Gene/Proteome Database (LMPD)

LMPD ID
LMP009113
Gene ID
43689
Species
Drosophila melanogaster (Drosophila)
Gene Name
CG1544 gene product from transcript CG1544-RA
Gene Symbol
CG1544
Synonyms
Dmel\CG1544
Alternate Names
CG1544; CG1544-PA
Chromosome
3R
Map Location
100B5-100B5
EC Number
1.2.4.2

Proteins

CG1544
Refseq ID NP_651849
Protein GI 24651589
UniProt ID Q9VA02
mRNA ID NM_143592
Length 919
RefSeq Status REVIEWED
MLRYLALSEAGIAKLPRPQSRCYHSEKGVWGYKPIAQREFQVAEDVRASRNSQANVYRFVEAFRQHGHKLAAVNPISIRTSQQELQELSPAFYGLQTQEPVRTDGLLSGPQVAHNVAQLEQLLKDIYCGRSTSAEFSYVEDIEEREWLARNFETLDQQQLGKSERCEIAELLIKSQAWDNFMALKFPTVKRYGGEGAESMLAFFWQLLRDSVQANIEHVVLAMPHRGRTPLQAALLNMRPAKVFRKLSGASEFSEDIEAMSDVISHFHVSEQLKILGKKLSFSMVRNPSHLEAANPVAMGKTRSKQQARGEGAFGDGSQPFGEHVLNVILHGDAAFAGQGINQECLNMAYVPHFEVGGSLHLIVNNQVGFTTPGDRGRSTAYTSDLAKSIQAPVFHVNGDDPEALARVTSLAFRYQREFRKDIFIDLNCFRRWGHNELDDPTFTNPLVYKIVHQRESVPDLYAQQLAKEQVLSESKAKEMRDEYMKYLGEELALAPAYQPPPSYFEKQWTNFQLAPSKELTYWDTGLDYSLLHYIGQQSVTFPEDFNIHPHLLKTHVNARLKKLENGVKIDWSTAEALAIGSLMYQGHNVRISGEDVGRGTFSHRHAMLVDQQTNEMFIPLNSMEGGNGGKLELAHSILSEEAVLGFEYGMAIDNPNNLIIWEAQFGDFANGAQIIIDTFIVSGETKWMESNALVMLLPHGYDGAASEHSSCRIERFLQLCDSKETSADGDSVNVHIVNPTTPAQYYHVLRRQLARNFRKPLVVVAPKTLLRLPAATSTHEDFQPGTLFHNVLGDTIAKPEQVRKVILCSGKHYYTLAEEREKRQAYDTAILRLESLCPFPIQELQAQLAQYGNVQSFVWSQEEHRNMGAWTFVRPRFENLIGQQLHYCGRCEAPTPATGIGKVHKREVDEIVAAPFEL

Gene Information

Entrez Gene ID
43689
Gene Name
CG1544 gene product from transcript CG1544-RA
Gene Symbol
CG1544
Species
Drosophila melanogaster

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031966 ISS:UniProtKB C mitochondrial membrane
GO:0004591 ISS:UniProtKB F oxoglutarate dehydrogenase (succinyl-transferring) activity
GO:0030976 IEA:InterPro F thiamine pyrophosphate binding
GO:0006091 ISS:UniProtKB P generation of precursor metabolites and energy
GO:0006096 IEA:UniProtKB-KW P glycolytic process
GO:0006099 IEA:InterPro P tricarboxylic acid cycle

Domain Information

InterPro Annotations

Accession Description
IPR011603 2-oxoglutarate dehydrogenase E1 component
IPR001017 Dehydrogenase, E1 component
IPR029061 Thiamin diphosphate-binding fold
IPR005475 Transketolase-like, pyrimidine-binding domain

UniProt Annotations

Entry Information

Gene Name
CG1544 gene product from transcript CG1544-RA
Protein Entry
DHTK1_DROME
UniProt ID
Q9VA02
Species
Drosophila

Comments

Comment Type Description
Catalytic Activity 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO(2).
Cofactor Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000250};
Function The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). {ECO:0000250}.
Sequence Caution Sequence=AAM48330.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the alpha-ketoglutarate dehydrogenase family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP009113 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
24651589 RefSeq NP_651849 919 CG1544

Identical Sequences to LMP009113 proteins

Reference Database Accession Length Protein Name
GI:24651589 GenBank AGV77165.1 919 FI21467p1 [Drosophila melanogaster]
GI:24651589 gnl FlyBase 919 CG1544 [Drosophila melanogaster]
GI:24651589 SwissProt Q9VA02.2 919 RecName: Full=Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial; Flags: Precursor [Drosophila melanogaster]

Related Sequences to LMP009113 proteins

Reference Database Accession Length Protein Name
GI:24651589 GenBank AAN71328.1 919 RE22749p [Drosophila melanogaster]
GI:24651589 GenBank EDW53605.1 919 GM12925 [Drosophila sechellia]
GI:24651589 GenBank EDW99191.1 919 GE10922 [Drosophila yakuba]
GI:24651589 RefSeq XP_002037446.1 919 GM12925 [Drosophila sechellia]
GI:24651589 RefSeq XP_002099479.1 919 GE10922 [Drosophila yakuba]
GI:24651589 RefSeq XP_002105594.1 906 GD21563 [Drosophila simulans]