Gene/Proteome Database (LMPD)

LMPD ID
LMP009643
Gene ID
826593
Species
Arabidopsis thaliana (Arabidopsis)
Gene Name
hydroxysteroid dehydrogenase 5
Gene Symbol
HSD5
Synonyms
AtHSD5; HSD5; hydroxysteroid dehydrogenase 5; T5L19.150; T5L19_150
Alternate Names
hydroxysteroid dehydrogenase 5
Chromosome
4
EC Number
1.1.1.-
Summary
Encodes a putative hydroxysteroid dehydrogenase (HSD). Genes that encode HSD include: At5g50600 and At5g50700 (HSD1), At3g47350(HSD2), At3g47360(HSD3), At5g50590 and At5g50690(HSD4), At5g50770(HSD6) (Plant Cell Physiology 50:1463). Two copies of HSD1 and HSD4 exist due to a gene duplication event. In Plant Physiology 145:87, At5g50690 is HSD7, At4g10020 is HSD5.
Orthologs
View orthologs and multiple alignments for HSD5

Proteins

hydroxysteroid dehydrogenase 5
Refseq ID NP_192740
Protein GI 15234888
UniProt ID Q9T0G0
mRNA ID NM_117070
Length 389
RefSeq Status REVIEWED
MVDLLNSVMNLVAPPATMVVMAFAWPLLSFISFSERAYNSYFATENMEDKVVVITGASSAIGEQIAYEYAKRGANLVLVARREQRLRVVSNKAKQIGANHVIIIAADVIKEDDCRRFITQAVNYYGRVDHLVNTASLGHTFYFEEVSDTTVFPHLLDINFWGNVYPTYVALPYLHQTNGRIVVNASVENWLPLPRMSLYSAAKAALVNFYETLRFELNGDVGITIATHGWIGSEMSGGKFMLEEGAEMQWKEEREVPANGGPLEEFAKMIVAGACRGDAYVKFPNWYDVFLLYRVFTPNVLRWTFKLLLSTEGTRRSSLVGVGSGMPVDESSSQMKLMLEGGPPRVPASPPRYTASPPHYTASPPRYPASPPRYPASPPRFSQFNIQEL

Gene Information

Entrez Gene ID
826593
Gene Name
hydroxysteroid dehydrogenase 5
Gene Symbol
HSD5
Species
Arabidopsis thaliana

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016491 IEA:UniProtKB-KW F oxidoreductase activity
GO:0006694 IEA:UniProtKB-KW P steroid biosynthetic process

REACTOME Pathway Links

REACTOME Pathway ID Description
6254052 Glucocorticoid biosynthesis
6253653 Metabolism
6253725 Metabolism of lipids and lipoproteins
6254047 Metabolism of steroid hormones and vitamin D

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid dehydrogenase 5
Protein Entry
HSD5_ARATH
UniProt ID
Q9T0G0
Species
Arabidopsis

Comments

Comment Type Description
Sequence Caution Sequence=BT004103; Type=Frameshift; Positions=117; Evidence={ECO:0000305};
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009643 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
15234888 RefSeq NP_192740 389 hydroxysteroid dehydrogenase 5

Identical Sequences to LMP009643 proteins

Reference Database Accession Length Protein Name
GI:15234888 EMBL CAB39626.1 389 putative oxidoreductase [Arabidopsis thaliana]
GI:15234888 EMBL CAB78125.1 389 putative oxidoreductase [Arabidopsis thaliana]
GI:15234888 GenBank AED75723.1 389 Sequence 17 from patent US 7910718
GI:15234888 GenBank AEE82830.1 389 hydroxysteroid dehydrogenase 5 [Arabidopsis thaliana]
GI:15234888 GenBank AFL64812.1 389 Sequence 76 from patent US 8188339
GI:15234888 SwissProt Q9T0G0.1 389 RecName: Full=11-beta-hydroxysteroid dehydrogenase-like 5; AltName: Full=17-beta-hydroxysteroid dehydrogenase-like 5; AltName: Full=Hydroxysteroid dehydrogenase 5; Short=AtHSD5 [Arabidopsis thaliana]

Related Sequences to LMP009643 proteins

Reference Database Accession Length Protein Name
GI:15234888 GenBank EFH48742.1 382 short-chain dehydrogenase/reductase family protein [Arabidopsis lyrata subsp. lyrata]
GI:15234888 GenBank EOA22380.1 389 hypothetical protein CARUB_v10003016mg [Capsella rubella]
GI:15234888 RefSeq XP_002872483.1 382 short-chain dehydrogenase/reductase family protein [Arabidopsis lyrata subsp. lyrata]
GI:15234888 RefSeq XP_006289482.1 389 hypothetical protein CARUB_v10003016mg [Capsella rubella]
GI:15234888 RefSeq XP_010437678.1 382 PREDICTED: 11-beta-hydroxysteroid dehydrogenase-like 5 [Camelina sativa]
GI:15234888 RefSeq XP_010455398.1 382 PREDICTED: 11-beta-hydroxysteroid dehydrogenase-like 5 [Camelina sativa]