Gene/Proteome Database (LMPD)

LMPD ID
LMP009142
Gene ID
43656
Species
Drosophila melanogaster (Drosophila)
Gene Name
tailless
Gene Symbol
tll
Synonyms
CG1378; dm-tll; Dmel\CG1378; NR2E2; Tll; TLL
Alternate Names
CG1378-PA; tailles; tailless; tll-PA
Chromosome
3R
Map Location
100A6-100A6

Proteins

tailless
Refseq ID NP_524596
Protein GI 17864126
UniProt ID P18102
mRNA ID NM_079857
Length 452
RefSeq Status REVIEWED
MQSSEGSPDMMDQKYNSVRLSPAASSRILYHVPCKVCRDHSSGKHYGIYACDGCAGFFKRSIRRSRQYVCKSQKQGLCVVDKTHRNQCRACRLRKCFEVGMNKDAVQHERGPRNSTLRRHMAMYKDAMMGAGEMPQIPAEILMNTAALTGFPGVPMPMPGLPQRAGHHPAHMAAFQPPPSAAAVLDLSVPRVPHHPVHQGHHGFFSPTAAYMNALATRALPPTPPLMAAEHIKETAAEHLFKNVNWIKSVRAFTELPMPDQLLLLEESWKEFFILAMAQYLMPMNFAQLLFVYESENANREIMGMVTREVHAFQEVLNQLCHLNIDSTEYECLRAISLFRKSPPSASSTEDLANSSILTGSGSPNSSASAESRGLLESGKVAAMHNDARSALHNYIQRTHPSQPMRFQTLLGVVQLMHKVSSFTIEELFFRKTIGDITIVRLISDMYSQRKI

Gene Information

Entrez Gene ID
43656
Gene Name
tailless
Gene Symbol
tll
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0003677 IDA:FlyBase F DNA binding
GO:0003705 IDA:FlyBase F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0004879 NAS:FlyBase F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0043565 IEA:InterPro F sequence-specific DNA binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0001746 TAS:FlyBase P Bolwig's organ morphogenesis
GO:0009948 TAS:FlyBase P anterior/posterior axis specification
GO:0045165 IMP:FlyBase P cell fate commitment
GO:0001708 TAS:FlyBase P cell fate specification
GO:0007369 NAS:FlyBase P gastrulation
GO:0030522 NAS:GOC P intracellular receptor signaling pathway
GO:0016319 IMP:FlyBase P mushroom body development
GO:0055057 IMP:FlyBase P neuroblast division
GO:0001748 IMP:FlyBase P optic lobe placode development
GO:0045944 IMP:FlyBase P positive regulation of transcription from RNA polymerase II promoter
GO:0051726 IMP:FlyBase P regulation of cell cycle
GO:0035271 IMP:FlyBase P ring gland development
GO:0007362 IGI:FlyBase P terminal region determination
GO:0008293 IGI:FlyBase P torso signaling pathway
GO:0006366 IDA:GOC P transcription from RNA polymerase II promoter
GO:0006351 NAS:FlyBase P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
dme04013 MAPK signaling pathway - fly

REACTOME Pathway Links

REACTOME Pathway ID Description
6225926 Gene Expression
6226331 Generic Transcription Pathway
6226616 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
tailless
Protein Entry
TLL_DROME
UniProt ID
P18102
Species
Drosophila

Comments

Comment Type Description
Developmental Stage During stage 10 found in the anterior part of the visual system that later gives rise to the anterior lip of the optic lobe. At stage 12 also found in the posterior lip of the optic lobe. In third larval instar expressed in the optic lobe of the larval brain and in the eye antennal disk, both in antennal and eye portion. {ECO:0000269|PubMed:2364433}.
Function Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half- site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. This receptor binds to the consensus sequence [AG][AG]AAGTCAA. Plays a key role in the establishment of non-metameric domains at the anterior and posterior poles of the embryo. It may also play a role in the nervous system. The maternal terminal pathway activates the tll gene in the termini; TLL activity then represses segmentation and activates terminal-specific genes in these domains. Involved in the regulation of early eye development. In the embryonic visual system anlage drives cells to optic lobe as opposed to Bolwig's organ fate. {ECO:0000269|PubMed:10357938, ECO:0000269|PubMed:2364433}.
Similarity Belongs to the nuclear hormone receptor family. NR2 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Subunit Monomer. {ECO:0000250}.
Tissue Specificity Brain and peripheral nervous system. {ECO:0000269|PubMed:2364433}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009142 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17864126 RefSeq NP_524596 452 tailless

Identical Sequences to LMP009142 proteins

Reference Database Accession Length Protein Name
GI:17864126 GenBank AAA28936.1 452 tailless (tll) protein [Drosophila melanogaster]
GI:17864126 GenBank AAB71371.1 452 tailless protein [Drosophila melanogaster]
GI:17864126 GenBank AAY51589.1 452 IP01133p [Drosophila melanogaster]
GI:17864126 GenBank ACL84203.1 452 tll-PA, partial [synthetic construct]
GI:17864126 GenBank ACL89194.1 452 tll-PA [synthetic construct]
GI:17864126 gnl FlyBase 452 tailless [Drosophila melanogaster]

Related Sequences to LMP009142 proteins

Reference Database Accession Length Protein Name
GI:17864126 GenBank EDV30466.1 456 GF22927 [Drosophila ananassae]
GI:17864126 GenBank EDW99156.1 452 GE10907 [Drosophila yakuba]
GI:17864126 GenBank EDX15060.1 452 GD21550 [Drosophila simulans]
GI:17864126 RefSeq XP_001964670.1 456 GF22927 [Drosophila ananassae]
GI:17864126 RefSeq XP_002099444.1 452 GE10907 [Drosophila yakuba]
GI:17864126 RefSeq XP_002105557.1 452 GD21550 [Drosophila simulans]