Gene/Proteome Database (LMPD)

LMPD ID
LMP009751
Gene ID
833655
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
acetyl-CoA synthetase
Gene Symbol
ACS
Synonyms
acetyl-CoA synthetase; ACS
Alternate Names
acetyl-CoA synthetase
Chromosome
5
EC Number
6.2.1.1

Proteins

acetyl-CoA synthetase
Refseq ID NP_001031974
Protein GI 145323645
UniProt ID B9DGD6
mRNA ID NM_001036897
Length 743
RefSeq Status REVIEWED
MKIGSPSSPILSVVSSSGSLDPKISGSLGSRILPATQRSSPSENLLLHRKMSSNSLRHVESMSQLPSGAGKISQLNAVVLGESLASEENDLVFPSKEFSGQALVSSPQQYMEMHKRSMDDPAAFWSDIASEFYWKQKWGDQVFSENLDVRKGPISIEWFKGGITNICYNCLDKNVEAGLGDKTAIHWEGNELGVDASLTYSELLQRVCQLANYLKDNGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSADSLAQRIVDCKPNVILTCNAVKRGPKTINLKAIVDAALDQSSKDGVSVGICLTYDNSLATTRENTKWQNGRDVWWQDVISQYPTSCEVEWVDAEDPLFLLYTSGSTGKPKGVLHTTGGYMIYTATTFKYAFDYKSTDVYWCTADCGWITGHSYVTYGPMLNGATVVVFEGAPNYPDPGRCWDIVDKYKVSIFYTAPTLVRSLMRDDDKFVTRHSRKSLRVLGSVGEPINPSAWRWFFNVVGDSRCPISDTWWQTETGGFMITPLPGAWPQKPGSATFPFFGVQPVIVDEKGNEIEGECSGYLCVKGSWPGAFRTLFGDHERYETTYFKPFAGYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVLHPQCAEAAVVGIEHEVKGQGIYAFVTLLEGVPYSEELRKSLVLMVRNQIGAFAAPDRIHWAPGLPKTRSGKIMRRILRKIASRQLEELGDTSTLADPSVVDQLIALADV
acetyl-CoA synthetase
Refseq ID NP_198504
Protein GI 15239431
UniProt ID B9DGD6
mRNA ID NM_123046
Length 693
RefSeq Status REVIEWED
MSSNSLRHVESMSQLPSGAGKISQLNAVVLGESLASEENDLVFPSKEFSGQALVSSPQQYMEMHKRSMDDPAAFWSDIASEFYWKQKWGDQVFSENLDVRKGPISIEWFKGGITNICYNCLDKNVEAGLGDKTAIHWEGNELGVDASLTYSELLQRVCQLANYLKDNGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSADSLAQRIVDCKPNVILTCNAVKRGPKTINLKAIVDAALDQSSKDGVSVGICLTYDNSLATTRENTKWQNGRDVWWQDVISQYPTSCEVEWVDAEDPLFLLYTSGSTGKPKGVLHTTGGYMIYTATTFKYAFDYKSTDVYWCTADCGWITGHSYVTYGPMLNGATVVVFEGAPNYPDPGRCWDIVDKYKVSIFYTAPTLVRSLMRDDDKFVTRHSRKSLRVLGSVGEPINPSAWRWFFNVVGDSRCPISDTWWQTETGGFMITPLPGAWPQKPGSATFPFFGVQPVIVDEKGNEIEGECSGYLCVKGSWPGAFRTLFGDHERYETTYFKPFAGYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVLHPQCAEAAVVGIEHEVKGQGIYAFVTLLEGVPYSEELRKSLVLMVRNQIGAFAAPDRIHWAPGLPKTRSGKIMRRILRKIASRQLEELGDTSTLADPSVVDQLIALADV

Gene Information

Entrez Gene ID
833655
Gene Name
acetyl-CoA synthetase
Gene Symbol
ACS
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0009507 IDA:TAIR C chloroplast
GO:0009570 IDA:TAIR C chloroplast stroma
GO:0005829 IDA:TAIR C cytosol
GO:0009514 IEA:UniProtKB-KW C glyoxysome
GO:0016208 IEA:InterPro F AMP binding
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0003987 IMP:TAIR F acetate-CoA ligase activity
GO:0006083 IMP:TAIR P acetate metabolic process
GO:0019427 IEA:InterPro P acetyl-CoA biosynthetic process from acetate
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ath01200 Carbon metabolism
ath00010 Glycolysis / Gluconeogenesis
ath00620 Pyruvate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6253693 Ethanol oxidation

