Gene/Proteome Database (LMPD)

LMPD ID
LMP009809
Gene ID
818353
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
aldo-keto reductase family 4 member C8
Gene Symbol
AT2G37760
Synonyms
T8P21.6
Alternate Names
aldo-keto reductase family 4 member C8
Chromosome
2
EC Number
1.1.1.-

Proteins

aldo-keto reductase family 4 member C8
Refseq ID NP_001078019
Protein GI 145330687
UniProt ID O80944
mRNA ID NM_001084550
Length 290
RefSeq Status REVIEWED
MAAPIRFFELNTGAKLPCVGLGTYAMVATAIEQAIKIGYRHIDCASIYGNEKEIGGVLKKLIGDGFVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPASLKKESLMPTPEMLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVARVTPAVNQVECHPVWQQQGLHELCKSKGVHLSGYSPLGSQSKGEVRLKVLQNPIVTEVAEKLGKTTAQVALRWGLQTGHSVLPKSSSGARLKENLDVFDWSIPEDLFTKFSNIPQAKVLPSY
aldo-keto reductase family 4 member C8
Refseq ID NP_973627
Protein GI 42571107
UniProt ID O80944
mRNA ID NM_201898
Length 290
RefSeq Status REVIEWED
MAAPIRFFELNTGAKLPCVGLGTYAMVATAIEQAIKIGYRHIDCASIYGNEKEIGGVLKKLIGDGFVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPASLKKESLMPTPEMLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVARVTPAVNQVECHPVWQQQGLHELCKSKGVHLSGYSPLGSQSKGEVRLKVLQNPIVTEVAEKLGKTTAQVALRWGLQTGHSVLPKSSSGARLKENLDVFDWSIPEDLFTKFSNIPQAKVLPSY
aldo-keto reductase family 4 member C8
Refseq ID NP_001118465
Protein GI 186506243
UniProt ID O80944
mRNA ID NM_001124993
Length 291
RefSeq Status REVIEWED
MAAPIRFFELNTGAKLPCVGLGTYAMVATAIEQAIKIGYRHIDCASIYGNEKEIGGVLKKLIGDGFVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPASLKKESLMPTPEMLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVARVTPAVNQVECHPVWQQQGLHELCKSKGVHLSGYSPLGSQSKGEVRLKVLQNPIVTEVAEKLGKTTAQVALRWGLQTGHSVLPKSSSGARLKENLDVFDWSIPEDLFTKFSNIPQAREVLPSY
aldo-keto reductase family 4 member C8
Refseq ID NP_565871
Protein GI 18404526
UniProt ID O80944
mRNA ID NM_129332
Length 311
RefSeq Status REVIEWED
MAAPIRFFELNTGAKLPCVGLGTYAMVATAIEQAIKIGYRHIDCASIYGNEKEIGGVLKKLIGDGFVKREELFITSKLWSNDHLPEDVPKALEKTLQDLQIDYVDLYLIHWPASLKKESLMPTPEMLTKPDITSTWKAMEALYDSGKARAIGVSNFSSKKLTDLLNVARVTPAVNQVECHPVWQQQGLHELCKSKGVHLSGYSPLGSQSKGEVRLKVLQNPIVTEVAEKLGKTTAQVALRWGLQTGHSVLPKSSSGARLKENLDVFDWSIPEDLFTKFSNIPQEKFCRATEFAHETHGFYKTIEELWDGEI
aldo-keto reductase family 4 member C8
Refseq ID NP_973626
Protein GI 145362176
UniProt ID O80944
mRNA ID NM_201897
Length 311
RefSeq Status REVIEWED
Protein sequence is identical to GI:18404526 (mRNA isoform)

Gene Information

Entrez Gene ID
818353
Gene Name
aldo-keto reductase family 4 member C8
Gene Symbol
AT2G37760
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:TAIR C cytosol
GO:0070401 IDA:UniProtKB F NADP+ binding
GO:0004033 IDA:UniProtKB F aldo-keto reductase (NADP) activity
GO:0016229 IDA:UniProtKB F steroid dehydrogenase activity
GO:0055114 IDA:TAIR P oxidation-reduction process
GO:0046686 IEP:TAIR P response to cadmium ion
GO:0009409 IEP:UniProtKB P response to cold
GO:0009651 IEP:UniProtKB P response to salt stress
GO:0009636 IEA:UniProtKB-KW P response to toxic substance
GO:0009414 IEP:UniProtKB P response to water deprivation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5453 methylglyoxal degradation III

Domain Information

InterPro Annotations

Accession Description
IPR001395 Aldo/keto reductase
IPR020471 Aldo/keto reductase subgroup
IPR018170 Aldo/keto reductase, conserved site
IPR023210 NADP-dependent oxidoreductase domain

