Gene/Proteome Database (LMPD)

LMPD ID
LMP009191
Gene ID
41605
Species
Drosophila melanogaster (Drosophila)
Gene Name
rosy
Gene Symbol
ry
Synonyms
CG7642; Dmel\CG7642; xdh; Xdh; XDH; Xdh/ry; XOR
Alternate Names
CG7642-PA; rosy; ry-PA; xanthine DH; xanthine dehydrogenase
Chromosome
3R
Map Location
87D9-87D9
EC Number
1.17.1.4

Proteins

rosy
Refseq ID NP_524337
Protein GI 17737937
UniProt ID P10351
mRNA ID NM_079613
Length 1335
RefSeq Status REVIEWED
MSNSVLVFFVNGKKVTEVSPDPECTLLTFLREKLRLCGTKLGCAEGGCGACTVMVSRLDRRANKIRHLAVNACLTPVCSMHGCAVTTVEGIGSTKTRLHPVQERLAKAHGSQCGFCTPGIVMSMYALLRNAEQPSMRDLEVAFQGNLCRCTGYRPILEGYKTFTKEFACGMGEKCCKVSGKGCGTDAETDDKLFERSEFQPLDPSQEPIFPPELQLSDAFDSQSLIFSSDRVTWYRPTNLEELLQLKAKHPAAKLVVGNTEVGVEVKFKHFLYPHLINPTQVKELLEIKENQDGIYFGAAVSLMEIDALLRQRIEQLPESETRLFQCTVDMLHYFAGKQIRNVACLGGNIMTGSPISDMNPVLSAAGAQLEVASFVDGKLQKRSVHMGTGFFTGYRRNVIEAHEVLLGIHFRKTTPDQYIVAFKQARRRDDDIAIVNAAINVRFEEKSNIVAEISMAFGGMAPTTVLAPRTSQLMVGQEWSHQLVERVAESLCTELPLAASAPGGMIAYRRALVVSLFFKAYLAISLKLSKSGITSSDALPSEERSGAETFHTPVLKSAQLFERVCSDQPICDPIGRPKVHAAALKQATGEAIYTDDIPRMDGEVYLAFVLSTKPRAKITKLDASEALALDGVHQFFCYKDLTEHENEVGPVFHDEHVFAAGEVHCYGQIVGAIAADNKALAQRAARLVKVEYEELSPVIVTIEQAIEHKSYFPDYPRFVTKGNVEEALAQADHTFEGTCRMGGQEHFYLETHAALAVPRDSDELELFCSTQHPSEVQKLVAHVTALPAHRVVCRAKRLGGGFGGKESRGISVALPVALAAYRMGRPVRCMLDRDEDMLITGTRHPFLFKYKVGFTKEGLITACDIECYNNAGWSMDLSFSVLERAMFHFENCYRIPNVRVGGWVCKTNLPSNTAFRGFGGPQGMYAGEHIIRDVARIVGRDVVDVMRLNFYKTGDYTHYHQQLEHFPIERCLEDCLKQSRYDEKRQEIARFNRENRWRKRGMAVVPTKYGIAFGVMHLNQAGSLINIYGDGSVLLSHGGVEIGQGLNTKMIQCAARALGIPSELIHISETATDKVPNTSPTAASVGSDLNGMAVLDACEKLNKRLAPIKEALPGGTWKEWINKAYFDRVSLSATGFYAMPGIGYHPETNPNARTYSYYTNGVGVTVVEIDCLTGDHQVLSTDIVMDIGSSLNPAIDIGQIEGAFMQGYGLFTLEELMYSPQGMLYSRGPGMYKLPGFADIPGEFNVSLLTGAPNPRAVYSSKAVGEPPLFIGSSAFFAIKEAIAAAREDQGLSGDFPLEAPSTSARIRIACQDKFTELLEIPEPGSFTPWNIVP

