Gene/Proteome Database (LMPD)

LMPD ID
LMP009114
Gene ID
37166
Species
Drosophila melanogaster (Drosophila)
Gene Name
CG15093 gene product from transcript CG15093-RB
Gene Symbol
CG15093
Synonyms
CG 15093; CT34968; Dmel\CG15093
Alternate Names
3-hydroxyisobutyrate dehydrogenase; CG15093; CG15093-PA; CG15093-PB; CG15093-PE
Chromosome
2R
Map Location
55F2-55F2
EC Number
1.1.1.31

Proteins

CG15093, isoform A
Refseq ID NP_725824
Protein GI 24655230
UniProt ID Q9V8M5
mRNA ID NM_166306
Length 324
RefSeq Status REVIEWED
Protein sequence is identical to GI:320544135 (mRNA isoform)
CG15093, isoform B
Refseq ID NP_611373
Protein GI 19922568
UniProt ID Q9V8M5
mRNA ID NM_137529
Length 324
RefSeq Status REVIEWED
Protein sequence is identical to GI:320544135 (mRNA isoform)
CG15093, isoform E
Refseq ID NP_001188972
Protein GI 320544135
UniProt ID Q9V8M5
mRNA ID NM_001202043
Length 324
RefSeq Status REVIEWED
MSLRVMSPAMLNAWSQTLVRAMSTQGGAKNIGFVGLGNMGANMASNLIKAGHKLHVFDISKPACDGLAAKGATVYAKTSELAKNSDFVITMLPNNAIVDASYDEMTADGVNKDTIFIDSSTISPDLVKSLQKKISAKGARFIDAPVSGGVPGAEQATLTFMVGGTEAEYNAVKAVLECMGKKITHCGVYGMGQAAKLCNNMMLAISMIGVSEAMNLAVRQGLDANVFAEIINSSTGRCWASEIYNPVPGVCPSAPANRDYAGGFSSALITKDLGLASGVANASNSPIPLGSLAHKVYQSLCDKGLGNKDFSVVYDLMKKEKFSV

Gene Information

Entrez Gene ID
37166
Gene Name
CG15093 gene product from transcript CG15093-RB
Gene Symbol
CG15093
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005811 IDA:FlyBase C lipid particle
GO:0005739 IDA:FlyBase C mitochondrion
GO:0008442 IEA:UniProtKB-EC F 3-hydroxyisobutyrate dehydrogenase activity
GO:0051287 IEA:InterPro F NAD binding
GO:0004616 IEA:InterPro F phosphogluconate dehydrogenase (decarboxylating) activity
GO:0006098 IEA:InterPro P pentose-phosphate shunt
GO:0006574 IEA:UniProtKB-UniPathway P valine catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
dme01200 Carbon metabolism
dme00030 Pentose phosphate pathway
dme_M00004 Pentose phosphate pathway (Pentose phosphate cycle)
dme_M00006 Pentose phosphate pathway, oxidative phase, glucose 6P => ribulose 5P

Domain Information

InterPro Annotations

Accession Description
IPR011548 3-hydroxyisobutyrate dehydrogenase
IPR002204 3-hydroxyisobutyrate dehydrogenase-related, conserved site
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
IPR013328 Dehydrogenase, multihelical
IPR015815 Hydroxy monocarboxylic acid anion dehydrogenase, HIBADH-type
IPR016040 NAD(P)-binding domain
IPR029154 NADP-dependent 3-hydroxyisobutyrate dehydrogenase, NAD-binding domain

UniProt Annotations

Entry Information

Gene Name
CG15093 gene product from transcript CG15093-RB
Protein Entry
3HIDH_DROME
UniProt ID
Q9V8M5
Species
Drosophila

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=A; Synonyms=B; IsoId=Q9V8M5-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=C; IsoId=Q9V8M5-2; Sequence=VSP_001281, VSP_001282; Note=No experimental confirmation available.;
Catalytic Activity 3-hydroxy-2-methylpropanoate + NAD(+) = 2- methyl-3-oxopropanoate + NADH.
Pathway Amino-acid degradation; L-valine degradation.
Sequence Caution Sequence=AAL39202.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the 3-hydroxyisobutyrate dehydrogenase family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009114 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
320544135 RefSeq NP_001188972 324 CG15093, isoform E

Identical Sequences to LMP009114 proteins

Reference Database Accession Length Protein Name
GI:320544135 GenBank ACL84542.1 324 CG15093-PA, partial [synthetic construct]
GI:320544135 GenBank ACL89477.1 324 CG15093-PA [synthetic construct]
GI:320544135 gnl FlyBase 324 CG15093, isoform B [Drosophila melanogaster]
GI:320544135 gnl FlyBase 324 CG15093, isoform E [Drosophila melanogaster]
GI:320544135 RefSeq NP_611373.1 324 CG15093, isoform B [Drosophila melanogaster]
GI:320544135 RefSeq NP_725824.1 324 CG15093, isoform A [Drosophila melanogaster]

Related Sequences to LMP009114 proteins

Reference Database Accession Length Protein Name
GI:320544135 GenBank AAL39202.2 345 GH06781p, partial [Drosophila melanogaster]
GI:320544135 GenBank EDV55136.1 324 GG20945 [Drosophila erecta]
GI:320544135 GenBank EDW48519.1 324 GM19876 [Drosophila sechellia]
GI:320544135 GenBank EDW91575.1 324 GE13884 [Drosophila yakuba]
GI:320544135 RefSeq XP_002034506.1 324 GM19876 [Drosophila sechellia]
GI:320544135 RefSeq XP_002091863.1 324 GE13884 [Drosophila yakuba]