UniProt Annotations

Entry Information

Gene Name
aldo-keto reductase family 4 member C8
Protein Entry
AKRC8_ARATH
UniProt ID
O80944
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O80944-1; Sequence=Displayed; Name=2; IsoId=O80944-2; Sequence=VSP_040012, VSP_040015; Note=Derived from EST data. No experimental confirmation available.; Name=3; IsoId=O80944-3; Sequence=VSP_040013, VSP_040014; Note=Derived from EST data. No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=4.4 uM for 9,10-phenanthrenequinone {ECO:0000269|PubMed:19616008}; KM=35 uM for isatin {ECO:0000269|PubMed:19616008}; KM=1.6 mM for glyoxal {ECO:0000269|PubMed:19616008}; KM=3.3 mM for methylglyoxal {ECO:0000269|PubMed:19616008}; KM=22.4 mM for glyceraldehyde {ECO:0000269|PubMed:19616008};
Function Oxidoreductase acting on a broad range of substrates: reduces ketosteroids, aromatic aldehydes, ketones, sugars and other aliphatic aldehydes, and oxidizes hydroxysteroids. May function as detoxifiying enzyme by reducing a range of toxic aldehydes and ketones produced during stress. {ECO:0000269|PubMed:19616008}.
Induction By drought, salt and cold stresses. {ECO:0000269|PubMed:19616008}.
Similarity Belongs to the aldo/keto reductase family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009809 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
18404526 RefSeq NP_565871 311 aldo-keto reductase family 4 member C8
186506243 RefSeq NP_001118465 291 aldo-keto reductase family 4 member C8
145330687 RefSeq NP_001078019 290 aldo-keto reductase family 4 member C8
42571107 RefSeq NP_973627 290 aldo-keto reductase family 4 member C8

Identical Sequences to LMP009809 proteins

Reference Database Accession Length Protein Name
GI:18404526 GenBank ABH07514.1 311 aldo-keto reductase [Arabidopsis thaliana]
GI:18404526 GenBank AEC09443.1 311 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:18404526 GenBank AEC09444.1 311 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:145330687 GenBank AEC09445.1 290 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:42571107 GenBank AEC09445.1 290 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:42571107 GenBank AEC09446.1 290 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:145330687 GenBank AEC09446.1 290 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:186506243 GenBank AEC09447.1 291 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:18404526 GenBank AEL84870.1 311 Sequence 305 from patent US 7989676
GI:145330687 RefSeq NP_973627.1 290 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:42571107 RefSeq NP_001078019.1 290 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:18404526 RefSeq NP_973626.2 311 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:18404526 RefSeq XP_004253291.1 311 PREDICTED: aldo-keto reductase family 4 member C8 isoform X1 [Solanum lycopersicum]
GI:186506243 RefSeq XP_010314927.1 291 PREDICTED: aldo-keto reductase family 4 member C8 isoform X2 [Solanum lycopersicum]
GI:42571107 RefSeq XP_010314928.1 290 PREDICTED: aldo-keto reductase family 4 member C8 isoform X3 [Solanum lycopersicum]
GI:145330687 RefSeq XP_010314928.1 290 PREDICTED: aldo-keto reductase family 4 member C8 isoform X3 [Solanum lycopersicum]

Related Sequences to LMP009809 proteins

Reference Database Accession Length Protein Name
GI:42571107 GenBank AAM51246.1 311 putative alcohol dehydrogenase [Arabidopsis thaliana]
GI:145330687 GenBank AAM51246.1 311 putative alcohol dehydrogenase [Arabidopsis thaliana]
GI:18404526 GenBank EFH55966.1 311 aldo/keto reductase family protein [Arabidopsis lyrata subsp. lyrata]
GI:18404526 GenBank AEC09445.1 290 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:186506243 GenBank AEC09445.1 290 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:18404526 GenBank AEC09446.1 290 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:186506243 GenBank AEC09446.1 290 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:145330687 GenBank AEC09447.1 291 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:42571107 GenBank AEC09447.1 291 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:145330687 gnl TIGR 311 putative alcohol dehydrogenase [Arabidopsis thaliana]
GI:42571107 gnl TIGR 311 putative alcohol dehydrogenase [Arabidopsis thaliana]
GI:186506243 gnl TIGR 311 putative alcohol dehydrogenase [Arabidopsis thaliana]
GI:186506243 RefSeq NP_973627.1 290 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:186506243 RefSeq NP_001078019.1 290 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:18404526 RefSeq NP_001078019.1 290 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:42571107 RefSeq NP_001118465.1 291 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:145330687 RefSeq NP_001118465.1 291 aldo-keto reductase family 4 member C8 [Arabidopsis thaliana]
GI:18404526 RefSeq XP_002879707.1 311 aldo/keto reductase family protein [Arabidopsis lyrata subsp. lyrata]
GI:42571107 RefSeq XP_004253291.1 311 PREDICTED: aldo-keto reductase family 4 member C8 isoform X1 [Solanum lycopersicum]
GI:145330687 RefSeq XP_004253291.1 311 PREDICTED: aldo-keto reductase family 4 member C8 isoform X1 [Solanum lycopersicum]
GI:42571107 RefSeq XP_010314927.1 291 PREDICTED: aldo-keto reductase family 4 member C8 isoform X2 [Solanum lycopersicum]
GI:145330687 RefSeq XP_010314927.1 291 PREDICTED: aldo-keto reductase family 4 member C8 isoform X2 [Solanum lycopersicum]
GI:18404526 RefSeq XP_010314928.1 290 PREDICTED: aldo-keto reductase family 4 member C8 isoform X3 [Solanum lycopersicum]
GI:186506243 RefSeq XP_010314928.1 290 PREDICTED: aldo-keto reductase family 4 member C8 isoform X3 [Solanum lycopersicum]