Domain Information

InterPro Annotations

Accession Description
IPR025110 AMP-binding enzyme C-terminal domain
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase
IPR011904 Acetate-CoA ligase

UniProt Annotations

Entry Information

Gene Name
acetyl-CoA synthetase
Protein Entry
ACS_ARATH
UniProt ID
B9DGD6
Species
Arabidopsis

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=B9DGD6-1; Sequence=Displayed; Name=2; IsoId=B9DGD6-2; Sequence=VSP_042326; Note=No experimental confirmation available.;
Catalytic Activity ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA. {ECO:0000269|PubMed:10859180}.
Developmental Stage In the forming silique, expressed in the funiculus and ovule from 1 to 3 day after flowering (DAF). At 3 DAF, expressed in the globular embryo, but expression decreases at 5 DAF and almost disappears at 7 DAF in the embryo. By 1 d after imbibition, expressed in the tip of seed radicle and then in the root tip up to 4 d after imbibition. {ECO:0000269|PubMed:10859180}.
Function Catalyzes the production of acetyl-CoA, an activated form of acetate that can be used for lipid synthesis or for energy generation. May play a limited role in the biosynthesis of lipids. {ECO:0000269|PubMed:10859180, ECO:0000269|PubMed:12051672}.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location Plastid, chloroplast. Glyoxysome.
Tissue Specificity Expressed in leaves, flower buds and young flowers. {ECO:0000269|PubMed:10859180}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009751 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
145323645 RefSeq NP_001031974 743 acetyl-CoA synthetase
15239431 RefSeq NP_198504 693 acetyl-CoA synthetase

Identical Sequences to LMP009751 proteins

Reference Database Accession Length Protein Name
GI:15239431 DBBJ BAA98066.1 693 acetyl-CoA synthetase [Arabidopsis thaliana]
GI:145323645 DBBJ BAH19803.1 743 AT5G36880 [Arabidopsis thaliana]
GI:15239431 EMBL CBN62150.1 693 unnamed protein product [Arabidopsis thaliana]
GI:15239431 EMBL CBN59933.1 693 unnamed protein product [Arabidopsis thaliana]
GI:15239431 GenBank AAK76554.1 693 putative acetyl-CoA synthetase [Arabidopsis thaliana]
GI:15239431 GenBank AAN86204.1 693 putative acetyl-CoA synthetase [Arabidopsis thaliana]
GI:15239431 gnl TAIR 693 acetyl-CoA synthetase [Arabidopsis thaliana]
GI:145323645 gnl TAIR 743 acetyl-CoA synthetase [Arabidopsis thaliana]
GI:145323645 SwissProt B9DGD6.1 743 RecName: Full=Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal; AltName: Full=Acetate--CoA ligase; AltName: Full=Acetyl-CoA synthetase; Flags: Precursor [Arabidopsis thaliana]

Related Sequences to LMP009751 proteins

Reference Database Accession Length Protein Name
GI:145323645 DBBJ BAA98066.1 693 acetyl-CoA synthetase [Arabidopsis thaliana]
GI:15239431 DBBJ BAH19803.1 743 AT5G36880 [Arabidopsis thaliana]
GI:15239431 GenBank ABA65418.1 693 Sequence 2 from patent US 6942994
GI:15239431 GenBank ACR90688.1 693 Sequence 2 from patent US 7524678
GI:145323645 GenBank EFH46747.1 743 AMP binding protein [Arabidopsis lyrata subsp. lyrata]
GI:145323645 gnl TAIR 693 acetyl-CoA synthetase [Arabidopsis thaliana]
GI:15239431 gnl TAIR 743 acetyl-CoA synthetase [Arabidopsis thaliana]
GI:15239431 RefSeq NP_001031974.2 743 acetyl-CoA synthetase [Arabidopsis thaliana]
GI:145323645 RefSeq XP_002870488.1 743 AMP binding protein [Arabidopsis lyrata subsp. lyrata]
GI:145323645 RefSeq XP_010435515.1 743 PREDICTED: acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal isoform X1 [Camelina sativa]
GI:145323645 RefSeq XP_010450452.1 743 PREDICTED: acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal-like isoform X1 [Camelina sativa]
GI:15239431 SwissProt B9DGD6.1 743 RecName: Full=Acetyl-coenzyme A synthetase, chloroplastic/glyoxysomal; AltName: Full=Acetate--CoA ligase; AltName: Full=Acetyl-CoA synthetase; Flags: Precursor [Arabidopsis thaliana]