Gene/Proteome Database (LMPD)

LMPD ID
LMP010081
Gene ID
828019
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
cytochrome P450 86A2
Gene Symbol
CYP86A2
Synonyms
ABERRANT INDUCTION OF TYPE THREE 1; ATT1; A_IG005I10.21; A_IG005I10_21; CYP86A2; cytochrome P450; F5I10.21; F5I10_21; family 86; polypeptide 2; subfamily A
Alternate Names
cytochrome P450 86A2
Chromosome
4
EC Number
1.14.14.1
Summary
Encodes a member of the CYP86A subfamily of cytochrome p450 genes. Expressed at moderate levels in flowers, leaves, roots and stems.
Orthologs
View orthologs and multiple alignments for CYP86A2

Proteins

cytochrome P450 86A2
Refseq ID NP_191946
Protein GI 15236789
UniProt ID O23066
mRNA ID NM_116260
Length 553
RefSeq Status REVIEWED
MDVSNTMLLVAVVAAYWLWFQRISRWLKGPRVWPVLGSLPGLIEQRDRMHDWITENLRACGGTYQTCICAVPFLAKKQGLVTVTCDPKNIEHMLKTRFDNYPKGPTWQAVFHDFLGQGIFNSDGDTWLFQRKTAALEFTTRTLRQAMGRWVNRGIKLRFCPILETAQNNYEPVDLQDLILRLTFDNICGLAFGKDTRTCAPGLPENGFASAFDRATEASLQRFILPEFLWRLKKWLGLGLEVSLSRSLGEIDGYLDAVINTRKQELLSQRESGVQRHDDLLSRFMKKKDQSYSETFLRHVALNFILAGRDTSSVALSWFFWLITTHPTVEDKIVREICSVLIETRGTDVSSWTAEPLEFDEVDRLVYLKAALSETLRLYPSVPEDSKHVVNDDILPDGTFVPAGSSVTYSIYAAGRMKSTWGEDCLEFKPERWISPDDGKFVNHDQYRFVAFNAGPRICLGKDLAYLQMKTIAAAVLLRHRLTVAPGHKVEQKMSLTLFMKNGLLVNVHKRDLEVMMKSLVPKERNDVVVLNGKCNGGIGEGVAVNAAVAVAV

Gene Information

Entrez Gene ID
828019
Gene Name
cytochrome P450 86A2
Gene Symbol
CYP86A2
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0018685 IDA:TAIR F alkane 1-monooxygenase activity
GO:0070330 IEA:UniProtKB-EC F aromatase activity
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0006952 IEA:UniProtKB-KW P defense response
GO:0006631 IDA:TAIR P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath00073 Cutin, suberine and wax biosynthesis
ko00073 Cutin, suberine and wax biosynthesis
ath01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450 86A2
Protein Entry
C86A2_ARATH
UniProt ID
O23066
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity RH + reduced flavoprotein + O(2) = ROH + oxidized flavoprotein + H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Developmental Stage Expressed in the seed coat inner integument layer facing the endosperm in the stages from globular to torpedo embryo. {ECO:0000269|PubMed:18179651}.
Disruption Phenotype No visible phenotype under normal growth conditions, but mutant plants have reduced content of cutin, loose cuticle membrane ultrastructure, show increased permeability to water vapor and display enhanced disease severity to a virulent strain of the bacterial pathogen P.syringae. {ECO:0000269|PubMed:15241470}.
Function Catalyzes the omega-hydroxylation of various fatty acids (FA). Acts on saturated and unsaturated fatty acids with chain lengths from C12 to C18. Plays a major role in the biosynthesis of extracellular lipids. Involved in the biosynthesis of hydroxylated fatty acids required for cutin biosynthesis, cuticle development and repression of bacterial type III gene expression. {ECO:0000269|PubMed:15241470, ECO:0000269|PubMed:15709153, ECO:0000269|PubMed:17427946}.
Induction By abscisic acid (ABA), auxin, wounding and drought, and in etiolated and dark-adapted seedlings. {ECO:0000269|PubMed:15709153, ECO:0000269|PubMed:19704826}.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity Expressed in leaves, stems, flowers and siliques. Expressed at low levels in roots. Expressed in guard cells of cotyledons and leaves. {ECO:0000269|PubMed:15709153, ECO:0000269|PubMed:19704826}.

Identical and Related Proteins

Unique RefSeq proteins for LMP010081 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15236789 RefSeq NP_191946 553 cytochrome P450 86A2

Identical Sequences to LMP010081 proteins

Reference Database Accession Length Protein Name
GI:15236789 EMBL CBD34030.1 553 unnamed protein product [Arabidopsis thaliana]
GI:15236789 EMBL CBD09651.1 553 unnamed protein product [Arabidopsis thaliana]
GI:15236789 EMBL CBD14308.1 553 unnamed protein product [Arabidopsis thaliana]
GI:15236789 EMBL CBD10310.1 553 unnamed protein product [Arabidopsis thaliana]
GI:15236789 EMBL CBC98074.1 553 unnamed protein product [Arabidopsis thaliana]
GI:15236789 GenBank AEE81869.1 553 cytochrome P450 86A2 [Arabidopsis thaliana]

Related Sequences to LMP010081 proteins

Reference Database Accession Length Protein Name
GI:15236789 GenBank AAL75903.1 553 AT4g00360/A_IG005I10_21 [Arabidopsis thaliana]
GI:15236789 GenBank AAM91369.1 553 At4g00360/A_IG005I10_21 [Arabidopsis thaliana]
GI:15236789 GenBank EFH51286.1 554 CYP86A2 [Arabidopsis lyrata subsp. lyrata]
GI:15236789 GenBank KFK30625.1 557 hypothetical protein AALP_AA6G006200 [Arabis alpina]
GI:15236789 RefSeq XP_002875027.1 554 CYP86A2 [Arabidopsis lyrata subsp. lyrata]
GI:15236789 RefSeq XP_010426970.1 556 PREDICTED: cytochrome P450 86A2 [Camelina sativa]