Gene/Proteome Database (LMPD)

LMPD ID
LMP009187
Gene ID
34961
Species
Drosophila melanogaster (Drosophila)
Gene Name
heixuedian
Gene Symbol
heix
Synonyms
124/1; BG:DS02740.7; CG5876; Dmel\CG5876; ipa-6d; l(2)35Fc; l(2)k12401
Alternate Names
CG5876-PA; heix-PA; heixuedian; lethal(2)35Fc
Chromosome
2L
Map Location
35F1-35F1
EC Number
2.5.1.-

Proteins

heixuedian
Refseq ID NP_523581
Protein GI 17737429
UniProt ID Q9V3R8
mRNA ID NM_078857
Length 359
RefSeq Status REVIEWED
MATSSQLLPNGNLSRNGKTKTEDGEEVEAVVGARAAGADAGVALTGRLTGHPSTSGTFMKLKTYLLALRPWSLSASLVPTLLGSALAYRSQWAEEFSLATFFLTAFTVVTVHCAGNVVNTYFDFIKGIDKQKADDRTLVDHILTKDEVVSLGAILYMAGCGGFVLLAVLSPAKMEHLALIYFGGLSSSFLYTGGIGFKYIALGDLVILILFGPISVLFAFMSQTGHLDWTTMGYAIPLALNTEAILHSNNTRDADNDRRAGIVTLAILIGRTASHVLYAMLLFAPYSLFFIFGLKYSLWFLLPLVTLPQAFQIEKRFRNEQTMHLVPRQTAKLNFFFGILYVVACCCAHQLPTFGLRRN

Gene Information

Entrez Gene ID
34961
Gene Name
heixuedian
Gene Symbol
heix
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 ISS:UniProtKB C membrane
GO:0005739 IDA:FlyBase C mitochondrion
GO:0004659 IEA:UniProtKB-KW F prenyltransferase activity
GO:0009234 IMP:FlyBase P menaquinone biosynthetic process

Domain Information

InterPro Annotations

Accession Description
IPR004657 1,4-dihydroxy-2-naphthoate octaprenyltransferase
IPR026046 UbiA prenyltransferase domain containing protein 1
IPR000537 UbiA prenyltransferase family

UniProt Annotations

Entry Information

Gene Name
heixuedian
Protein Entry
UBIA1_DROME
UniProt ID
Q9V3R8
Species
Drosophila

Comments

Comment Type Description
Function Prenyltransferase that mediates the formation of menaquinone-4 (MK-4), a vitamin K2 isoform, thereby acting as a mitochondrial electron carrier. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. MK-4 acts as a membrane electron carrier downstream of a electron transport chain complex, improving mitochondrial oxygen consumption. {ECO:0000269|PubMed:22582012}.
Pathway Quinol/quinone metabolism; menaquinone biosynthesis.
Similarity Belongs to the UbiA prenyltransferase family. {ECO:0000305}.
Subcellular Location Mitochondrion membrane {ECO:0000269|PubMed:22582012}; Multi-pass membrane protein {ECO:0000269|PubMed:22582012}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009187 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17737429 RefSeq NP_523581 359 heixuedian

Identical Sequences to LMP009187 proteins

Reference Database Accession Length Protein Name
GI:17737429 GenBank AAL28641.1 359 LD08295p [Drosophila melanogaster]
GI:17737429 GenBank AAL34085.1 359 HEIX [Drosophila melanogaster]
GI:17737429 GenBank ACL84185.1 359 heix-PA, partial [synthetic construct]
GI:17737429 GenBank ACL89272.1 359 heix-PA [synthetic construct]
GI:17737429 GenBank AGC99292.1 359 Sequence 31 from patent US 8334369
GI:17737429 SwissProt Q9V3R8.1 359 RecName: Full=UbiA prenyltransferase domain-containing protein 1 homolog; AltName: Full=Protein heixuedian [Drosophila melanogaster]

Related Sequences to LMP009187 proteins

Reference Database Accession Length Protein Name
GI:17737429 GenBank EDV58093.1 358 GG24176 [Drosophila erecta]
GI:17737429 GenBank EDW54568.1 359 GM17914 [Drosophila sechellia]
GI:17737429 GenBank EDX05203.1 359 GD21924 [Drosophila simulans]
GI:17737429 RefSeq XP_001969034.1 358 GG24176 [Drosophila erecta]
GI:17737429 RefSeq XP_002038150.1 359 GM17914 [Drosophila sechellia]
GI:17737429 RefSeq XP_002079618.1 359 GD21924 [Drosophila simulans]