Gene/Proteome Database (LMPD)

LMPD ID
LMP010126
Gene ID
825832
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
sphingolipid delta-4 desaturase
Gene Symbol
DES-1-LIKE
Synonyms
DES-1-LIKE TRANSMEMBRANE PROTEIN; T1J1.1; T1J1_1
Alternate Names
sphingolipid delta-4 desaturase
Chromosome
4
EC Number
1.14.-.-
Summary
Encodes a sphingolipid delta4-desaturase, involved in sphingolipid biosynthesis. Specifically expressed in floral tissues. Knockout mutants were devoid of sphinga-4,8-dienine in floral tissues.
Orthologs
View orthologs and multiple alignments for DES-1-LIKE

Proteins

sphingolipid delta-4 desaturase
Refseq ID NP_192402
Protein GI 15234510
UniProt ID Q9ZPH4
mRNA ID NM_116731
Length 332
RefSeq Status REVIEWED
MGKGGREKISSNEEEREGVMATDFFWSYTDEPHASRRRQILSCYPQIRQLFGPDPWAFLKITLVVILQLSTAAILHNSGWLKILSIAYFFGSFLNHNLFLAIHELSHNLAFSTPVYNRCLGIFANLPIGVPMSVTFQKYHLEHHRFQGVDGIDMDVPTYTEAHLVTNIFAKTIWVFLQLFFYALRPIFIKPKPPGYWEFINFLIQIVLDVSVVLFFGWRSFAYLILSTFVGGGMHPMAGHFISEHYVFNPNQETYSYYGPLNLLTWSVGYHNEHHDFPRIPGNKLHLVKEIAGEYYEGLESYKSWSQVIYMYIMDTTVGPYSRMKRKLSKSD

Gene Information

Entrez Gene ID
825832
Gene Name
sphingolipid delta-4 desaturase
Gene Symbol
DES-1-LIKE
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0042284 IMP:TAIR F sphingolipid delta-4 desaturase activity
GO:0030148 IMP:TAIR P sphingolipid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01100 Metabolic pathways
ath00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6254191 Sphingolipid de novo biosynthesis
6254192 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR005804 Fatty acid desaturase, type 1
IPR011388 Sphingolipid delta4-desaturase
IPR013866 Sphingolipid delta4-desaturase, N-terminal

UniProt Annotations

Entry Information

Gene Name
sphingolipid delta-4 desaturase
Protein Entry
DES1L_ARATH
UniProt ID
Q9ZPH4
Species
Arabidopsis

Comments

Comment Type Description
Disruption Phenotype No visible phenotype under normal growth conditions. {ECO:0000269|PubMed:18978071}.
Function Sphingolipid-delta-4-desaturase required for the biosynthesis of delta-4-unsaturated sphingolipids and derivatives. May be required for the biosynthesis of glucosylceramides. {ECO:0000269|PubMed:18978071}.
Similarity Belongs to the fatty acid desaturase family. DEGS subfamily. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Specifically expressed in flowers. {ECO:0000269|PubMed:18978071}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010126 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15234510 RefSeq NP_192402 332 sphingolipid delta-4 desaturase

Identical Sequences to LMP010126 proteins

Reference Database Accession Length Protein Name
GI:15234510 DBBJ BAD95415.1 332 putative fatty acid desaturase [Arabidopsis thaliana]
GI:15234510 EMBL CAB81035.1 332 putative fatty acid desaturase [Arabidopsis thaliana]
GI:15234510 GenBank AAD17340.1 332 similar to the Drosophila DES-1 protein (GB:X94180) [Arabidopsis thaliana]
GI:15234510 GenBank AAF27915.1 332 DES-1-like transmembrane protein [Arabidopsis thaliana]
GI:15234510 GenBank AEE82444.1 332 sphingolipid delta-4 desaturase [Arabidopsis thaliana]
GI:15234510 SwissProt Q9ZPH4.1 332 RecName: Full=Sphingolipid delta(4)-desaturase DES1-like [Arabidopsis thaliana]

Related Sequences to LMP010126 proteins

Reference Database Accession Length Protein Name
GI:15234510 GenBank ESQ38105.1 335 hypothetical protein EUTSA_v10028789mg [Eutrema salsugineum]
GI:15234510 GenBank KFK31002.1 332 hypothetical protein AALP_AA6G055800 [Arabis alpina]
GI:15234510 RefSeq XP_006396652.1 335 hypothetical protein EUTSA_v10028789mg [Eutrema salsugineum]
GI:15234510 RefSeq XP_007211574.1 332 hypothetical protein PRUPE_ppa008431mg [Prunus persica]
GI:15234510 RefSeq XP_009114530.1 334 PREDICTED: sphingolipid delta(4)-desaturase DES1 [Brassica rapa]
GI:15234510 RefSeq XP_010422336.1 337 PREDICTED: sphingolipid delta(4)-desaturase DES1-like [Camelina sativa]