Gene Information

Entrez Gene ID
41605
Gene Name
rosy
Gene Symbol
ry
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005875 IDA:FlyBase C microtubule associated complex
GO:0005777 IEA:UniProtKB-KW C peroxisome
GO:0051537 ISS:UniProtKB F 2 iron, 2 sulfur cluster binding
GO:0008762 IEA:InterPro F UDP-N-acetylmuramate dehydrogenase activity
GO:0009055 IEA:InterPro F electron carrier activity
GO:0050660 ISS:UniProtKB F flavin adenine dinucleotide binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0043546 ISS:UniProtKB F molybdopterin cofactor binding
GO:0004854 ISS:UniProtKB F xanthine dehydrogenase activity
GO:0004855 IEA:InterPro F xanthine oxidase activity
GO:0006525 IMP:FlyBase P arginine metabolic process
GO:0048072 TAS:FlyBase P compound eye pigmentation
GO:0008340 IMP:FlyBase P determination of adult lifespan
GO:0006650 IMP:FlyBase P glycerophospholipid metabolic process
GO:0006144 IMP:FlyBase P purine nucleobase metabolic process
GO:0006206 IMP:FlyBase P pyrimidine nucleobase metabolic process
GO:0006568 IMP:FlyBase P tryptophan metabolic process
GO:0009115 ISS:UniProtKB P xanthine catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
dme00983 Drug metabolism - other enzymes
dme04146 Peroxisome
dme00230 Purine metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
6225978 Purine catabolism

Domain Information

InterPro Annotations

Accession Description
IPR006058 2Fe-2S ferredoxin, iron-sulphur binding site
IPR001041 2Fe-2S ferredoxin-type domain
IPR016208 Aldehyde oxidase/xanthine dehydrogenase
IPR000674 Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead
IPR008274 Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding
IPR012675 Beta-grasp domain
IPR005107 CO dehydrogenase flavoprotein, C-terminal
IPR016169 CO dehydrogenase flavoprotein-like, FAD-binding, subdomain 2
IPR016166 FAD-binding, type 2
IPR016167 FAD-binding, type 2, subdomain 1
IPR002346 Molybdopterin dehydrogenase, FAD-binding
IPR022407 Oxidoreductase, molybdopterin binding site
IPR014307 Xanthine dehydrogenase, small subunit
IPR002888 [2Fe-2S]-binding

UniProt Annotations

Entry Information

Gene Name
rosy
Protein Entry
XDH_DROME
UniProt ID
P10351
Species
Drosophila

Comments

Comment Type Description
Catalytic Activity Hypoxanthine + NAD(+) + H(2)O = xanthine + NADH.
Catalytic Activity Xanthine + NAD(+) + H(2)O = urate + NADH.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
Cofactor Name=Mo-molybdopterin; Xref=ChEBI:CHEBI:71302; Evidence={ECO:0000250}; Note=Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit. {ECO:0000250};
Cofactor Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence={ECO:0000250}; Note=Binds 2 [2Fe-2S] clusters. {ECO:0000250};
Function Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid (By similarity). {ECO:0000250}.
Sequence Caution Sequence=AAM11042.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the xanthine dehydrogenase family. {ECO:0000305}.
Similarity Contains 1 2Fe-2S ferredoxin-type domain. {ECO:0000255|PROSITE-ProRule:PRU00465}.
Similarity Contains 1 FAD-binding PCMH-type domain. {ECO:0000255|PROSITE-ProRule:PRU00718}.
Subcellular Location Peroxisome {ECO:0000250}.
Subunit Homodimer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009191 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17737937 RefSeq NP_524337 1335 rosy

Identical Sequences to LMP009191 proteins

Reference Database Accession Length Protein Name
GI:17737937 EMBL CAY36067.1 1335 unnamed protein product [Drosophila melanogaster]
GI:17737937 EMBL CAY38312.1 1335 unnamed protein product [Drosophila melanogaster]
GI:17737937 GenBank AAQ62072.1 1335 ROSY [Transformation vector pICon]
GI:17737937 GenBank AAT94522.1 1335 GH05219p [Drosophila melanogaster]
GI:17737937 gnl FlyBase 1335 rosy [Drosophila melanogaster]
GI:17737937 SwissProt P10351.2 1335 RecName: Full=Xanthine dehydrogenase; Short=XD; AltName: Full=Protein rosy locus [Drosophila melanogaster]

Related Sequences to LMP009191 proteins

Reference Database Accession Length Protein Name
GI:17737937 EMBL CBC45818.1 1335 unnamed protein product [Drosophila melanogaster]
GI:17737937 EMBL CBC04890.1 1335 unnamed protein product [Drosophila melanogaster]
GI:17737937 EMBL CBC12987.1 1335 unnamed protein product [Drosophila melanogaster]
GI:17737937 EMBL CBC02637.1 1335 unnamed protein product [Drosophila melanogaster]
GI:17737937 EMBL CBC06850.1 1335 unnamed protein product [Drosophila melanogaster]
GI:17737937 EMBL CBC89074.1 1335 unnamed protein product [Drosophila melanogaster]