Gene/Proteome Database (LMPD)

LMPD ID
LMP009705
Gene ID
839131
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
3-ketoacyl-CoA synthase 5
Gene Symbol
KCS5
Synonyms
3-ketoacyl-CoA synthase 5; CER60; ECERIFERUM 60; F2J7.9; F2J7_9; KCS5
Alternate Names
3-ketoacyl-CoA synthase 5
Chromosome
1
EC Number
2.3.1.199
Summary
Encodes KCS5, a member of the 3-ketoacyl-CoA synthase family involved in the biosynthesis of VLCFA (very long chain fatty acids).
Orthologs
View orthologs and multiple alignments for KCS5

Proteins

3-ketoacyl-CoA synthase 5
Refseq ID NP_173916
Protein GI 15222592
UniProt ID Q9C6L5
mRNA ID NM_102356
Length 492
RefSeq Status REVIEWED
MSDFSSSVKLKYVKLGYQYLINNFLTLLLIPVIATVAIELLRMGPEEILSVLNSLHFELLHILCSSFLIIFVSTVYFMSKPRTVYLVDYSCYKPPVTCRVPFSSFMEHSRLILKDNPKSVEFQMRILERSGLGEETCLPPAIHYIPPTPTMESARNEAQMVIFTAMEDLFKNTGLKPKDIDILIVNCSLFSPTPSLSAMIINKYKLRSNIKSYNLSGMGCSASLISVDVARDLLQVHPNSNAIIISTEIITPNYYKGNERAMLLPNCLFRMGGAAILLSNRRSDRWRAKYKLCHLVRTHRGADDKSYNCVMEQEDKNGNVGINLSKDLMTIAGEALKANITTIGPLVLPASEQLLFLSSLIGRKIFNPKWKPYIPDFKQAFEHFCIHAGGRAVIDELQKNLQLSGEHVEASRMTLHRFGNTSSSSLWYELSYIEAQGRMKRNDRVWQIAFGSGFKCNSAVWKCNRTIKTPTDGAWSDCIERYPVFIPEVVKL

Gene Information

Entrez Gene ID
839131
Gene Name
3-ketoacyl-CoA synthase 5
Gene Symbol
KCS5
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:TAIR C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:TAIR C membrane
GO:0009922 IDA:TAIR F fatty acid elongase activity
GO:0006633 IEA:UniProtKB-UniPathway P fatty acid biosynthetic process
GO:0048868 IMP:TAIR P pollen tube development
GO:0009409 IEP:TAIR P response to cold
GO:0009416 IEP:TAIR P response to light stimulus

KEGG Pathway Links

KEGG Pathway ID Description
ath01110 Biosynthesis of secondary metabolites
ath_M00415 Fatty acid biosynthesis, elongation, endoplasmic reticulum
ath00062 Fatty acid elongation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5080 very long chain fatty acid biosynthesis I

Domain Information

InterPro Annotations

Accession Description
IPR013747 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal
IPR013601 FAE1/Type III polyketide synthase-like protein
IPR016039 Thiolase-like
IPR016038 Thiolase-like, subgroup
IPR012392 Very-long-chain 3-ketoacyl-CoA synthase

UniProt Annotations

Entry Information

Gene Name
3-ketoacyl-CoA synthase 5
Protein Entry
KCS5_ARATH
UniProt ID
Q9C6L5
Species
Arabidopsis

Comments

Comment Type Description
Catalytic Activity A very-long-chain acyl-CoA + malonyl-CoA = CoA + a very-long-chain 3-oxoacyl-CoA + CO(2).
Enzyme Regulation Inhibited by K3 herbicides such as alachlor, allidochlor, anilofos, cafenstrole and flufenacet. {ECO:0000269|PubMed:15277688}.
Function Mediates mostly the synthesis of VLCFAs from 26 to 30 carbons in length (e.g. C20:1, C26, C28, C30). {ECO:0000269|PubMed:15277688}.
Induction Repressed by herbicides such as flufenacet and benfuresate. {ECO:0000269|PubMed:12916765}.
Pathway Lipid metabolism; fatty acid biosynthesis.
Ptm Ubiquitinated. {ECO:0000269|PubMed:19292762}.
Similarity Belongs to the chalcone/stilbene synthases family. {ECO:0000305}.
Similarity Contains 1 FAE (fatty acid elongase) domain. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000269|PubMed:15277688}; Multi-pass membrane protein {ECO:0000269|PubMed:15277688}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009705 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15222592 RefSeq NP_173916 492 3-ketoacyl-CoA synthase 5

Identical Sequences to LMP009705 proteins

Reference Database Accession Length Protein Name
GI:15222592 GenBank AAG50800.1 492 fatty acid condensing enzyme CUT1, putative [Arabidopsis thaliana]
GI:15222592 GenBank ACX18481.1 492 Sequence 46329 from patent US 7569389
GI:15222592 GenBank AEE30626.1 492 3-ketoacyl-CoA synthase 5 [Arabidopsis thaliana]
GI:15222592 SwissProt Q9C6L5.1 492 RecName: Full=3-ketoacyl-CoA synthase 5; Short=KCS-5; AltName: Full=Very long-chain fatty acid condensing enzyme 5; Short=VLCFA condensing enzyme 5 [Arabidopsis thaliana]

Related Sequences to LMP009705 proteins

Reference Database Accession Length Protein Name
GI:15222592 EMBL CAW45956.1 492 unnamed protein product [Arabidopsis thaliana]
GI:15222592 EMBL CAW71216.1 492 unnamed protein product [Arabidopsis thaliana]
GI:15222592 EMBL CBC11458.1 492 unnamed protein product [Arabidopsis thaliana]
GI:15222592 EMBL CBC60938.1 492 unnamed protein product [Arabidopsis thaliana]
GI:15222592 GenBank AAM67234.1 492 fatty acid condensing enzyme CUT1, putative [Arabidopsis thaliana]
GI:15222592 GenBank AAO42223.1 492 putative fatty acid condensing enzyme CUT1 [Arabidopsis thaliana]