. Down-regulated by hypoxia. {ECO:0000269|PubMed:16415206}.
Similarity Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. {ECO:0000305}.
Subcellular Location Cytoplasm, cytosol {ECO:0000250}.
Tissue Specificity Expressed in roots, leaves, flowers and siliques. {ECO:0000269|PubMed:16415206}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010419 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
79324881 RefSeq NP_001031525 462 glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1

Identical Sequences to LMP010419 proteins

Reference Database Accession Length Protein Name
GI:79324881 GenBank AAM14186.1 462 putative glycerol-3-phosphate dehydrogenase [Arabidopsis thaliana]
GI:79324881 GenBank AEC09996.1 462 glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1 [Arabidopsis thaliana]
GI:79324881 GenBank AEC09997.1 462 glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1 [Arabidopsis thaliana]
GI:79324881 GenBank AEC09998.1 462 glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1 [Arabidopsis thaliana]
GI:79324881 RefSeq NP_850352.1 462 glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1 [Arabidopsis thaliana]
GI:79324881 SwissProt O22216.1 462 RecName: Full=Glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1, cytosolic [Arabidopsis thaliana]

Related Sequences to LMP010419 proteins

Reference Database Accession Length Protein Name
GI:79324881 DBBJ BAH20028.1 462 AT2G41540 [Arabidopsis thaliana]
GI:79324881 GenBank EFH56196.1 462 GPDHC1 [Arabidopsis lyrata subsp. lyrata]
GI:79324881 GenBank EOA27068.1 462 hypothetical protein CARUB_v10023165mg [Capsella rubella]
GI:79324881 RefSeq XP_002879937.1 462 GPDHC1 [Arabidopsis lyrata subsp. lyrata]
GI:79324881 RefSeq XP_006294170.1 462 hypothetical protein CARUB_v10023165mg [Capsella rubella]
GI:79324881 RefSeq XP_010505937.1 462 PREDICTED: glycerol-3-phosphate dehydrogenase [NAD(+)] GPDHC1, cytosolic [Camelina sativa]