Gene/Proteome Database (LMPD)

LMPD ID
LMP010165
Gene ID
837568
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
dynamin-like protein 6
Gene Symbol
ADL6
Synonyms
DRP2A; dynamin-like protein 6; DYNAMIN-RELATED PROTEIN 2A; F14N23.17; F14N23_17
Alternate Names
dynamin-like protein 6
Chromosome
1
EC Number
3.6.5.5
Summary
involved in trafficking from the trans-Golgi Network to the central vacuole.
Orthologs
View orthologs and multiple alignments for ADL6

Proteins

dynamin-like protein 6
Refseq ID NP_172500
Protein GI 15218486
UniProt ID Q9SE83
mRNA ID NM_100903
Length 914
RefSeq Status REVIEWED
MEAIDELSQLSDSMKQAASLLADEDPDETSSSKRPATFLNVVALGNVGAGKSAVLNSLIGHPVLPTGENGATRAPIIIELSRESSLSSKAIILQIDNKSQQVSASALRHSLQDRLSKGASGKNRDEINLKLRTSTAPPLKLVDLPGLDQRIVDESMIAEYAQHNDAILLVIVPASQASEISSSRALKIAKEYDPESTRTIGIIGKIDQAAENSKALAAVQALLSNQGPPKTTDIPWVAVIGQSVSIASAQSGSGENSLETAWRAESESLKSILTGAPQSKLGRIALVDTLASQIRSRMKLRLPSVLSGLQGKSQIVQDELARLGEQLVNSAEGTRAIALELCREFEDKFLLHLAGGEGSGWKVVASFEGNFPNRIKQLPLDRHFDLNNVKRVVLEADGYQPYLISPEKGLRSLIKIVLELAKDPARLCVDEVHRVLVDIVSASANATPGLGRYPPFKREVVAIASAALDGFKNEAKKMVVALVDMERAFVPPQHFIRLVQRRMERQRREEELKGRSSKKGQDAEQSLLSRATSPQPDGPTAGGSLKSMKDKPSPQDKETPEVSGLKTAGPEGEITAGYLMKKSAKTNGWSRRWFVLNEKTGKLGYTKKQEERNFRGTITLEECTIEEIPEDEVEKSKSSKDKKANGPDSKGPGLVFKITCKVPYKTVLKAHNALVLKAESVVDKNEWINKLQKVIQARGGQVGSVSMRQSLSEGSLDKMVRKPIDPEEELRWMSQEVRGYVEAVLNSLAANVPKAVVLCQVEKAKEDMLNQLYSSISAIGNERIESLIQEDQNVKRRRERYQKQSSLLSKLTRQLSIHDNRAAAASSYSDNSGTESSPRASGGSSGDDWMNAFNSAANGPSDSLSKYGSGGHSRRYSDPAQNGDAASPGSGSNRRTTPNRLPPAPPPTGSAYRY

Gene Information

Entrez Gene ID
837568
Gene Name
dynamin-like protein 6
Gene Symbol
ADL6
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:TAIR C Golgi apparatus
GO:0016020 IDA:TAIR C membrane
GO:0005874 IEA:UniProtKB-KW C microtubule
GO:0005886 IDA:TAIR C plasma membrane
GO:0009506 IDA:TAIR C plasmodesma
GO:0005774 IDA:TAIR C vacuolar membrane
GO:0005525 IEA:UniProtKB-KW F GTP binding
GO:0003924 ISS:TAIR F GTPase activity
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0006184 ISS:GOC P GTP catabolic process
GO:0006896 IMP:TAIR P Golgi to vacuole transport

KEGG Pathway Links

KEGG Pathway ID Description
ath04144 Endocytosis
ko04144 Endocytosis

Domain Information

InterPro Annotations

Accession Description
IPR003130 Dynamin GTPase effector
IPR000375 Dynamin central domain
IPR022812 Dynamin superfamily
IPR001401 Dynamin, GTPase domain
IPR019762 Dynamin, GTPase region, conserved site
IPR020850 GTPase effector domain, GED
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
dynamin-like protein 6
Protein Entry
DRP2A_ARATH
UniProt ID
Q9SE83
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity GTP + H(2)O = GDP + phosphate.
Function Microtubule-associated force-producing protein involved in clathrin-mediated vesicle trafficking from the trans-Golgi network to the central vacuole. Able to bind and hydrolyze GTP. Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P). {ECO:0000269|PubMed:11449048, ECO:0000269|PubMed:12105222, ECO:0000269|PubMed:12207647}.
Sequence Caution Sequence=AAD32879.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Similarity Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. {ECO:0000305}.
Similarity Contains 1 GED domain. {ECO:0000255|PROSITE- ProRule:PRU00720}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 1 dynamin-type G (guanine nucleotide-binding) domain. {ECO:0000305}.
Subcellular Location Cytoplasm, cytosol. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, phragmoplast. Note=Localized in the forming cell plate during cytokinesis.
Subunit Binds PtdIns3P. Interacts with SH3P3 protein. May homooligomerize or heterooligomerize. {ECO:0000269|PubMed:12207647, ECO:0000269|PubMed:14750520}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010165 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15218486 RefSeq NP_172500 914 dynamin-like protein 6

Identical Sequences to LMP010165 proteins

Reference Database Accession Length Protein Name
GI:15218486 GenBank AEE28562.1 914 dynamin-like protein 6 [Arabidopsis thaliana]
GI:15218486 SwissProt Q9SE83.2 914 RecName: Full=Dynamin-2A; AltName: Full=Dynamin-like protein 6; AltName: Full=Dynamin-related protein 2A [Arabidopsis thaliana]

Related Sequences to LMP010165 proteins

Reference Database Accession Length Protein Name
GI:15218486 DBBJ BAF00882.1 914 putative phragmoplastin [Arabidopsis thaliana]
GI:15218486 GenBank AAF22291.1 914 dynamin-like protein 6 [Arabidopsis thaliana]
GI:15218486 GenBank EFH66058.1 914 hypothetical protein ARALYDRAFT_471140 [Arabidopsis lyrata subsp. lyrata]
GI:15218486 GenBank EOA39624.1 911 hypothetical protein CARUB_v10008252mg [Capsella rubella]
GI:15218486 RefSeq XP_002889799.1 914 hypothetical protein ARALYDRAFT_471140 [Arabidopsis lyrata subsp. lyrata]
GI:15218486 RefSeq XP_006306726.1 911 hypothetical protein CARUB_v10008252mg [Capsella rubella]